? This proposal describes a short-term, summer training program for medical students focused on exposing students to career opportunities in basic and clinical research related to diabetes, obesity, endocrine disorders, metabolic diseases, and kidney diseases. This application addresses 2 Specific Aims:
Aim 1 : To provide hands-on training in basic and clinical Endocrine-based research to medical students in a structured mentored environment.
Aim 2 : To provide an interactive, educational experience that introduces medical students the fundamental skills necessary for basic, translational, and clinical Endocrine-based research. The training program will include didactic instruction as well as a hands-on-research experience under the direction of a team of experienced basic and clinical research scientists centered on a core of NIDDK-funded investigators and collaborating faculty. These faculty have long-standing success in mentoring medical and graduate students and post-doctoral fellows. Students who have completed at least one year of medical school will be eligible to apply for this 10-week training program. Trainees will be selected based upon their academic performance, letters of recommendation, and matching their research interests and career goals with suitable mentors. We have been successful in recruiting students from minority, rural, and economically disadvantaged backgrounds. The students will participate in an established 10-week didactic summer program: """"""""From Bench to Bedside: Introduction to Clinical Research"""""""", which included bioethics, as well as Endocrine-specific seminars and journal clubs in basic and clinical research. Students will present posters of their research at the end of the program. The training program will begin with six trainees and increase to ten trainees as the program matures. Over the past 6 years the University of Louisville has increased its commitment to health science research and infrastructure, graduate education, and minority recruitment, making this short-term training program for medical students particularly timely ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
NRSA Short -Term Research Training (T35)
Project #
1T35DK072923-01
Application #
7007795
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
Project Start
2006-05-01
Project End
2011-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
1
Fiscal Year
2006
Total Cost
$37,492
Indirect Cost
Name
University of Louisville
Department
Biochemistry
Type
Schools of Medicine
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292
Ellingwood, Sara S; Cheng, Alan (2018) Biochemical and clinical aspects of glycogen storage diseases. J Endocrinol 238:R131-R141
Muluhngwi, Penn; Richardson, Kirsten; Napier, Joshua et al. (2017) Regulation of miR-29b-1/a transcription and identification of target mRNAs in CHO-K1 cells. Mol Cell Endocrinol 444:38-47
Muluhngwi, Penn; Krishna, Abirami; Vittitow, Stephany L et al. (2017) Tamoxifen differentially regulates miR-29b-1 and miR-29a expression depending on endocrine-sensitivity in breast cancer cells. Cancer Lett 388:230-238
Radde, Brandie N; Ivanova, Margarita M; Mai, Huy Xuan et al. (2016) Nuclear respiratory factor-1 and bioenergetics in tamoxifen-resistant breast cancer cells. Exp Cell Res 347:222-31
Kimbrough, Charles W; Lakshmanan, Jaganathan; Matheson, Paul J et al. (2015) Resveratrol decreases nitric oxide production by hepatocytes during inflammation. Surgery 158:1095-101; discussion 1101
Zhang, Baochun; Crankshaw, Will; Nesemeier, Ryan et al. (2015) Calcium-mediated signaling and calmodulin-dependent kinase regulate hepatocyte-inducible nitric oxide synthase expression. J Surg Res 193:795-801
Winters, Stephen J; Ghooray, Dushan T; Yang, Rong Q et al. (2014) Dopamine-2 receptor activation suppresses PACAP expression in gonadotrophs. Endocrinology 155:2647-57
Klinge, Carolyn M; Radde, Brandie N; Imbert-Fernandez, Yoannis et al. (2011) Targeting the intracellular MUC1 C-terminal domain inhibits proliferation and estrogen receptor transcriptional activity in lung adenocarcinoma cells. Mol Cancer Ther 10:2062-71
Ivanova, Margarita M; Luken, Kristen H; Zimmer, Amber S et al. (2011) Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites. FASEB J 25:1402-16
Klinge, Carolyn M; Riggs, Krista A; Wickramasinghe, Nalinie S et al. (2010) Estrogen receptor alpha 46 is reduced in tamoxifen resistant breast cancer cells and re-expression inhibits cell proliferation and estrogen receptor alpha 66-regulated target gene transcription. Mol Cell Endocrinol 323:268-76