The training program in Integrative Neuroscience in Health and Disease is designed to provide broad-based training for both pre- and postdoctoral fellows. Our goals are to 1) train neuroscientists who have a broad understanding and acquaintance with the sub-fields of neuroscience and 2) provide financial support to collaborative research projects that join laboratories with differing intellectual and/or experimental expertise. The program builds upon a 5 year joint program between the University of Medicine and Dentistry of New Jersey and Rutgers University in Newark. Trainees, therefore, will have access to the facilities of both schools, which lie within 5 blocks of one another, and the basic science and clinical seminars and courses which they offer. The training faculty has expertise in all aspects of neuroscience, biology, and neurology. The breadth of the research ongoing in the two institutions will ensure exposure to multiple experimental approaches and multiple mentors. Additionally, there are intentional opportunities throughout the program for researchers in different sub-fields to interact. Although the faculty is experienced in successful mentoring, the program will have advisors for both pre- and post-doctorates, as well as student and postdoctoral representatives to ensure a high quality of supervision, a fulfilling training experience, and successful career advancement. Postdoctoral training will be enhanced by the Office of Postdoctoral Affairs. We are requesting support for 2 pre-doctoral fellows each year and 2 postdoctoral fellows in year 1 and 3 in each year thereafter. Each trainee will be supported for 2 years during which time they will be assisted in applying for fellowships or other grant support. Attendance and presentation at research meetings, participation in teaching activities, submission of publications and support of peers and colleagues will be strongly and actively encouraged. Relevance: This grant will train neuroscientists who will work on the entire breadth of neurological disease including degenerations, drug addiction, obesity, epilepsy, pain and language and learning disorders. It promotes interaction among all the fields of neuroscience from behavior to molecular neurobiology to stimulate innovative and therapeutic breakthroughs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS051157-05
Application #
8080816
Study Section
NST-2 Subcommittee (NST)
Program Officer
Korn, Stephen J
Project Start
2007-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
5
Fiscal Year
2011
Total Cost
$137,709
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Neurosciences
Type
Schools of Medicine
DUNS #
623946217
City
Newark
State
NJ
Country
United States
Zip Code
07107
Kung, Frank; Wang, Jianfeng; Perez-Castillejos, Raquel et al. (2015) Position along the nasal/temporal plane affects synaptic development by adult photoreceptors, revealed by micropatterning. Integr Biol (Camb) 7:313-23
Buono, Krista D; Goodus, Matthew T; Guardia Clausi, Mariano et al. (2015) Mechanisms of mouse neural precursor expansion after neonatal hypoxia-ischemia. J Neurosci 35:8855-65
Cote, Samantha R; Kuzhikandathil, Eldo V (2015) Chronic levodopa treatment alters expression and function of dopamine D3 receptor in the MPTP/p mouse model of Parkinson's disease. Neurosci Lett 585:33-7
Tobón, Krishna E; Catuzzi, Jennifer E; Cote, Samantha R et al. (2015) Post-transcriptional regulation of dopamine D1 receptor expression in caudate-putamen of cocaine-sensitized mice. Eur J Neurosci 42:1849-57
Roland, Jessica J; Stewart, Amanda L; Janke, Kellie L et al. (2014) Medial septum-diagonal band of Broca (MSDB) GABAergic regulation of hippocampal acetylcholine efflux is dependent on cognitive demands. J Neurosci 34:506-14
Cote, Samantha R; Kuzhikandathil, Eldo V (2014) Inýývitro and inýývivo characterization of the agonist-dependent D3 dopamine receptor tolerance property. Neuropharmacology 79:359-67
Roland, J J; Janke, K L; Servatius, R J et al. (2014) GABAergic neurons in the medial septum-diagonal band of Broca (MSDB) are important for acquisition of the classically conditioned eyeblink response. Brain Struct Funct 219:1231-7
Shrirao, Anil B; Kung, Frank H; Yip, Derek et al. (2014) Vacuum-assisted fluid flow in microchannels to pattern substrates and cells. Biofabrication 6:035016
Cote, Samantha R; Chitravanshi, Vineet C; Bleickardt, Carina et al. (2014) Overexpression of the dopamine D3 receptor in the rat dorsal striatum induces dyskinetic behaviors. Behav Brain Res 263:46-50
Buono, Krista D; Vadlamuri, Daimler; Gan, Qiong et al. (2012) Leukemia inhibitory factor is essential for subventricular zone neural stem cell and progenitor homeostasis as revealed by a novel flow cytometric analysis. Dev Neurosci 34:449-62

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