The highly-interactive, interdisciplinary core of the Consortium (Projects 1-4), focusedon the development of targeted therapeutics for the neurodegenerative disorder, FXTAS, will be greatly enhanced by a post-graduate (T90) training component,the Interdisciplinary Training Program in Neurotherapeutics (ITN). In this non-traditional setting, the principal objective of the T90 will be to further the research effort of the Consortium, by attracting trainees who are intrinsically interested in interdisciplinary research and who will naturally bridge disciplines within the Consortium through inter-project, dual-mentorship. In turn, the Consortium will provide the trainee with an outstanding environment for training in interdisciplinary neuroscience, for it is an environmentthat fully spans both basic and clinical domains. Trainees from diverse disciplines and backgrounds, including chemistry, molecular biology, mouse biology and behavior, cognitive neuroscience and human functional neuroimaging, and clinical neuroscience disciplines (neurology, psychiatry, pediatrics and clinical psychology), will train together in the ITN. The ITNwill emphasize both individualized research training across at least two Consortium laboratories (dual mentorship) and a set of core competencies that spans the entire range of the represented disciplines. The program will target trainees who can be positioned to bridge different laboratories in order to create a new kind of investigator, one who can go beyond traditional roles and lead future mechanistic studies and intervention efforts aimed towards understanding and treating neurogenetic developmental disorders from a truly interdisciplinary perspective. The T90 will provide interdisciplinary research through an Individualized Training Plan, which will consist of five key elements: (1) mentored researchtraining bridging across two distinct projects in the Consortium;(2) participation in a didactic program to develop Core Competencies;(3) observational training in clinical assessments in neurogenetic disorders;(4) participation in selected individualized coursework;and (5) career development activities. In addition to the novel training opportunities provided through the T90, the training will leverage existing training programs in the DCDavis School of Medicine in autism research, clinical and translational research, and the responsible conduct of research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Linked Training Award (TL1)
Project #
5TL1DA024854-05
Application #
8110021
Study Section
Special Emphasis Panel (ZRR1-SRC (99))
Program Officer
Volman, Susan
Project Start
2007-09-30
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
5
Fiscal Year
2011
Total Cost
$110,154
Indirect Cost
Name
University of California Davis
Department
Psychiatry
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Wong, Ling M; Goodrich-Hunsaker, Naomi J; McLennan, Yingratana et al. (2014) Eye movements reveal impaired inhibitory control in adult male fragile X premutation carriers asymptomatic for FXTAS. Neuropsychology 28:571-84
Kim, So-Yeon; Tassone, Flora; Simon, Tony J et al. (2014) Altered neural activity in the 'when' pathway during temporal processing in fragile X premutation carriers. Behav Brain Res 261:240-8
Leow, Alex; Harvey, Danielle; Goodrich-Hunsaker, Naomi J et al. (2014) Altered structural brain connectome in young adult fragile X premutation carriers. Hum Brain Mapp 35:4518-30
Wadell, Paula M; Hagerman, Randi J; Hessl, David R (2013) FRAGILE X SYNDROME: PSYCHIATRIC MANIFESTATIONS, ASSESSMENT AND EMERGING THERAPIES. Curr Psychiatry Rev 9:53-58
Kim, So-Yeon; Hashimoto, Ryu-ichiro; Tassone, Flora et al. (2013) Altered neural activity of magnitude estimation processing in adults with the fragile X premutation. J Psychiatr Res 47:1909-16
Wang, Jun Yi; Hessl, David; Schneider, Andrea et al. (2013) Fragile X-associated tremor/ataxia syndrome: influence of the FMR1 gene on motor fiber tracts in males with normal and premutation alleles. JAMA Neurol 70:1022-9
Schneider, Andrea; Ligsay, Andrew; Hagerman, Randi J (2013) Fragile X syndrome: an aging perspective. Dev Disabil Res Rev 18:68-74
Wang, Jun Yi; Hagerman, Randi J; Rivera, Susan M (2013) A multimodal imaging analysis of subcortical gray matter in fragile X premutation carriers. Mov Disord 28:1278-84
Wang, Jun Yi; Hessl, David; Iwahashi, Christine et al. (2013) Influence of the fragile X mental retardation (FMR1) gene on the brain and working memory in men with normal FMR1 alleles. Neuroimage 65:288-98
Chonchaiya, Weerasak; Au, Jacky; Schneider, Andrea et al. (2012) Increased prevalence of seizures in boys who were probands with the FMR1 premutation and co-morbid autism spectrum disorder. Hum Genet 131:581-9

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