For the past 15 years the UCLA Neuropsychology of HIV Training Program (T32 19535) has been dedicated to postdoctoral training in research on the neuropsychological sequelae of HIV infection. Funded research areas open to fellow involvement include study of neurocognitive and neuropsychiatric effects of HIV, the functional effects (e.g. medication adherence, driving ability) of neurocognitive impairment, study of the natural history of HIV infection (MACS study), correlative study of brain-behavior abnormalities (NNTC), medication trials, substance abuse, functional neuroimaging of HIV disease, study of genotypic contributions to neurological compromise, aging and AIDS, and HIV-Hepatitis C co-infection. A multidisciplinary faculty has been assembled with expertise in neuropsychology, clinical psychology, neurology, psychiatry, minority mental health and health disparities, infectious disease, public health, nursing, sociology, epidemiology, primary prevention, neuroimaging, behavioral genetics, substance abuse, and biostatistics. Fellows work with primary as well as secondary mentors on projects of their interest. This application requests funding to support three postdoctoral fellows for a period of at least two years each. Fellows will devote at least 75% to research related responsibilities. They will also receive extensive didactics, including devoting all day every Thursday to formal coursework. They will also gain clinical experience through the provision of neuropsychological evaluation of patients with HIV disease and other neurological disorders. Training in grantsmanship is also emphasized. Relevance to Public Health: The next generation of neuropsychologists studying HIV infection must be trained to deal with emerging challenges such as medical comorbidities (e.g., Hepatitis C co-infection, substance abuse, psychiatric illness), and age-related co-morbidities secondary to the """"""""graying"""""""" of the epidemic. Advances in functional neuroimaging need to be incorporated into training programs as does increased recognition of the contribution of genetic polymorphisms and correlative study exploring the relationship between post-mortem neuropathologic findings and their ante-mortem neuropsychological manifestations. Research and training targeting the functional ramifications of HIV associated neurocognitive decline in areas such as medication adherence, driving safety, financial wherewithal, and occupational fitness merit increased attention as well. Renewal of this training grant will allow us to continue this body of work, adapt to new emerging challenges attendant to the changing nature of the HIV pandemic, and continue to train the next generation of neuropsychologists who are committed to research and treatment of HIV disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH019535-20
Application #
8090263
Study Section
Special Emphasis Panel (ZMH1-ERB-Q (03))
Program Officer
Stoff, David M
Project Start
1991-04-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
20
Fiscal Year
2011
Total Cost
$161,230
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Thames, April D; Kuhn, Taylor P; Williamson, Timothy J et al. (2017) Marijuana effects on changes in brain structure and cognitive function among HIV+ and HIV- adults. Drug Alcohol Depend 170:120-127
Thames, April D; Kuhn, Taylor P; Mahmood, Zanjbeel et al. (2017) Effects of social adversity and HIV on subcortical shape and neurocognitive function. Brain Imaging Behav :
Jones, Jacob D; Kuhn, Taylor P; Szymkowicz, Sarah M (2017) Reverters from PD-MCI to cognitively intact are at risk for future cognitive impairment: Analysis of the PPMI cohort. Parkinsonism Relat Disord :
Kuhn, Taylor; Schonfeld, Daniel; Sayegh, Philip et al. (2017) The effects of HIV and aging on subcortical shape alterations: A 3D morphometric study. Hum Brain Mapp 38:1025-1037
Szymkowicz, Sarah M; Dotson, Vonetta M; Jones, Jacob D et al. (2017) Symptom Dimensions of Depression and Apathy and Their Relationship With Cognition in Parkinson's Disease. J Int Neuropsychol Soc :1-14
Kuhn, Taylor; Sayegh, Philip; Jones, Jacob D et al. (2017) Improvements in brain and behavior following eradication of hepatitis C. J Neurovirol 23:593-602
Sayegh, Philip; Thaler, Nicholas S; Arentoft, Alyssa et al. (2016) Medication Adherence in HIV-Positive African Americans: The Roles of Age, Health Beliefs, and Sensation Seeking. Cogent Psychol 3:
Arentoft, Alyssa; Van Dyk, Kathleen; Thames, April D et al. (2016) HIV-transmission-related risk behavior in HIV+ African American men: Exploring biological, psychological, cognitive, and social factors. J HIV AIDS Soc Serv 15:299-318
Arentoft, Alyssa; Van Dyk, Kathleen; Thames, April D et al. (2016) Comparing the unmatched count technique and direct self-report for sensitive health-risk behaviors in HIV+ adults. AIDS Care 28:370-5
Hines, Lindsay J; Miller, Eric N; Hinkin, Charles H et al. (2016) Cortical brain atrophy and intra-individual variability in neuropsychological test performance in HIV disease. Brain Imaging Behav 10:640-51

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