Funds are requested in this application to support the Rochester Training Program in Oral Science. Additional clinician-scientists must be generated for society to take advantage of the rapid and dramatic advances being made in the biomedical sciences. The Center for Oral Biology's training programs have been highly successful in recruiting, training and retaining Oral Science researchers over the past 20+ years. The University of Rochester Medical Center has committed substantial resources to recruit new faculty, to improve our physical plant, and to acquire new technologies. This enhanced commitment to our research environment expands the depth and breadth of training necessary to excel in the biomedical sciences. The University of Rochester has a long history and commitment to training graduate dentists. The overall goal of the Training Program in Oral Science (TPOS) is to provide improved training opportunities for dentist-scientists and oral biologists that will enable them to pursue research careers in dentistry and medicine at academic, federal and industrial organizations. Cross-disciplinary training will focus on the general fields of oral infectious diseases, the cellular and developmental biology of craniofacial structures, with training in clinical/translational approaches to the manifestations of oral disease. TPOS targets the recruitment of dentists who wish to pursue a PhD and dentist-PhDs who want to engage in post-doctoral level training. We will also recruit PhDs and baccalaureate degree-holders pursuing a PhD. In this manner, PhD level scientists will be recruited to the field of Oral Science. Our program features a DST Program for dental students who wish to coordinate clinical studies with PhD training. This novel program partners the excellent clinical programs at Marquette University, the University of Puerto Rico and the University of Kentucky with the PhD programs at the research-intensive University of Rochester Medical Center. Finally, our program will include R90 research education for internationally trained DDS, PhD dual degree holding individuals. The various components of TPOS are integrated through educational options of the Rochester Graduate Program, the clinical training programs of the Eastman Institute for Oral Health, and the clinical/translational educational resources of the Rochester Clinical and Translational Sciences Institute. TPOS trainees are expected to be highly prepared for careers in Oral Science research.

Public Health Relevance

The proposed Training Program aims to prepare scientists and dentists to become leaders in the research of oral disease and oral/facial birth defects. The program will integrate classroom work, research in laboratories and hospitals, and in dental clinics in a multidisciplinary fashion. Our long-term goal is to accelerate the pace at which effective, new treatments for diseases can be brought to the public to lessen suffering and improve lives.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Interdisciplinary Research Training Award (T90)
Project #
5T90DE021985-02
Application #
8277086
Study Section
Special Emphasis Panel (ZDE1-RW (09))
Program Officer
King, Lynn M
Project Start
2011-08-01
Project End
2016-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
2
Fiscal Year
2012
Total Cost
$655,714
Indirect Cost
$44,737
Name
University of Rochester
Department
Microbiology/Immun/Virology
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Lannan, Katie L; Refaai, Majed A; Ture, Sara K et al. (2016) Resveratrol preserves the function of human platelets stored for transfusion. Br J Haematol 172:794-806
Saputo, Sarah; Norman, Kaitlyn L; Murante, Thomas et al. (2016) Complex Haploinsufficiency-Based Genetic Analysis of the NDR/Lats Kinase Cbk1 Provides Insight into Its Multiple Functions in Candida albicans. Genetics 203:1217-33
Cross, Benjamin; Garcia, Ariana; Faustoferri, Roberta et al. (2016) PlsX deletion impacts fatty acid synthesis and acid adaptation in Streptococcus mutans. Microbiology 162:662-71
Kim, Nina; Ramon, Sesquile; Thatcher, Thomas H et al. (2016) Specialized proresolving mediators (SPMs) inhibit human B-cell IgE production. Eur J Immunol 46:81-91
Martinelli, Daniel J; Pavelka Jr, Martin S (2016) The RipA and RipB Peptidoglycan Endopeptidases Are Individually Nonessential to Mycobacterium smegmatis. J Bacteriol 198:1464-75
Cross, Benjamin; Faustoferri, Roberta C; Quivey Jr, Robert G (2016) What are We Learning and What Can We Learn from the Human Oral Microbiome Project? Curr Oral Health Rep 3:56-63
Lannan, Katie L; Sahler, Julie; Kim, Nina et al. (2015) Breaking the mold: transcription factors in the anucleate platelet and platelet-derived microparticles. Front Immunol 6:48
Alzayady, Kamil J; Sebé-Pedrós, Arnau; Chandrasekhar, Rahul et al. (2015) Tracing the Evolutionary History of Inositol, 1, 4, 5-Trisphosphate Receptor: Insights from Analyses of Capsaspora owczarzaki Ca2+ Release Channel Orthologs. Mol Biol Evol 32:2236-53
Quivey Jr, R G; Grayhack, E J; Faustoferri, R C et al. (2015) Functional profiling in Streptococcus mutans: construction and examination of a genomic collection of gene deletion mutants. Mol Oral Microbiol 30:474-95
Miller, James H; Avilés-Reyes, Alejandro; Scott-Anne, Kathy et al. (2015) The collagen binding protein Cnm contributes to oral colonization and cariogenicity of Streptococcus mutans OMZ175. Infect Immun 83:2001-10

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