Columbia University Medical Center's (CUMC) CTSA and Irving Institute for Clinical and Translational Research (IICTR), using the expertise and commitment of faculty in 10 Key Resources have made outstanding progress toward the goal of transforming the culture of clinical and translational (C/T) research at CUMC. Examples include: novel projects using interdisciplinary approaches;a novel, 2-phase interdisciplinary pilot award program that has already captured several NIH grants;a Website for all service request that also has a faculty directory that facilitates collaborative research;5 hours of free consultation to more than 600 investigators leading to 33 NIH grants and 106 publications;collaboration among several CUMC regulatory groups that has significantly improved contracting, IRB time-to-approval, and ethics education/consultation services;successful launch of satellites research facilities in ICUs and EDs resulting in 50 new investigators conducting 30 new protocols;opening ofthe Columbia Community Partnership for Health center, one-half mile from CUMC, as a home for community-based organizations and communitybased participatory research;launching of a new Master's degree in POR, a novel one year certificate curriculum within existing T32 programs, and an outstanding KL2 program with 9 scholars already capturing independent funding;and transformation of the """"""""old"""""""" GCRC core laboratory into a campus-wide biomarkers core serving T l , T2 and T3 investigators. Throughout, our Tracking and Evaluation Group has provided critical assistance regarding future direction. Most importantly, we have validated the concept of the CTSA and are changing the culture of research at CUMC. In the next 4 years, with institutional support of nearly $4 million yearly, we will build upon this foundation and (1) Expand the resources and infrastructure that we have developed forT2 and T3 clinical researchers;(2) Capitalize on CUMC's outstanding Tl discovery research community by integrating existing resources and investigators even more closely into our CTSA. (3) Improve the health of our community by working with the NYPH ambulatory care network and community based organizations to develop platforms for corriparative effectiveness research.

Public Health Relevance

The Clinical and Translational Science Award (CTSA) allows Columbia University to support novel programs whose goal is to speed the translation of scientific discoveries made in the laboratory into new therapies. The CTSA will ensure that these new therapies are accepted by practicing physicians and community members so that we can begin to significantly improve the health of our community and nation.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Linked Training Award (TL1)
Project #
2TL1RR024158-06
Application #
8233597
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Talbot, Bernard
Project Start
2006-09-30
Project End
2016-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
6
Fiscal Year
2011
Total Cost
$179,776
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Marneweck, Michelle; Kuo, Hsing-Ching; Smorenburg, Ana R P et al. (2018) The Relationship Between Hand Function and Overlapping Motor Representations of the Hands in the Contralesional Hemisphere in Unilateral Spastic Cerebral Palsy. Neurorehabil Neural Repair 32:62-72
Boland, Mary Regina; Parhi, Pradipta; Gentine, Pierre et al. (2017) Climate Classification is an Important Factor in Assessing Quality-of-Care Across Hospitals. Sci Rep 7:4948
Kuo, Hsing-Ching; Ferre, Claudio L; Carmel, Jason B et al. (2017) Using diffusion tensor imaging to identify corticospinal tract projection patterns in children with unilateral spastic cerebral palsy. Dev Med Child Neurol 59:65-71
Friel, Kathleen M; Kuo, Hsing-Ching; Fuller, Jason et al. (2016) Skilled Bimanual Training Drives Motor Cortex Plasticity in Children With Unilateral Cerebral Palsy. Neurorehabil Neural Repair 30:834-44
Deng, Zhi-De; Lisanby, Sarah H; Peterchev, Angel V (2015) Effect of anatomical variability on electric field characteristics of electroconvulsive therapy and magnetic seizure therapy: a parametric modeling study. IEEE Trans Neural Syst Rehabil Eng 23:22-31
Harleton, Erin; Besana, Alessandra; Chandra, Parag et al. (2015) TASK-1 current is inhibited by phosphorylation during human and canine chronic atrial fibrillation. Am J Physiol Heart Circ Physiol 308:H126-34
Frederick, A L; Yano, H; Trifilieff, P et al. (2015) Evidence against dopamine D1/D2 receptor heteromers. Mol Psychiatry 20:1373-85
Sharp, Madeleine E; Caccappolo, Elise; Mejia-Santana, Helen et al. (2015) The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study. Mov Disord 30:278-83
Klitzman, Robert; Toynbee, Mark; Sauer, Mark V (2015) Controversies concerning mitochondrial replacement therapy. Fertil Steril 103:344-6
Fedorowicz, Maja A; de Vries-Schneider, Rosa L A; Rüb, Cornelia et al. (2014) Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy. EMBO Rep 15:86-93

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