The present application seeks continued funding for a training program at Washington University Medical School that has been jointly administered by the Departments of Neurology and Neurological Surgery for the past 29 years. The theme of the research carried out by the trainees and faculty of this grant is translational research in nervous system injury and degeneration. The primary applicant pool for the four slots requested are MD or MD/PhD residents in adult neurology, pediatric neurology, and neurosurgery at this institution. A limited number of Ph.D. candidates carrying out research consistent with the theme in the laboratories of the faculty members will also be considered, as will residents from other neuroscience-related clinical departments or residents from other institutions that seek training with our faculty. The faculty of 45 is composed of well-funded members of several clinical and basic science departments, most of whom have extensive experience in training young scientists and physician scientists. It is expected that trainees supported by this grant will carr out laboratory-based and/or clinically-based translational research for a minimum of two years as this is the minimum period necessary to develop the scientifically-trained neurological or neurosurgical clinician scientists needed to advance our understanding of the pathogenesis and treatment of these neurological disorders. In addition to the mentored research projects, trainees will participate, depending upon interests and experience, in individually designed didactic (courses, workshops, journal clubs) programs to develop needed background, specialized technical skills, and communication skills in preparation for an independent research career. All trainees will also receive training in the ethical conduct of research appropriate for whether they are primary focused on clinical vs. laboratory-based research. Procedures are described to select, evaluate, and counsel trainees. We have enjoyed reasonable success in identifying excellent minority participants in the program and efforts to further strengthen this aspect of our program are described. This program has, and will continue to, build upon the long tradition of excellent basic and clinical neuroscience at Washington University toward the objective of training the next generation of clinician scientists dedicated to understanding and treating disorders of the nervous system.

Public Health Relevance

Project narrative: The purpose of this T32 training grant is to provide basic laboratory and clinical research training to neurologists, neurosurgeons, and neuropathologists who are completing their clinical training. The research training should allow them to ultimately perform research with a goal of better understanding and developing treatments for diseases and disorders of the nervous system.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
2T32NS007205-31
Application #
8265428
Study Section
Special Emphasis Panel (ZNS1-SRB-P (63))
Program Officer
Korn, Stephen J
Project Start
1982-07-01
Project End
2017-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
31
Fiscal Year
2012
Total Cost
$258,906
Indirect Cost
$19,458
Name
Washington University
Department
Neurology
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Hawasli, Ammar H; Kim, DoHyun; Ledbetter, Noah M et al. (2016) Influence of White and Gray Matter Connections on Endogenous Human Cortical Oscillations. Front Hum Neurosci 10:330
Gratton, Caterina; Laumann, Timothy O; Gordon, Evan M et al. (2016) Evidence for Two Independent Factors that Modify Brain Networks to Meet Task Goals. Cell Rep 17:1276-1288
Smithson, Laura J; Anastasaki, Corina; Chen, Ran et al. (2016) Contextual signaling in cancer. Semin Cell Dev Biol 58:118-26
Hawasli, Ammar H; Chicoine, Michael R; Dacey Jr, Ralph G (2015) Choosing Wisely: a neurosurgical perspective on neuroimaging for headaches. Neurosurgery 76:1-5; quiz 6
Arias, Eric J; Vajapey, Sravya; Reynolds, Matthew R et al. (2015) Utility of Screening for Cerebral Vasospasm Using Digital Subtraction Angiography. Stroke 46:3137-41
Solga, Anne C; Pong, Winnie W; Kim, Keun-Young et al. (2015) RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth. Neoplasia 17:776-88
Guilliams, Kristin P; Fields, Melanie E; Hulbert, Monica L (2015) Higher-than-expected prevalence of silent cerebral infarcts in children with hemoglobin SC disease. Blood 125:416-7
Hawasli, Ammar H; Chang, Jodie; Reynolds, Matthew R et al. (2015) Transfer of the brachialis to the anterior interosseous nerve as a treatment strategy for cervical spinal cord injury: technical note. Global Spine J 5:110-7
Hawasli, Ammar H; Hullar, Timothy E; Dorward, Ian G (2015) Idiopathic scoliosis and the vestibular system. Eur Spine J 24:227-33
Lundin, Jessica I; Checkoway, Harvey; Criswell, Susan R et al. (2014) Screening for early detection of parkinsonism using a self-administered questionnaire: a cross-sectional epidemiologic study. Neurotoxicology 45:232-7

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