This application is in response to the RFA-AA-11-006 to provide support for the continuation of our consortium Integrative Neuroscience Initiative on Alcoholism: Stress, Anxiety and Excessive Drinking (a.k.a. INIAstress). Since its inception in 2002, INIAstress has had the primary goal of coordinating and facilitating translational, multidisciplinary and integrative research aimed at elucidating genetic and environmental influences on brain mechanisms that mediate excessive alcohol (ethanol) consumption, the response to stress, and the reciprocal relationship between excessive drinking, the physiological state of stress, and the subjective state of anxiety. Through this characterization we have helped to define factors that contribute to an individual's risk for the development of alcoholism, revealed underlying mechanisms and conditions that promote excessive and harmful drinking, and forged progress towards discovering novel, more effective, and tailored treatment strategies. In this renewal, we continue our cross-species approach and have further refined our INIAstress projects and cores to inform us about unique adaptations in brain circuitry following chronic intermittent ethanol exposure (ethanol-allostasis) that impact subsequent interaction of stress and ethanol to promote further excessive drinking. Collectively, these collaborative studies directly integrate behavioral, endocrine, neural and genetic data from animal models to humans within a scope of expertise and thematic inquiry that would not be possible using more traditional grant mechanisms (ROs or P50).

Public Health Relevance

Stress and anxiety have long been implicated in the development of harmful drinking, its escalation to alcoholism and relapse to drinking following a period of abstinence. The INIAstress consortium uses a state-of-the-art translational approach (mice, monkeys and humans) to understand the complex interaction of stress and excessive drinking and identify novel, effective and tailored treatment strategies for alcoholism.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AA013641-13
Application #
8423713
Study Section
Special Emphasis Panel (ZAA1-DD (51))
Program Officer
Noronha, Antonio
Project Start
2002-02-01
Project End
2017-01-31
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
13
Fiscal Year
2013
Total Cost
$483,977
Indirect Cost
$150,140
Name
Oregon Health and Science University
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Ketchesin, Kyle D; Stinnett, Gwen S; Seasholtz, Audrey F (2016) Binge Drinking Decreases Corticotropin-Releasing Factor-Binding Protein Expression in the Medial Prefrontal Cortex of Mice. Alcohol Clin Exp Res 40:1641-50
Siciliano, Cody A; Calipari, Erin S; Yorgason, Jordan T et al. (2016) Chronic ethanol self-administration in macaques shifts dopamine feedback inhibition to predominantly D2 receptors in nucleus accumbens core. Drug Alcohol Depend 158:159-63
Porcu, P; Barron, A M; Frye, C A et al. (2016) Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research. J Neuroendocrinol 28:12351
Colombo, Giancarlo; Lobina, Carla; Maccioni, Paola et al. (2015) Anxiety-like behaviors at the end of the nocturnal period in sP rats with a "history" of unpredictable, limited access to alcohol. Alcohol 49:707-12
Cui, Changhai; Noronha, Antonio; Warren, Kenneth R et al. (2015) Brain pathways to recovery from alcohol dependence. Alcohol 49:435-52
Yang, Hongyu; Spence, Jeffrey S; Briggs, Richard W et al. (2015) Interaction between early life stress and alcohol dependence on neural stress reactivity. Addict Biol 20:523-33
Ford, Matthew M; Nickel, Jeffrey D; Kaufman, Moriah N et al. (2015) Null mutation of 5α-reductase type I gene alters ethanol consumption patterns in a sex-dependent manner. Behav Genet 45:341-53
Maccioni, Paola; Lorrai, Irene; Marras, Maria Francesca et al. (2015) Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats. Psychopharmacology (Berl) 232:3585-95
Ketchesin, Kyle D; Seasholtz, Audrey F (2015) Novel Roles for CRF-Binding Protein and CRF Receptor 2 in Binge Drinking. Alcohol Clin Exp Res 39:2296-8
Nesic, Jelena; Duka, Theodora (2014) Effects of stress and dietary tryptophan enhancement on craving for alcohol in binge and non-binge heavy drinkers. Behav Pharmacol 25:503-17

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