Osteoarthritis (OA) is the most common form of arthritis and remains one of the few chronic diseases of aging for which there is little if any effective treatment and few preventive strategies. Symptomatic knee osteoarthritis affects 12% of elders and despite medical advances, remains, for many affected, a major source of pain and function limitation. The MOST study is the first large scale observational study to focus on persons with or at high risk of knee osteoarthritis. The central goal of MOST is to identify modifiable risk factors. To accomplish this, we recruited and have followed 3026 persons who either had knee osteoarthritis at baseline or were at high risk of developing disease because they had one or more disease risk factors. We are proposing a renewal of MOST. In continuing to follow this unique cohort, we will address a series of new questions representing three investigative themes: mechanical risk factors, causes of knee symptoms and long term disease trajectory. The focus on risk factors which affect knees on the basis of loading reflects the view of MOST investigators that OA is a mechanically driven disease. Mechanical risk factors are likely to be both strongly associated with disease risk and modifiable. Pain is the cardinal symptom of OA and the main cause of its clinical and public health impact. An investigation of pain sensitivity seeks to better understand the neurological mechanisms that sustain or magnify OA symptoms. Another symptom associated with knee OA is knee buckling, whose frequency and impact has only recently been described and whose association with falls and fractures in older adults is unknown. Lastly, we will take advantage of two grant cycles of comprehensive information on functional loss and repeated MRI's to address the long term trajectory of this chronic disease. In this renewal of the MOST study we will re-examine a group of persons who already have disease or are at high risk of getting it, to evaluate the risk factors for disease. Those factors that prove to be related to disease development or progression could then be targeted for risk factor modification offering unique opportunities for disease prevention. Risk factors to be studied include many which are practical to modify, including strength, ways of walking, and balance. Also, MOST will provide the best understanding yet of the relation between changes in knee structures and their effects on pain and function, providing structural targets for treatment.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AG018820-13
Application #
8599739
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (M2))
Program Officer
Joseph, Lyndon
Project Start
2001-01-01
Project End
2014-12-31
Budget Start
2014-01-15
Budget End
2014-12-31
Support Year
13
Fiscal Year
2014
Total Cost
$656,224
Indirect Cost
$252,394
Name
Boston University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Misra, Devyani; Felson, David T; Silliman, Rebecca A et al. (2015) Knee osteoarthritis and frailty: findings from the Multicenter Osteoarthritis Study and Osteoarthritis Initiative. J Gerontol A Biol Sci Med Sci 70:339-44
Misra, D; Guermazi, A; Sieren, J P et al. (2015) CT imaging for evaluation of calcium crystal deposition in the knee: initial experience from the Multicenter Osteoarthritis (MOST) study. Osteoarthritis Cartilage 23:244-8
Niu, Jingbo; Nevitt, Michael; McCulloch, Charles et al. (2014) Comparing the functional impact of knee replacements in two cohorts. BMC Musculoskelet Disord 15:145
Boissonneault, A; Lynch, J A; Wise, B L et al. (2014) Association of hip and pelvic geometry with tibiofemoral osteoarthritis: multicenter osteoarthritis study (MOST). Osteoarthritis Cartilage 22:1129-35
Chaganti, R K; Tolstykh, I; Javaid, M K et al. (2014) High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis. Osteoarthritis Cartilage 22:190-6
Glass, N; Segal, N A; Sluka, K A et al. (2014) Examining sex differences in knee pain: the multicenter osteoarthritis study. Osteoarthritis Cartilage 22:1100-6
Crema, M D; Nevitt, M C; Guermazi, A et al. (2014) Progression of cartilage damage and meniscal pathology over 30 months is associated with an increase in radiographic tibiofemoral joint space narrowing in persons with knee OA--the MOST study. Osteoarthritis Cartilage 22:1743-7
Felson, David T; Hodgson, Richard (2014) Identifying and treating preclinical and early osteoarthritis. Rheum Dis Clin North Am 40:699-710
White, Daniel K; Tudor-Locke, Catrine; Zhang, Yuqing et al. (2014) Daily walking and the risk of incident functional limitation in knee osteoarthritis: an observational study. Arthritis Care Res (Hoboken) 66:1328-36
Maxwell, Jessica L; Felson, David T; Niu, Jingbo et al. (2014) Does clinically important change in function after knee replacement guarantee good absolute function? The multicenter osteoarthritis study. J Rheumatol 41:60-4

Showing the most recent 10 out of 80 publications