This competitive renewal proposal is a request for continued funding of a broadly based pre- and postdoctoral training program in General Motor Control Mechanisms and Disease from Northwestern University. The program is directed by D. James Surmeier, PhD with the assistance of Indira Raman, PhD (Associate Director) and a Steering Committee. Trainees will conduct their research under the guidance of 43 preceptors working in motor control research from 14 departments spanning the Chicago and Evanston campuses of Northwestern University. The proposal requests support for 5 postdoctoral and 3 predoctoral trainees. Postdoctoral trainees will be selected on the basis of previous training and research plan. Predoctoral trainees will be selected from Northwestern University's Interdepartmental Neuroscience PhD Program (NUIN) on the basis of performance in courses, laboratory rotations and the relevance of dissertation research to the goals of the training program. A concerted effort will be made to continue recruiting minorities to the program. The program offers a broad range of interdisciplinary research and training opportunities in the neuroscience of somatic and autonomic motor control. The research of participating preceptors spans molecular, cellular, systems, clinical, behavioral and computational neuroscience. The preceptor faculty will assist and monitor trainee progress through formal advising and evaluations, through the classroom and through informal discussions (in journal clubs, lab meetings and research clubs). An important feature of the training program is that it brings together researchers in fundamental and clinical neurocience, providing a highly productive, interdisciplinary research environment for trainees in motor control and related motor system diseases at Northwestern University. In addition to providing research training, the program will help trainees develop skills in written and oral communication, grant writing/grantsmanship, networking and career development. Instilling a clear awareness of ethical issues facing neuroscientists and responsible conduct in science will be another training goal.

Public Health Relevance

Diseases such as Parkinson's Disease, which impairs the ability of the patient to appropriately control their movements, are extremely debilitating and severely compromise the quality of life experienced for those afflicted. This Training Program seeks to provide young predoctoral and postdoctoral scientists the training they will need to become leaders in the field of motor control research. By understanding the basic processes involved in the execution of normal movement, it will hopefully be possible to also understand what goes wrong in diseases affecting the motor system and to develop treatment strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
3T32NS041234-13S1
Application #
8699467
Study Section
Program Officer
Korn, Stephen J
Project Start
2013-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
13
Fiscal Year
2013
Total Cost
$45,132
Indirect Cost
$3,343
Name
Northwestern University at Chicago
Department
Physiology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Wong, Yvette C; Ysselstein, Daniel; Krainc, Dimitri (2018) Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis. Nature 554:382-386
Cherry, Jonathan J; DiDonato, Christine J; Androphy, Elliot J et al. (2017) In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels. PLoS One 12:e0185079
Chu, Hong-Yuan; McIver, Eileen L; Kovaleski, Ryan F et al. (2017) Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons. Neuron 95:1306-1318.e5
Burbulla, Lena F; Song, Pingping; Mazzulli, Joseph R et al. (2017) Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease. Science 357:1255-1261
Valdez, Clarissa; Wong, Yvette C; Schwake, Michael et al. (2017) Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients. Hum Mol Genet 26:4861-4872
Glajch, Kelly E; Kelver, Daniel A; Hegeman, Daniel J et al. (2016) Npas1+ Pallidal Neurons Target Striatal Projection Neurons. J Neurosci 36:5472-88
Wong, Yvette C; Krainc, Dimitri (2016) Lysosomal trafficking defects link Parkinson's disease with Gaucher's disease. Mov Disord 31:1610-1618
Cooper, Garry; Lasser-Katz, Efrat; Simchovitz, Alon et al. (2015) Functional segregation of voltage-activated calcium channels in motoneurons of the dorsal motor nucleus of the vagus. J Neurophysiol 114:1513-20
Suter, Benjamin A; Shepherd, Gordon M G (2015) Reciprocal interareal connections to corticospinal neurons in mouse M1 and S2. J Neurosci 35:2959-74
Rafalovich, Igor V; Melendez, Alexandria E; Plotkin, Joshua L et al. (2015) Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses. Cell Rep 13:1336-1342

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