v ,"""""""" ? . The University of Rochester Clinical and Translational ScfenceInstitute (UR CTSI) will be createdas the academic home for clinical andtranslational science, providing a centralized, integrated infrastructure. Under a systemof governance in which the UR CTSI Program Director has authority*over space, faculty, budgets, and other resources related to the CTSI, and in which much of the current GCRC budget is [distributed to CTSI Key Functions in support of these functions, we plan to transformthe two distinct research fields of clinical and translational science into a single new discipline. The goals of this discipline nclude the creation of new knowledge and techniques to diagnose, prevent and treat human disease, and the establishment of an environment that catalyzes iheir application to clinical practice in the community. To achieve these goals, we propose specific aims involving: novel methodologies;pilot studies;upgraded biomedical informatics, epidemiology, research design, ethics, and regulatory support;community engagement;new technology and resource cores;new educational and training programs;an Upstate New York Consortium;and rigorous evaluation and measurement of performance outcomes. Strategic planning for the UR CTSI has been underwayfor several yearsprior to this RFA. Evidence of institutional support ncludes commitment to a new 150,000 sq. ft. Clinical andTranslational Science Building (CTSB) in which faculty conducting clinical and translational researchwill be brought together with students and trainees in existing and new degree-granting programs, with supporting regulatory and administrative functions, and with faculty working in collaborative disciplines such as biostatistics, epidemiology, and biomedical informatics. The Director and Co-Directors of the URCTSI will integrate the clinical and translational science functions contained in the CTSB with those functions locatedat other campus locations, such as functional genomics, other translational resources, and the General Clinical ResearchCenter (GCRC). As an integral part of the CTSI, the GCRC will move into a newly-renovated 10,500 sq ft facility across the street from the CTSB, with enhanced functionality and subject access. As well, the UR CTSI will create two-way synergies with local community groups (school system, faith community, business, foundations) and with other Upstate New York institutions. Further, the UR CTSI will enable the sharing of data across disciplines andacross jinstitutions while assuring the privacy and confidentiality of human subjects. In summary, by coalescing and integrating new facilities with enhanced infrastructure, community and state-wide partnerships, astrong (foundation of existing researchand training, and a fundamentally reorganized administrative structure, the CTSI will transform the conduct of clinical and translational science at URand contribute1nationally to the forging ofthis new discipline. : ,

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Linked Training Award (TL1)
Project #
5TL1RR024135-04
Application #
7689398
Study Section
Special Emphasis Panel (ZRR1-CR-3 (01))
Program Officer
Sawczuk, Andrea
Project Start
2006-09-30
Project End
2011-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
4
Fiscal Year
2009
Total Cost
$935,402
Indirect Cost
Name
University of Rochester
Department
Public Health & Prev Medicine
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Levis, Brooke; Benedetti, Andrea; Riehm, Kira E et al. (2018) Probability of major depression diagnostic classification using semi-structured versus fully structured diagnostic interviews. Br J Psychiatry 212:377-385
Chapman, Lesley M; Ture, Sara K; Field, David J et al. (2017) miR-451 limits CD4+ T cell proliferative responses to infection in mice. Immunol Res 65:828-840
Szpunar, Mercedes J; Belcher, Elizabeth K; Dawes, Ryan P et al. (2016) Sympathetic innervation, norepinephrine content, and norepinephrine turnover in orthotopic and spontaneous models of breast cancer. Brain Behav Immun 53:223-233
Simning, Adam; van Wijngaarden, Edwin; Conwell, Yeates (2015) Overcoming Recruitment Barriers in Urban Older Adults Residing in Congregate Living Facilities. Psychiatry J 2015:824672
Prucha, Michael G; Fisher, Susan G; McIntosh, Scott et al. (2015) Health care workers' knowledge, attitudes and practices on tobacco use in economically disadvantaged dominican republic communities. Int J Environ Res Public Health 12:4060-75
Koehler, Ryan J; Goldblatt, John P; Maloney, Michael D et al. (2015) Assessing Diagnostic Arthroscopy Performance in the Operating Room Using the Arthroscopic Surgery Skill Evaluation Tool (ASSET). Arthroscopy 31:2314-9.e2
Jacob, Michael S; Duffy, Charles J (2014) Might cortical hyper-responsiveness in aging contribute to Alzheimer's disease? PLoS One 9:e105962
Brown, Matthew L; Yukata, Kiminori; Farnsworth, Christopher W et al. (2014) Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus. PLoS One 9:e99656
Abu-Zeitone, Abeer; Peterson, Derick R; Polonsky, Bronislava et al. (2014) Oral contraceptive use and the risk of cardiac events in patients with long QT syndrome. Heart Rhythm 11:1170-5
Rappold, Phillip M; Cui, Mei; Grima, Jonathan C et al. (2014) Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo. Nat Commun 5:5244

Showing the most recent 10 out of 80 publications