This proposal aims to renew funding for a pre- and post-doctoral training program in NEURAL MICROCIRCUITS. The overall goal of this program is to train a cadre of outstanding researchers who will have: 1) an in-depth understanding of the principles that underlie the function of NEURAL MICROCIRCUITS in a broad range of nervous system function, and;2) extensive research training in modern experimental approaches to analyzing NEURAL MICROCIRCUITS. Our program prepares trainees to conduct contemporary neuroscience research that bridges the gaps in understanding between synapses, single neurons, NEURAL MICROCIRCUITS and behavior. The program enhances basic pre- and postdoctoral training with an advanced NEURAL MICROCIRCUITS graduate course, a monthly journal club, and an annual DYNAMICS OF NEURAL MICROCIRCUITS symposium. In our inaugural funding period we have established a vigorous training program where new techniques, findings, and ideas are freely exchanged among the faculty, postdoctoral fellows and predoctoral students that fosters interaction and collaboration. Our success to date in achieving our ambitious training goals results from an outstanding pool of applicants and the strength of the interactive program faculty in a broad range of areas relevant to NEURAL MICROCIRCUITS. An outstanding research environment and excellent facilities are available at UCLA, with 24 faculty with highly active research programs with state of the art laboratories funded by significant extramural support. A broad range of core facilities are available that offer assistance, such as in molecular biology including in the making of viruses and of transgenic mice and advanced optics. This training program provides unique research training in NEURAL MICROCIRCUITS, which is fundamental for an understanding of the function and behavior of the CNS and for the development of therapeutic strategies for the treatment of pathological changes in the CNS. !

Public Health Relevance

Following training in the NEURAL MICROCIRCUITS program, predoctoral students and postdoctoral fellows will be uniquely poised to investigate and ultimately understand the NEURAL MICROCIRCUITS that are a critical link in understanding how behavior results from neurons and their interconnections. Such knowledge is essential to explain how nervous system disease results from neuronal dysfunction.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS058280-07
Application #
8436165
Study Section
Special Emphasis Panel (ZNS1-SRB-P (63))
Program Officer
Korn, Stephen J
Project Start
2007-07-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
7
Fiscal Year
2013
Total Cost
$261,264
Indirect Cost
$16,508
Name
University of California Los Angeles
Department
Neurosciences
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Goel, Anubhuti; Buonomano, Dean V (2014) Timing as an intrinsic property of neural networks: evidence from in vivo and in vitro experiments. Philos Trans R Soc Lond B Biol Sci 369:20120460
Jones, Ryan T; Faas, Guido C; Mody, Istvan (2014) Intracellular bicarbonate regulates action potential generation via KCNQ channel modulation. J Neurosci 34:4409-17
Condro, Michael C; White, Stephanie A (2014) Distribution of language-related Cntnap2 protein in neural circuits critical for vocal learning. J Comp Neurol 522:169-85
Rogerson, Thomas; Cai, Denise J; Frank, Adam et al. (2014) Synaptic tagging during memory allocation. Nat Rev Neurosci 15:157-69
Fanselow, Michael S; Zelikowsky, Moriel; Perusini, Jennifer et al. (2014) Isomorphisms between psychological processes and neural mechanisms: from stimulus elements to genetic markers of activity. Neurobiol Learn Mem 108:5-13
Goel, Anubhuti; Buonomano, Dean V (2013) Chronic electrical stimulation homeostatically decreases spontaneous activity, but paradoxically increases evoked network activity. J Neurophysiol 109:1824-36
Dellal, Shlomo S; Luo, Ray; Otis, Thomas S (2012) GABAA receptors increase excitability and conduction velocity of cerebellar parallel fiber axons. J Neurophysiol 107:2958-70
Halladay, L R; Blair, H T (2012) The role of mu-opioid receptor signaling in the dorsolateral periaqueductal gray on conditional and unconditional responding to threatening and aversive stimuli. Neuroscience 216:82-93
Itri, Jason N; Vosko, Andrew M; Schroeder, Analyne et al. (2010) Circadian regulation of a-type potassium currents in the suprachiasmatic nucleus. J Neurophysiol 103:632-40
Bradley, Jonathan; Luo, Ray; Otis, Thomas S et al. (2009) Submillisecond optical reporting of membrane potential in situ using a neuronal tracer dye. J Neurosci 29:9197-209