Multidisciplinary approaches drive progress in the neurosciences perhaps more than in most other areas of biomedical research. The next generation of research neuroscientists, therefore, must be equipped with a multi-faceted skill set if they are to transition to successful independent careers and contribute meaningfully to the field. To meet this challenge, we propose a new predoctoral Synapse Neurobiology Training Program (SNTP) at Tufts University School of Medicine that will provide in-depth, multidisciplinary research education of 4 trainees in the area of synaptic function-a particular strength of the Tufts neuroscience faculty. The synapse forms the foundation of nervous system function, and research on synapses is, arguably, one of the most interdisciplinary areas in modern neurobiology. The SNTP training plan, thus, includes several mechanisms that position trainees to become leading neuroscientists, working at the interface between traditional disciplines: ? Each trainee will be co-mentored by two SNTP faculty members who provide training in distinct yet complementary areas. ? Through subsidized, one-on-one training in imaging, bioinformatics, electrophysiology, and animal behavior methods (provided via the core facilities and PhD-level Managers in the NINDS-funded Center for Neuroscience Research at Tufts), SNTP trainees will acquire the state-of-the-art tools and training required for an effective and influential multidisciplinary approach. ? Innovative quantitative skills and techniques courses and individualized training plans will further aid each SNTP trainee in mastering the necessary skills to accomplish his/her research career goals. ? Frequent opportunities for individual interactions with visiting speakers will provide SNTP trainees with further exposure to new methodologies and ideas as well as advice and guidance.

Public Health Relevance

Myriad disorders of the nervous system-e.g., epilepsy, ataxia, Parkinson's Disease, dementia, and stroke- involve fundamental alterations in synaptic function;dozens of mutations and polymorphisms in pre and postsynaptic receptors and ion channels are implicated in human neurological diseases. The development of future therapeutic approaches for such diseases will increasingly rely on advances made by a continuing cadre of investigators trained to unravel the fundamental mechanisms underlying synapse function. The goal of the SNTP is, thus, to ensure that our trainees have the tools and training required to shape the future of neuroscience through enhanced understanding of synaptic function in health and disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
3T32NS061764-05S1
Application #
8704483
Study Section
Program Officer
Korn, Stephen J
Project Start
2009-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2013
Total Cost
$29,003
Indirect Cost
$2,139
Name
Tufts University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111
Hanson, Elizabeth; Danbolt, Niels Christian; Dulla, Chris G (2016) Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust. Neurobiol Dis 89:157-68
Trattnig, Sarah M; Gasiorek, Agnes; Deeb, Tarek Z et al. (2016) Copper and protons directly activate the zinc-activated channel. Biochem Pharmacol 103:109-17
Armbruster, Moritz; Hanson, Elizabeth; Dulla, Chris G (2016) Glutamate Clearance Is Locally Modulated by Presynaptic Neuronal Activity in the Cerebral Cortex. J Neurosci 36:10404-10415
Sun, Xinxin; Pinacho, Raquel; Saia, Gregory et al. (2015) Transcription factor Sp4 regulates expression of nervous wreck 2 to control NMDAR1 levels and dendrite patterning. Dev Neurobiol 75:93-108
Hickman, Tyler T; Liberman, M Charles; Jacob, Michele H (2015) Adenomatous Polyposis Coli Protein Deletion in Efferent Olivocochlear Neurons Perturbs Afferent Synaptic Maturation and Reduces the Dynamic Range of Hearing. J Neurosci 35:9236-45
Hanson, Elizabeth; Armbruster, Moritz; Cantu, David et al. (2015) Astrocytic glutamate uptake is slow and does not limit neuronal NMDA receptor activation in the neonatal neocortex. Glia 63:1784-96
Ng, Seng Kah; Higashimori, Haruki; Tolman, Michaela et al. (2015) Suppression of adenosine 2a receptor (A2aR)-mediated adenosine signaling improves disease phenotypes in a mouse model of amyotrophic lateral sclerosis. Exp Neurol 267:115-22
Pinacho, Raquel; Saia, Gregory; Meana, J Javier et al. (2015) Transcription factor SP4 phosphorylation is altered in the postmortem cerebellum of bipolar disorder and schizophrenia subjects. Eur Neuropsychopharmacol 25:1650-60
Jackson, F Rob; Ng, Fanny S; Sengupta, Sukanya et al. (2015) Glial cell regulation of rhythmic behavior. Methods Enzymol 552:45-73
Pinacho, Raquel; Saia, Gregory; Fusté, Montserrat et al. (2015) Phosphorylation of transcription factor specificity protein 4 is increased in peripheral blood mononuclear cells of first-episode psychosis. PLoS One 10:e0125115

Showing the most recent 10 out of 36 publications