The goal of the proposed Institutional National Research Service Award Training Program is to provide basic and clinical neuroscientists with the skills and experiences necessary to launch an interdisciplinary research career that can contribute to understanding the neurobiology of schizophrenia and related disorders. Because neuropsychiatric disorders affect complex behavior, their study requires multidisciplinary, integrative efforts. Not only do we need to bridge across disciplines, but also the entire endeavor has to incorporate a developmental perspective. The faculty of this T32 exemplify extensive and productive collaborations spanning across the University of Pennsylvania (Penn) and the Children's Hospital of Philadelphia (CHOP). This competing renewal application capitalizes on the depth of resources, facilities and faculty dedicated to research and training in translational neuroscience. The program forges cross-fertilization of clinical neuroscientists, with expertise in assessment and treatment of complex disorders, and basic neuroscientists, with new methodologies to probe neural mechanisms pertinent to schizophrenia. The training program dovetails with the academic agenda of the Schizophrenia Research Center, where faculty interact by working collaboratively in research teams in ways that can serve as role models for trainees. We hope that our efforts will continue to help advance the careers of high quality clinical and basic neuroscientists who can move the field ahead collaboratively. Through active participation in research, combined with didactic course work, trainees learn to conduct research bridging clinical with basic neurosciences relevant to understanding the neurobiology of schizophrenia and other neuropsychiatric disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH019112-23
Application #
8474838
Study Section
Special Emphasis Panel (ZMH1-ERB-C (01))
Program Officer
Chavez, Mark
Project Start
1993-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
23
Fiscal Year
2013
Total Cost
$257,478
Indirect Cost
$22,522
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Moore, T M; Martin, I K; Gur, O M et al. (2016) Characterizing social environment's association with neurocognition using census and crime data linked to the Philadelphia Neurodevelopmental Cohort. Psychol Med 46:599-610
Yi, James J; Weinberger, Ronnie; Moore, Tyler M et al. (2016) Performance on a computerized neurocognitive battery in 22q11.2 deletion syndrome: A comparison between US and Israeli cohorts. Brain Cogn 106:33-41
Sharma, Anup; Satterthwaite, Theodore D; Vandekar, Lillie et al. (2016) Divergent relationship of depression severity to social reward responses among patients with bipolar versus unipolar depression. Psychiatry Res 254:18-25
Satterthwaite, Theodore D; Connolly, John J; Ruparel, Kosha et al. (2016) The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth. Neuroimage 124:1115-9
Moore, Tyler M; Reise, Steven P; Roalf, David R et al. (2016) Development of an itemwise efficiency scoring method: Concurrent, convergent, discriminant, and neuroimaging-based predictive validity assessed in a large community sample. Psychol Assess 28:1529-1542
Schmitt, J Eric; Yi, James; Calkins, Monica E et al. (2016) Disrupted anatomic networks in the 22q11.2 deletion syndrome. Neuroimage Clin 12:420-8
Satterthwaite, Theodore D; Kable, Joseph W; Vandekar, Lillie et al. (2015) Common and Dissociable Dysfunction of the Reward System in Bipolar and Unipolar Depression. Neuropsychopharmacology 40:2258-68
Moore, Tyler M; Scott, J Cobb; Reise, Steven P et al. (2015) Development of an abbreviated form of the Penn Line Orientation Test using large samples and computerized adaptive test simulation. Psychol Assess 27:955-64
Wolf, Daniel H; Satterthwaite, Theodore D; Calkins, Monica E et al. (2015) Functional neuroimaging abnormalities in youth with psychosis spectrum symptoms. JAMA Psychiatry 72:456-65
Tatard-Leitman, Valerie M; Jutzeler, Catherine R; Suh, Jimmy et al. (2015) Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability. Biol Psychiatry 77:556-68

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