The goal of this application is to provide highly focused training in Systems Neuroscience at Yale University School of Medicine, with special emphasis on the Mammalian Cortex. The philosophy of this program is to preserve and foster integrative approaches to neurobiology that will interface with molecular genetics and clinical medicine with respect to development, organization, function and plasticity of the mammalian brain. Forty-two (42) faculty from 12 basic and clinical departments are participants in this multidisciplinary program. The program offers both depth and breadth. The depth derives from its unique substantive focus on cortical circuits of the rodent, primate and human brain. The breadth of the program derives from the diversity of approaches, spanning molecular, developmental, systems, theory and cognitive neuroscience. Faculty interests span cortical morphogenesis and axon guidance mechanisms in embryos to memory decline and stroke in elderly humans. Methodologies include cloning;cell culture;immunocytochemistry;in situ hybridization;electron and two photon microscopy;voltage clamp and whole cell recording;calcium and other forms of optical imaging;biochemistry and molecular analyses;psycho-pharmacology;rodent, monkey and human behavior;in vivo extracellular recording in behaving animals;and fMRI and PET imaging in human subjects. Two predoctoral and two postdoctoral positions are requested. Trainees are selected from a variety of backgrounds in biological sciences on the basis of their potential for excellence and leadership in research by an Admissions Committee (predocs) or Executive Committee (postdocs). Mentors are Ph.D.s and M.D.s. with NINDS grants and/or NINDS related research foci. Training includes coursework, intensive research apprentice-ship, structured seminar programs, and laboratory and departmental presentations of research progress.

Public Health Relevance

This training program fosters education on brain disorders such as dyslexia, autism, Tourette's Syndrome, Attention Deficit Hyperactivity Disorder, epilepsy, cerebral palsy, dementias (e.g., Alzheimer's and Huntington's diseases), and stroke. We actively encourage and successfully accomplish the translation of basic research findings to further our understanding of the cause and cure of human brain disorders.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Korn, Stephen J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
Schools of Medicine
New Haven
United States
Zip Code
Farr, Olivia M; Zhang, Sheng; Hu, Sien et al. (2014) The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults. Int J Neuropsychopharmacol 17:1177-91
Burbridge, Timothy J; Xu, Hong-Ping; Ackman, James B et al. (2014) Visual circuit development requires patterned activity mediated by retinal acetylcholine receptors. Neuron 84:1049-64
Ackman, James B; Crair, Michael C (2014) Role of emergent neural activity in visual map development. Curr Opin Neurobiol 24:166-75
Farr, Olivia M; Hu, Sien; Matuskey, David et al. (2014) The effects of methylphenidate on cerebral activations to salient stimuli in healthy adults. Exp Clin Psychopharmacol 22:154-65
Seo, Hyojung; Cai, Xinying; Donahue, Christopher H et al. (2014) Neural correlates of strategic reasoning during competitive games. Science 346:340-3
Li, Hong; Fertuzinhos, Sofia; Mohns, Ethan et al. (2013) Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission. Neuron 79:970-86
Anderson, L C; Bolling, D Z; Schelinski, S et al. (2013) Sex differences in the development of brain mechanisms for processing biological motion. Neuroimage 83:751-60
Donahue, Christopher H; Seo, Hyojung; Lee, Daeyeol (2013) Cortical signals for rewarded actions and strategic exploration. Neuron 80:223-34
Gamo, N J; Duque, A; Paspalas, C D et al. (2013) Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction. Transl Psychiatry 3:e328
Zagha, Edward; Casale, Amanda E; Sachdev, Robert N S et al. (2013) Motor cortex feedback influences sensory processing by modulating network state. Neuron 79:567-78

Showing the most recent 10 out of 31 publications