Now in its 20th year of continuous support, the UCLA Neuropsychology of HIV Research Training Program has been at the forefront of research and training focused on the neuropsychological sequelae of HIV infection. This Competing Continuation application requests renewed support to continue and extend the scope of our training program so as to support the next generation of behavioral neuroscientists as they acquire the knowledge and skills necessary for conducting independent research in neuroAIDS. Funded research areas open to fellow involvement include study of neurocognitive and neuropsychiatric effects of HIV, the functional effects (e.g. medication adherence, driving ability of neurocognitive impairment, study of the natural history of HIV infection (MACS study), correlative study of brain-behavior abnormalities (NNTC), medication trials (ACTG), health disparities associated with ethnic minority status, substance abuse, functional/structural neuroimaging of HIV disease, study of genetic contributions to neurological compromise, aging and AIDS, and HIV-Hepatitis C co-infection. A multidisciplinary faculty has been assembled with expertise in neuropsychology, clinical psychology, neurology, psychiatry, minority mental health and health disparities, infectious disease, neuroimaging, public health, epidemiology, behavioral genetics, substance abuse, and biostatistics. Fellows work with primary as well as secondary mentors on projects of their interest. To date the training grant has funded 39 fellows, 38% who are of ethnic minority background. Virtually all graduates are employed in academic settings where they continue to engage in research. During the most recent funding period our fellows have been highly productive, publishing papers, presenting at scientific conferences, and pursuing extramural grant support (54% having obtained a grant as Principal Investigator). This application requests funding to support three postdoctoral fellows for a period of two years each. Fellows will devote at least 75% effort to research related responsibilities. Other components of the fellowship include extensive didactics (including devoting all day every Thursday to formal coursework) and clinical experience through the provision of neuropsychological evaluation for patients with HIV disease and other neurological disorders. Training in grantsmanship is also emphasized.

Public Health Relevance

The purpose of this grant is to train psychologists for careers conducting research on the effects of HIV on the brain and behavior. Now in its 20th year, the UCLA Neuropsychology of HIV Research Training Program has been a leader in research and education in neuroAIDS. Renewal of this training grant will allow us to continue this body of work, adapt to new emerging challenges attendant to the changing nature of the HIV pandemic, and continue to train the next generation of neuropsychologists who are committed to research and treatment of HIV disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH019535-22
Application #
8467745
Study Section
Special Emphasis Panel (ZMH1-ERB-L (02))
Program Officer
Stoff, David M
Project Start
1991-04-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
22
Fiscal Year
2013
Total Cost
$166,724
Indirect Cost
$11,931
Name
University of California Los Angeles
Department
Psychiatry
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Panos, Stella E; Del Re, A C; Thames, April D et al. (2014) The impact of neurobehavioral features on medication adherence in HIV: evidence from longitudinal models. AIDS Care 26:79-86
Arentoft, Alyssa; Thames, April D; Panos, Stella et al. (2013) A deconstruction of gambling task performance among HIV+ individuals: the differential contributions of problem solving and risk taking. J Clin Exp Neuropsychol 35:1036-47
Thames, April D; Hinkin, Charles H; Byrd, Desiree A et al. (2013) Effects of stereotype threat, perceived discrimination, and examiner race on neuropsychological performance: simple as black and white? J Int Neuropsychol Soc 19:583-93
Patel, Sapna M; Thames, April D; Arbid, Natalie et al. (2013) The aggregate effects of multiple comorbid risk factors on cognition among HIV-infected individuals. J Clin Exp Neuropsychol 35:421-34
Foley, J M; Gooding, A L; Thames, A D et al. (2013) Visuospatial and Attentional Abilities Predict Driving Simulator Performance Among Older HIV-infected Adults. Am J Alzheimers Dis Other Demen 28:185-94
Thames, April D; Arentoft, Alyssa; Rivera-Mindt, Monica et al. (2013) Functional disability in medication management and driving among individuals with HIV: a 1-year follow-up study. J Clin Exp Neuropsychol 35:49-58
Foley, Jessica M; Ettenhofer, Mark L; Kim, Michelle S et al. (2012) Cognitive reserve as a protective factor in older HIV-positive patients at risk for cognitive decline. Appl Neuropsychol 19:16-25
Thames, April D; Foley, Jessica M; Wright, Matthew J et al. (2012) Basal ganglia structures differentially contribute to verbal fluency: evidence from Human Immunodeficiency Virus (HIV)-infected adults. Neuropsychologia 50:390-5
Wright, Matthew J; Woo, Ellen; Foley, Jessica et al. (2011) Antiretroviral adherence and the nature of HIV-associated verbal memory impairment. J Neuropsychiatry Clin Neurosci 23:324-31
Becker, Brian W; Thames, April D; Woo, Ellen et al. (2011) Longitudinal change in cognitive function and medication adherence in HIV-infected adults. AIDS Behav 15:1888-94

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