This application is for "highly-focused postdoctoral training". The objectives are to: 1) Provide outstanding postdoctoral training in basic research on molecular structure and physiological function of electrical and chemical synapses;2) Capitalize on the synergism and collaboration of participating faculty;3) Relate basic science findings to clinical problems;and 4) Train members of underrepresented minority groups. Strategies to these ends are to: 1) Restrict training faculty to a small, highly-interactive group;2) Recruit and select top quality trainees;3) Actively recruit minority trainees;4) Mandate attendance at departmental seminars, works-in-progress presentations and journal clubs;and 5) Promote collaborative projects with more than one mentor. Training areas will be: i) Connexins: Structure/Function and Electrical Synaptic Transmission. Studies include mechanisms of connexin channel gating and permeability, trafficking, regulation of expression, physiological roles of channels and hemichannels and mechanisms of diseases, //) Molecular/Cellular Physiology and Biophysics of Chemically Mediated Synaptic Transmission. Studies include glutamate and GABA receptor structure-function, pharmacology and trafficking, regulation by kinases, role of receptors in delayed neurodegeneration, inhibitory-excitatory neuron communication and neuronal integration, Hi) Mechanisms of Synaptic Plasticity. Studies include mechanisms of LTP and LTD, role of endogenous cannabinoids and kinases, receptor distribution, cycling and synaptic plasticity at the systems level. Research in the Dominick P. Purpura Department of Neuroscience continues to flourish, with the addition of 6 new faculty members since the last submission. Past and present trainees have been highly productive and show a high level of retention in biomedical research. The College continues to actively support graduate and postgraduate education. Trainees will carry out research under the primary supervision of participating faculty, with an emphasis on collaborative projects that extend the boundaries beyond a single laboratory. Bioethics and scientific conduct are a regular part of training. Trainees are recruited at national scientific meetings, especially the Society for Neuroscience, by announcements in Peterson's Guide and programs published by the Association of Neuroscience Departments/Programs. Additional efforts at minority recruitment involve participation at meetings organized for minority students. Trainees are encouraged to take full advantage of the multiplicity of scientific opportunities in the College as a whole.

Public Health Relevance

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS007439-15
Application #
8465915
Study Section
Special Emphasis Panel (ZNS1-SRB-P (47))
Program Officer
Korn, Stephen J
Project Start
1998-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
15
Fiscal Year
2013
Total Cost
$138,054
Indirect Cost
$17,041
Name
Albert Einstein College of Medicine
Department
Neurosciences
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Sanchez, Helmuth A; Slavi, Nefeli; Srinivas, Miduturu et al. (2016) Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels. J Gen Physiol 148:25-42
Ben-Simon, Yoav; Rodenas-Ruano, Alma; Alviña, Karina et al. (2015) A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity. Cell Rep 12:396-404
Stout Jr, Randy F; Snapp, Erik Lee; Spray, David C (2015) Connexin Type and Fluorescent Protein Fusion Tag Determine Structural Stability of Gap Junction Plaques. J Biol Chem 290:23497-514
Bejarano, Eloy; Yuste, Andrea; Patel, Bindi et al. (2014) Connexins modulate autophagosome biogenesis. Nat Cell Biol 16:401-14
Sanchez, Helmuth A; Bienkowski, Rick; Slavi, Nefeli et al. (2014) Altered inhibition of Cx26 hemichannels by pH and Zn2+ in the A40V mutation associated with keratitis-ichthyosis-deafness syndrome. J Biol Chem 289:21519-32
Sanchez, Helmuth A; Verselis, Vytas K (2014) Aberrant Cx26 hemichannels and keratitis-ichthyosis-deafness syndrome: insights into syndromic hearing loss. Front Cell Neurosci 8:354
Sanchez, Helmuth A; Villone, Krista; Srinivas, Miduturu et al. (2013) The D50N mutation and syndromic deafness: altered Cx26 hemichannel properties caused by effects on the pore and intersubunit interactions. J Gen Physiol 142:3-22
Negoro, Hiromitsu; Lutz, Sarah E; Liou, Louis S et al. (2013) Pannexin 1 involvement in bladder dysfunction in a multiple sclerosis model. Sci Rep 3:2152
Lutz, Sarah E; González-Fernández, Estibaliz; Ventura, Juan Carlos Chara et al. (2013) Contribution of pannexin1 to experimental autoimmune encephalomyelitis. PLoS One 8:e66657
Lutz, Sarah E; Raine, Cedric S; Brosnan, Celia F (2012) Loss of astrocyte connexins 43 and 30 does not significantly alter susceptibility or severity of acute experimental autoimmune encephalomyelitis in mice. J Neuroimmunol 245:8-14

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