This competing continuation proposal for Years 29-34 of the Health and Retirement Study (HRS) cooperative agreement is in response to NIA RFA #AG-18-005. The primary aim of the HRS is to design, collect and distribute longitudinal multi-disciplinary data to support research on aging and the health and well- being of the older population. This proposal seeks to collect three additional waves of panel data, continue collection of venous blood specimens, implement the next scheduled refreshment by adding the first Gen-X cohort in 2022, continue to conduct off-year mail surveys, and implement cost-saving innovations, including an internet mode for Core data collection. It will continue the same expanded minority oversample design for the Gen-X cohort as was implemented in 2010 and 2016 for the baby boom cohorts in which half the sample consists of traditionally underrepresented minorities. The new Gen-X cohort will be fully integrated into the HRS design, including collection of biomarkers, DNA, and linkage consents to Social Security and other records as appropriate. This parent project will provide sample, data, and coordinate fully with the separate proposal to repeat the Harmonized Cognitive Assessment Protocol dementia study. HRS provides a uniquely rich, nationally representative longitudinal dataset for the community of scientific and policy researchers who study the health and demography of aging. It provides a research data base that can simultaneously support cross-sectional descriptions of the U.S. population age 50+, longitudinal studies of a given cohort over a substantial period of time and research on cross-cohort trends. The HRS project creates a data system extending beyond the core survey data. One component of this extended data system consists of linkages to administrative data, including Social Security earnings and benefit records, Medicare utilization and diagnostic records, including Minimum Data Set and Medicaid records, employer pension records, Veterans Health Administration data and the National Death Index. We plan to expand access to these secure data through secure enclaves. Another component is genome-wide genotyping data from consenting respondents distributed through dbGaP and a new repository of blood samples including cryopreserved cells. HRS provides public use data designed to allow the full power and creativity of America's scientific community to address the challenges of an aging population. HRS is making a significant impact on research on aging through investigator-initiated research which uses the HRS as an input without charge to researchers or granting agencies. Over 2,000 peer-reviewed journal publications have appeared, nearly 1,000 in the past six years. HRS also supports training of new scientists as over 400 doctoral dissertations have used HRS data.

Public Health Relevance

This proposal seeks continuation of the Health and Retirement Study core data collection for three more waves, including the introduction of a new younger cohort in 2022 to refresh the sample following the steady state sampling design. It will build the repository of biosamples, maintain the expanded representation of minorities, and further expand data access to maintain the study as the premier source of data on public health of the older population. Cost savings will be achieved through innovative methods.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Patmios, Georgeanne E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Organized Research Units
Ann Arbor
United States
Zip Code
Reus-Pons, Matias; Mulder, Clara H; Kibele, Eva U B et al. (2018) Differences in the health transition patterns of migrants and non-migrants aged 50 and older in southern and western Europe (2004-2015). BMC Med 16:57
Robinette, Jennifer W; Charles, Susan T; Gruenewald, Tara L (2018) Neighborhood cohesion, neighborhood disorder, and cardiometabolic risk. Soc Sci Med 198:70-76
Kemp, Blakelee R; Ferraro, Kenneth F; Morton, Patricia M et al. (2018) Early Origins of Adult Cancer Risk Among Men and Women: Influence of Childhood Misfortune? J Aging Health 30:140-163
Wei, Melissa Y; Kabeto, Mohammed U; Langa, Kenneth M et al. (2018) Multimorbidity and Physical and Cognitive Function: Performance of a New Multimorbidity-Weighted Index. J Gerontol A Biol Sci Med Sci 73:225-232
Crittenden, Crista N; Murphy, Michael L M; Cohen, Sheldon (2018) Social integration and age-related decline in lung function. Health Psychol 37:472-480
Chao, Yi-Sheng; Wu, Hsing-Chien; Wu, Chao-Jung et al. (2018) Index or illusion: The case of frailty indices in the Health and Retirement Study. PLoS One 13:e0197859
Henseke, Golo (2018) Good jobs, good pay, better health? The effects of job quality on health among older European workers. Eur J Health Econ 19:59-73
GBD 2017 DALYs and HALE Collaborators (2018) Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392:1859-1922
Stephan, Yannick; Sutin, Angelina R; Bayard, Sophie et al. (2018) Personality and sleep quality: Evidence from four prospective studies. Health Psychol 37:271-281
McKee, Michael M; Choi, HwaJung; Wilson, Shelby et al. (2018) Determinants of Hearing Aid Use Among Older Americans With Hearing Loss. Gerontologist :

Showing the most recent 10 out of 852 publications