The principal objective of the Clinical and Translational Education Program (CTEP) is to develop a pipeline of highly trained C/T researchers (Figure 1) to facilitate the transfer of clinical research - from bench to bedside - into clinical practice. As previously discussed at length, WMC and its partner institutions have a substantial pool of academically strong, diverse students who are potential candidates for our proposed clinical and translational science educational program. A broad didactic multi-disciplinary educational experience has been provided with a strong trans-institutional mentoring program to guide and support trainees as they learn the complexities of conducting research in a team environment. Since our CTSC is designed to promote translational research in a team-oriented environment, all team research members will be provided with the opportunity to obtain the necessary training to establish long-term C/T research careers. In sum, an integrated and flexible environment for research education has been created that is broad in scope, providing training careers in multidisciplinary team-based translational science at varying levels. I. BACKGROUND AND OVERVIEW Rigorous training of future investigators in the science and ethics of clinical and translational (C/T) research is essential to address the anticipated shortage of qualified clinical researchers, increase the odds of success and ultimately impact the quality of clinical care. It is well known that major advances will continue to come from scientists who are motivated by the intellectual challenges of disease-oriented research in their search for new biological discoveries. Evidence-based medicine depends on the results and interpretation of clinical investigations. It is imperative, therefore, that clinical and translational researchers are properly trained so that their research does not suffer from erroneous conclusions, wasted resources or flaws in clinical trial design, analysis and interpretation of data. To this end, a well-coordinated and integrated clinical and translational research training endeavor has been developed utilizing 1:he diverse trans-institutional faculty and other resources for teaching and mentoring. The members of the faculty are from Weill Cornell Medical and Graduate Schools, Memorial Sloan Kettering Cancer Center, Hospital for Special Surgery, the Hunter College School of Nursing, the Hunter College Gene Center (Research Center for Minority Institutions) and the extensive community outreach program coordinated through the Cornell University Cooperative Extension-NYC. As described in the various chapters of this grant and summarized in section XVI of this chapter, the trainees have access to many state-of-the-art facilities, an expanded clinical research center (PCIR), technical and support core facilities, and a large and diverse patient population from its partner hospitals, (see section XVI).

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Linked Training Award (TL1)
Project #
5TL1RR024998-05
Application #
8137831
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Filart, Rosemarie
Project Start
2007-09-17
Project End
2012-05-31
Budget Start
2011-06-01
Budget End
2012-05-31
Support Year
5
Fiscal Year
2011
Total Cost
$141,968
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
Olden, Megan; Wyka, Katarzyna; Cukor, Judith et al. (2017) Pilot Study of a Telehealth-Delivered Medication-Augmented Exposure Therapy Protocol for PTSD. J Nerv Ment Dis 205:154-160
Ng, Kenneth W; Torzilli, Peter A; Warren, Russell F et al. (2014) Characterization of a macroporous polyvinyl alcohol scaffold for the repair of focal articular cartilage defects. J Tissue Eng Regen Med 8:164-8
Yellen, Paige; Foster, David A (2014) Inhibition of fatty acid synthase induces pro-survival Akt and ERK signaling in K-Ras-driven cancer cells. Cancer Lett 353:258-63
Kleiman, David A; Beninato, Toni; Sultan, Samuel et al. (2014) Silencing of UCHL1 by CpG promoter hyper-methylation is associated with metastatic gastroenteropancreatic well-differentiated neuroendocrine (carcinoid) tumors. Ann Surg Oncol 21 Suppl 4:S672-9
Bourne, Jonathan W; Lippell, Jared M; Torzilli, Peter A (2014) Glycation cross-linking induced mechanical-enzymatic cleavage of microscale tendon fibers. Matrix Biol 34:179-84
Golas, Alyssa Reiffel; Perez, Justin L; Fullerton, Natalia et al. (2013) Vascular smooth muscle cell optimization of vasculogenesis within naturally derived, biodegradable, hybrid hydrogel scaffolds. Plast Reconstr Surg 132:952e-63e
Kleiman, David A; Sporn, Matthew J; Beninato, Toni et al. (2013) Early referral for 24-h esophageal pH monitoring may prevent unnecessary treatment with acid-reducing medications. Surg Endosc 27:1302-9
Kleiman, David A; Buitrago, Daniel; Crowley, Michael J et al. (2013) Thyroid stimulating hormone increases iodine uptake by thyroid cancer cells during BRAF silencing. J Surg Res 182:85-93
Stojadinovic, Olivera; Minkiewicz, Julia; Sawaya, Andrew et al. (2013) Deep tissue injury in development of pressure ulcers: a decrease of inflammasome activation and changes in human skin morphology in response to aging and mechanical load. PLoS One 8:e69223
Ng, Kenneth W; Wanivenhaus, Florian; Chen, Tony et al. (2013) Differential cross-linking and radio-protective effects of genipin on mature bovine and human patella tendons. Cell Tissue Bank 14:21-32

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