This second competing renewal application of a T32 program initiated in 2002 retains as its goal to provide experiential training in molecular and mechanistic research to post- DVM/VMD candidates with residency specialization. Graduates from the program will have unique skills to bridge basic research to in vivo translation with impact on human and animal health in a time of emerging diseases, biosecurity, and One Medicine. The training program builds on a robust initial phase of residency training funded by non-T32 sources to merge seamlessly to the T32-supported mentored research training emphasizing modern multidisciplinary methods linked to translational application. The program also stresses critical thinking in experimental design and data interpretation, scientific writing, publication, communication skills, and the ethical conduct of research. The desired outcome of this training program is production of DVM/VMD scientists who will become successful NIH-funded principal investigators able to respond to national human and animal health priorities. The program is guided by experienced leadership, counseled by an external advisory committee comprised of expert T32 Program Directors, populated with diverse faculty skilled in research mentorship. Major indicators of success in the first 9 years of this award include: (1) successful recruitment and retention of trainees since inception;(2) attainment of the PhD by all 10 eligible trainees to date--6 of whom have received NIH K career development awards, 8 of whom are appointed in junior faculty level positions focusing on research;and, (3) the generation of ~75 scientific publications by T32 trainees. Here we apply for support to continue this productive training program at its present level.
This research training program requests resources for stipend and tuition to support graduate training for veterinarians in public and human health related fields. As many emerging infectious diseases of humans are spread from and/or are infectious to animals, and as many human cancers and spontaneously occurring diseases also exist in animals, or are studied in animal models, veterinarians trained in research are essential to advancement of public health.
|Regan, Daniel; Guth, Amanda; Coy, Jonathan et al. (2016) Cancer immunotherapy in veterinary medicine: Current options and new developments. Vet J 207:20-8|
|Aanstoos, Megan E; Regan, Daniel P; Rose, Ruth J et al. (2016) Do Mesenchymal Stromal Cells Influence Microscopic Residual or Metastatic Osteosarcoma in a Murine Model? Clin Orthop Relat Res 474:707-15|
|Hoover, Clare E; Davenport, Kristen A; Henderson, Davin M et al. (2016) Detection and Quantification of CWD Prions in Fixed Paraffin Embedded Tissues by Real-Time Quaking-Induced Conversion. Sci Rep 6:25098|
|Henderson, Davin M; Davenport, Kristen A; Haley, Nicholas J et al. (2015) Quantitative assessment of prion infectivity in tissues and body fluids by real-time quaking-induced conversion. J Gen Virol 96:210-9|
|Richardson, Mike A; Furlani, Robert E; Podell, Brendan K et al. (2015) Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives. Tetrahedron Lett 56:3406-3409|
|Henderson, Davin M; Denkers, Nathaniel D; Hoover, Clare E et al. (2015) Longitudinal Detection of Prion Shedding in Saliva and Urine by Chronic Wasting Disease-Infected Deer by Real-Time Quaking-Induced Conversion. J Virol 89:9338-47|
|Ackart, David F; Hascall-Dove, Laurel; Caceres, Silvia M et al. (2014) Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis. Pathog Dis 70:359-69|
|Ackart, David F; Lindsey, Erick A; Podell, Brendan K et al. (2014) Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules. Pathog Dis 70:370-8|
|Podell, Brendan K; Ackart, David F; Obregon-Henao, Andres et al. (2014) Increased severity of tuberculosis in Guinea pigs with type 2 diabetes: a model of diabetes-tuberculosis comorbidity. Am J Pathol 184:1104-18|
|Jalkanen, Aimee L; Coleman, Stephen J; Wilusz, Jeffrey (2014) Determinants and implications of mRNA poly(A) tail size--does this protein make my tail look big? Semin Cell Dev Biol 34:24-32|
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