At the University of Kentucky (UK), we have established the Center for Clinical and Translational Science (CCTS) as a home for clinical and translational research. UK is located in Lexington, on the western edge of mid-Appalachia, one of the poorest areas of the country, where there are unprecedented disparities in disease and mortality. Many of these disparities stem from risky behaviors, such as smoking, drug abuse, and obesity. In this proposal, our overarching goal is to transform the pace, effectiveness, and quality of translational research at UK which will result in better health for the people of mid-Appalachia. Scientific discovery offers the potential for improved care, with community-based research offering a faster impact on health through a better dissemination of optimal medical care. However, scientific discoveries often do not reach the community due to the many difficulties with navigating the complex process of clinical and translational research. In this application, we will capitalize on our strengths in education, basic and clinical sciences, as well as our outstanding programs in practice- and community- based participatory research. These efforts will result in scientific discovery that will impact the health of the Appalachian rural community in the near term, and prime the pipeline for the future. To accomplish these goals, UK will form a collaboration with Marshall University, which is 2 hr away in Huntington, WV. In addition, we will form an Appalachian Translational Reseach Network involving not only Marshall, but also the CTSAs at the Ohio State University, University of Cinncinati, Morehead University, and Pikeville School of Osteopathic Medicine. This network will be especially important in the further development of our strong programs in community based participatory research. To help integrate our efforts, we have developed an innovative group of faculty CATalysts, who will build collaborative team science programs backed by generous pilot funding that will target novel ideas at all levels of science. New CCTS programs in """"""""Drug Development"""""""", 'Novel Methodologies"""""""", and """"""""Risk-Related Behavior Research"""""""" will capitalize on our strengths, engage investigators with diverse areas of expertise, and will more quickly impact the health of the Appalachian community. We have recently recruited a new leader in Biomedical Informatics and have invested heavily in this program, which will greatly improve our ability to transform data into knowledge throughout the CCTS. Through these initiatives, UK will fulfill its mandate as Kentucky's flagship university to improve the health of Central Appalachia, and thereby add unique value to improvements in the health of the nation.

Public Health Relevance

The CCTS at UK has developed well-integrated relationships with University programs in Central Appalachia and with rural health programs. We routinely apply a foundation principal of community based participatory research, where the lay community identifies the research issues and co-develops solutions. This proposal seeks to make research more relevant by breaking down barriers to research translation and greatly improving the pace by which science discoveries drive improvements in health in Kentucky and the nation.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Training Award (TL1)
Project #
5TL1TR000115-04
Application #
8637113
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Brazhnik, Olga
Project Start
2011-06-01
Project End
2016-02-29
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
4
Fiscal Year
2014
Total Cost
$152,732
Indirect Cost
$9,272
Name
University of Kentucky
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Stromp, Tori A; Spear, Tyler J; Holtkamp, Rebecca M et al. (2018) Quantitative Gadolinium-Free Cardiac Fibrosis Imaging in End Stage Renal Disease Patients Reveals A Longitudinal Correlation with Structural and Functional Decline. Sci Rep 8:16972
Kline, Paul W; Burnham, Jeremy; Yonz, Michael et al. (2018) Hip external rotation strength predicts hop performance after anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 26:1137-1144
Gold, Brian T; Brown, Christopher A; Hakun, Jonathan G et al. (2017) Clinically silent Alzheimer's and vascular pathologies influence brain networks supporting executive function in healthy older adults. Neurobiol Aging 58:102-111
Reynolds, Leryn J; Dickens, Brett J; Green, Benjamin B et al. (2017) Using neonatal skin to study the developmental programming of aging. Exp Gerontol 94:93-98
Brown, Christopher A; Johnson, Nathan F; Anderson-Mooney, Amelia J et al. (2017) Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease. Neuroimage Clin 13:106-115
Li, Juan; Broster, Lucas S; Jicha, Gregory A et al. (2017) A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging. Alzheimers Res Ther 9:3
Bolin, B Levi; Lile, Joshua A; Marks, Katherine R et al. (2016) Buspirone reduces sexual risk-taking intent but not cocaine self-administration. Exp Clin Psychopharmacol 24:162-73
Klimyte, Edita M; Smith, Stacy E; Oreste, Pasqua et al. (2016) Inhibition of Human Metapneumovirus Binding to Heparan Sulfate Blocks Infection in Human Lung Cells and Airway Tissues. J Virol 90:9237-50
Ickes, Melinda J; Butler, Karen; Rayens, Mary Kay et al. (2016) Recall and Believability of the Tips From Former Smokers Campaign Among University Students. Am J Health Educ 47:324-331
Marks, Katherine R; Lile, Joshua A; Stoops, William W et al. (2016) Separate and Combined Effects of Naltrexone and Extended-Release Alprazolam on the Reinforcing, Subject-Rated, and Cardiovascular Effects of Methamphetamine. J Clin Psychopharmacol 36:213-21

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