This application is in response to the RFA-AA-11-006 to provide support for the continuation of our consortium Integrative Neuroscience Initiative on Alcoholism: Stress, Anxiety and Excessive Drinking (a.k.a. INIAstress). Since its inception in 2002, INIAstress has had the primary goal of coordinating and facilitating translational, multidisciplinary and integrative research aimed at elucidating genetic and environmental influences on brain mechanisms that mediate excessive alcohol (ethanol) consumption, the response to stress, and the reciprocal relationship between excessive drinking, the physiological state of stress, and the subjective state of anxiety. Through this characterization we have helped to define factors that contribute to an individual's risk for the development of alcoholism, revealed underlying mechanisms and conditions that promote excessive and harmful drinking, and forged progress towards discovering novel, more effective, and tailored treatment strategies. In this renewal, we continue our cross-species approach and have further refined our INIAstress projects and cores to inform us about unique adaptations in brain circuitry following chronic intermittent ethanol exposure (ethanol-allostasis) that impact subsequent interaction of stress and ethanol to promote further excessive drinking. Collectively, these collaborative studies directly integrate behavioral, endocrine, neural and genetic data from animal models to humans within a scope of expertise and thematic inquiry that would not be possible using more traditional grant mechanisms (ROs or P50).

Public Health Relevance

Stress and anxiety have long been implicated in the development of harmful drinking, its escalation to alcoholism and relapse to drinking following a period of abstinence. The INIAstress consortium uses a state-of-the-art translational approach (mice, monkeys and humans) to understand the complex interaction of stress and excessive drinking and identify novel, effective and tailored treatment strategies for alcoholism.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1-DD (51))
Program Officer
Noronha, Antonio
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Oregon Health and Science University
Other Basic Sciences
Schools of Medicine
United States
Zip Code
Ford, Matthew M; Nickel, Jeffrey D; Kaufman, Moriah N et al. (2015) Null mutation of 5?-reductase type I gene alters ethanol consumption patterns in a sex-dependent manner. Behav Genet 45:341-53
Piza-Palma, Carlos; Barfield, Elizabeth T; Brown, Jadeda A et al. (2014) Oral self-administration of EtOH: sex-dependent modulation by running wheel access in C57BL/6J mice. Alcohol Clin Exp Res 38:2387-95
Colombo, Giancarlo; Maccioni, Paola; Acciaro, Carla et al. (2014) Binge drinking in alcohol-preferring sP rats at the end of the nocturnal period. Alcohol 48:301-11
Ford, Matthew M (2014) Applications of schedule-induced polydipsia in rodents for the study of an excessive ethanol intake phenotype. Alcohol 48:265-76
Messaoudi, Ilhem; Pasala, Sumana; Grant, Kathleen (2014) Could moderate alcohol intake be recommended to improve vaccine responses? Expert Rev Vaccines 13:817-9
Porcu, Patrizia; Morrow, A Leslie (2014) Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies. Psychopharmacology (Berl) 231:3257-72
Nesic, Jelena; Duka, Theodora (2014) Effects of stress and dietary tryptophan enhancement on craving for alcohol in binge and non-binge heavy drinkers. Behav Pharmacol 25:503-17
Asquith, Mark; Pasala, Sumana; Engelmann, Flora et al. (2014) Chronic ethanol consumption modulates growth factor release, mucosal cytokine production, and microRNA expression in nonhuman primates. Alcohol Clin Exp Res 38:980-93
Rosenwasser, Alan M; Fixaris, Michael C (2013) Chronobiology of alcohol: studies in C57BL/6J and DBA/2J inbred mice. Physiol Behav 110-111:140-7
Ford, Matthew M; Davis, Natalie L; McCracken, Aubrey D et al. (2013) Contribution of NMDA glutamate and nicotinic acetylcholine receptor mechanisms in the discrimination of ethanol-nicotine mixtures. Behav Pharmacol :

Showing the most recent 10 out of 49 publications