This revised submission requests renewed support for an Institutional Postdoctoral Training Program, to enable recruitment and education of four Trainees per year for careers in research areas germane to the neurobiology, co-morbidities and cure of human epilepsy. The proposed training will take place in the laboratories of 12 preceptors from five departments, and will include Program-specific courses and clinical-translational field trips, as well as seminars, discussion groups and symposia. The first four years of this Program have been rewarding, as the eight Program graduates all remain in Academia: Two are now Assistant Professors in the tenure track, one is a faculty instructor, two are faculty in partially-independent positions at UCI, and two are pursuing additional post-doctoral fellowships to round out their education in epilepsy research. Altogether, twelve excellent Trainees have been enrolled to date, including two of under-represented groups, one MD and sevenwomen. These initial outcome data, together with the comprehensive restructuring of the Program, the addition of Program-specific courses and clinic-oriented field trips, and the recent availability of an MD trainee pool in the Department of Neurosurgery, will enable this Program to provide postdoctoral PhDs and MDs with a structured and nurturing training environment for careers in research relevant to epilepsy. Although epilepsy is the third most common chronic brain disorder, it remains relatively understudied, and the current Program is one of only two epilepsy-focused postdoctoral Training Programs in the U.S.

Public Health Relevance

This program is designed to train scientists and doctors in the study of Epilepsy. Epilepsy is the third most common chronic brain disorder, impacting the lives of millions in the U.S., yet remains poorly understood. The program will enable talented young people to learn how to conduct studies that will uncover the origin of Epilepsy, and help prevent and cure this disease.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZNS1-SRB-P (47))
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Korn, Stephen J
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University of California Irvine
Anatomy/Cell Biology
Schools of Medicine
United States
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Curran, Megan M; Haddad, Elizabeth; Patterson, Katelin P et al. (2018) Epilepsy-predictive magnetic resonance imaging changes following experimental febrile status epilepticus: Are they translatable to the clinic? Epilepsia 59:2005-2018
Stevenson, Rebecca F; Zheng, Jie; Mnatsakanyan, Lilit et al. (2018) Hippocampal CA1 gamma power predicts the precision of spatial memory judgments. Proc Natl Acad Sci U S A 115:10148-10153
Bolton, Jessica L; Molet, Jenny; Regev, Limor et al. (2018) Anhedonia Following Early-Life Adversity Involves Aberrant Interaction of Reward and Anxiety Circuits and Is Reversed by Partial Silencing of Amygdala Corticotropin-Releasing Hormone Gene. Biol Psychiatry 83:137-147
Pirbhoy, Patricia Salgado; Farris, Shannon; Steward, Oswald (2017) Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways. Learn Mem 24:341-357
Patterson, Katelin P; Barry, Jeremy M; Curran, Megan M et al. (2017) Enduring Memory Impairments Provoked by Developmental Febrile Seizures Are Mediated by Functional and Structural Effects of Neuronal Restrictive Silencing Factor. J Neurosci 37:3799-3812
Hall, Alicia M; Brennan, Gary P; Nguyen, Tiffany M et al. (2017) The Role of Sirt1 in Epileptogenesis. eNeuro 4:
Curran, Megan M; Sandman, Curt A; Poggi Davis, Elysia et al. (2017) Abnormal dendritic maturation of developing cortical neurons exposed to corticotropin releasing hormone (CRH): Insights into effects of prenatal adversity? PLoS One 12:e0180311
Brennan, Gary P; Dey, Deblina; Chen, Yuncai et al. (2016) Dual and Opposing Roles of MicroRNA-124 in Epilepsy Are Mediated through Inflammatory and NRSF-Dependent Gene Networks. Cell Rep 14:2402-12
Barry, Jeremy M; Sakkaki, Sophie; Barriere, Sylvain J et al. (2016) Temporal Coordination of Hippocampal Neurons Reflects Cognitive Outcome Post-febrile Status Epilepticus. EBioMedicine 7:175-90
Wang, Weisheng; Kantorovich, Svetlana; Babayan, Alex H et al. (2016) Estrogen's Effects on Excitatory Synaptic Transmission Entail Integrin and TrkB Transactivation and Depend Upon ?1-integrin function. Neuropsychopharmacology 41:2723-32

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