Translational research represents a major initiative for advancing knowledge of all forms of psychopathology. This work includes translating the neural mechanisms that underlie normal and abnormal behavior in animals into clinical studies of the causes and treatment of mental disorders. However, segregation of doctoral training in Neuroscience and Clinical Psychology, with separate course requirements, lab experiences, and exposure to outside speakers, impedes new scientists'preparation to undertake translational approaches in their own research. The broad, long-term objectives of the proposed Integrated Clinical Neuroscience (ICN) Training Program are to train the next generation of researchers to become leaders in translational research who will make key contributions across several areas of psychopathology characterized by dysregulated ("disinhibited") behaviors including eating disorders, suicidality, psychopathy, and externalizing spectrum disorders. These problems are associated with significant psychological and medical morbidity, elevated mortality, and high economic burden, underscoring the need for translational approaches. The ICN Training Program will provide integrated instruction and supervision to 4 predoctoral trainees earning Ph.D.s in Clinical Psychology and Neuroscience at Florida State University through several components: 1) cross-area courses, 2) cross-area lab rotations to conduct collaborative, cross-area dissertation research, 3) a Special Speaker Series in which national scholars conducting translational work will present their research to trainees, and trainees will present their ongoing research to invited speakers, ICN training faculty, the Department, and community, 4) presentation of research at conferences and in published papers, as well as 5) instruction in grant writing and additional (cross-area) instruction in the responsible conduct of research. Predoctoral trainees will apply for the ICN Training Program by describing research they plan to conduct in collaboration with their primary advisor and cross-area mentor, classes they will complete, and how the ICN Training Program will contribute to their career development as translational scientists. ICN training faculty come from the Clinical and Neuroscience programs based on cross-area connections in research addressing dysregulated behaviors. Trainees will be appointed at the beginning of their third or fourth year to ensure selection of the most promising trainees who have completed basic program requirements and have established research in their primary advisor's lab that they can extend through work in a cross-area lab rotation. The duration of support will be 2 years. This timing and duration optimize benefit of training grant support for completion of dissertation research. Training facult have strong track records of NIH funding and in training students for productive research careers. The proposed training grant will build upon this success by ensuring that new Ph.D. students are ideally positioned to initiate cutting-edge translational research as they develop independent programs of research to address mental disorders characterized by dysregulated behaviors.

Public Health Relevance

Mental problems characterized by dysregulated behaviors such as eating disorders, suicidality, psychopathy, and related disorders contribute to emotional and physical suffering and are associated with high healthcare costs and increased risk of death to the self (eating disorders and suicidality) and others (psychopathy and related disorders). The proposed training program will train the next generation of researchers to pursue translational research to address these disorders and reduce disorder-related suffering, economic burden, and mortality.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-ERB-I (01))
Program Officer
Wynne, Debra K
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Florida State University
Schools of Arts and Sciences
United States
Zip Code
Dossat, Amanda M; Bodell, Lindsay P; Williams, Diana L et al. (2015) Preliminary examination of glucagon-like peptide-1 levels in women with purging disorder and bulimia nervosa. Int J Eat Disord 48:199-205
Holland, Lauren A; Brown, Tiffany A; Keel, Pamela K (2014) Defining Features of Unhealthy Exercise Associated with Disordered Eating and Eating Disorder Diagnoses. Psychol Sport Exerc 15:
Steiner, Heinz; Warren, Brandon L; Van Waes, Vincent et al. (2014) Life-long consequences of juvenile exposure to psychotropic drugs on brain and behavior. Prog Brain Res 211:13-30
Dodd, Dorian; Smith, April; Bodell, Lindsay (2014) Restraint feeds stress: The relationship between eating disorder symptoms, stress generation, and the interpersonal theory of suicide. Eat Behav 15:567-73
Bodell, Lindsay P; Keel, Pamela K; Brumm, Michael C et al. (2014) Longitudinal examination of decision-making performance in anorexia nervosa: before and after weight restoration. J Psychiatr Res 56:150-7
Davis, Heather A; Holland, Lauren A; Keel, Pamela K (2014) A preliminary examination of a nonpurging compensatory eating disorder. Int J Eat Disord 47:239-43
Warren, Brandon L; Sial, Omar K; Alcantara, Lyonna F et al. (2014) Altered gene expression and spine density in nucleus accumbens of adolescent and adult male mice exposed to emotional and physical stress. Dev Neurosci 36:250-60
Gottfried, Emily; Bodell, Lindsay; Carbonell, Joyce et al. (2014) The clinical utility of the MMPI-2-RF Suicidal/Death Ideation Scale. Psychol Assess 26:1205-11
Alcantara, Lyonna F; Warren, Brandon L; Parise, Eric M et al. (2014) Effects of psychotropic drugs on second messenger signaling and preference for nicotine in juvenile male mice. Psychopharmacology (Berl) 231:1479-92
IƱiguez, Sergio D; Alcantara, Lyonna F; Warren, Brandon L et al. (2014) Fluoxetine exposure during adolescence alters responses to aversive stimuli in adulthood. J Neurosci 34:1007-21

Showing the most recent 10 out of 12 publications