Since 1993, the Washington Metropolitan WIHS (WMW) Consortium has enrolled and retained a representative community cohort of HIV-infected and uninfected women with the purpose of supporting NIAID in understanding the current epidemiology of HIV, risk behaviors, disease progression, treatment uptake and outcomes, and related co-morbidities. The early cohort of infected women is aging, and the effects of age and menopausal status on disease outcomes and co-morbidities is yet to be elucidated. The WMW has joined with centers around the country and with sites across metropolitan Washington, DC to address these issues. This is particularly pertinent as Washington, DC has the highest prevalence of HIV of any urban center in the U.S. and the WMW has enrolled and retained a cohort that represents women both ethnically and psychosocially. The WMW has successfully participated in all elements of the WIHS protocol and has actively supported the infrastructure of the national WIHS. WMW investigators have participated in all of the major WIHS scientific initiatives. Additionally, with its rich data baseand local and national specimen repository, the WMW has supported local and national initiatives designed to understand the pathophysiology underlying co-morbidities. The WMW proposes to continue this work and to expand its research portfolio by continuing its strong collaborative relationship with the national WIHS in the area of protocol development, implementation, sub study participation, and identification of new initiatives. Additionally, for the next cycle of funing we have proposed new initiatives that include a telephone-based intervention for depression that will positively impact adherence and health behaviors with the goal of reducing community viral load. This intervention can easily be implemented in the larger DC community. We are expanding our local initiatives on HIV and HCV associated liver disease by engaging a team of researchers in exploring the host response, epigenetic factors, and protein glycosylation in liver disease and cancer. We will also continue and expand our investigations in organ specific morbidities associated with long-term survival in an aging population with the goal of reducing or preventing morbidity in the areas of vascular health, neurocognitive decline, and the vaginal immunologic response in aging. We will accomplish this by engaging with national and local investigators with proven expertise in these areas to further leverage the NIH investment in this important cohort of women. This will allow us to better define the status of women with HIV and bring to fruition the goals of an AIDS free generation and effective and sustainable treatment for those already infected.
Washington, DC has the highest prevalence of HIV of any urban center in the U.S. The Washington Metropolitan Women's Interagency HIV Study (WMW), by recruiting and retaining for over 18 years a highly representative community-based cohort of women from this region, is well-positioned to impact the health of this community. By understanding the factors that place women at risk of HIV, the impediments and barriers to effective treatment and the consequences of aging with treated HIV, the WMW will advance the goals of the NIH and the public health community in impacting this important and costly disease both locally and nationally.
|Scherzer, Rebecca; Bacchetti, Peter; Messerlian, Geralyn et al. (2015) Impact of CD4+ lymphocytes and HIV infection on Anti-Müllerian Hormone levels in a large cohort of HIV-infected and HIV-uninfected women. Am J Reprod Immunol 73:273-84|
|Landay, Alan; Golub, Elizabeth T; Desai, Seema et al. (2014) HIV RNA levels in plasma and cervical-vaginal lavage fluid in elite controllers and HAART recipients. AIDS 28:739-43|
|Mata, Mariana M; Iwema, Joyce R; Dell, Shanna et al. (2014) Comparison of antibodies that mediate HIV type 1 gp120 antibody-dependent cell-mediated cytotoxicity in asymptomatic HIV type 1-positive men and women. AIDS Res Hum Retroviruses 30:50-7|
|Aka, Peter V; Kuniholm, Mark H; Pfeiffer, Ruth M et al. (2014) Association of the IFNL4-?G Allele With Impaired Spontaneous Clearance of Hepatitis C Virus. J Infect Dis 209:350-4|
|Pyra, Maria; Weber, Kathleen; Wilson, Tracey E et al. (2014) Sexual minority status and violence among HIV infected and at-risk women. J Gen Intern Med 29:1131-8|
|Torre 3rd, Peter; Hoffman, Howard J; Springer, Gayle et al. (2014) Cochlear function among HIV-seropositive and HIV-seronegative men and women. Ear Hear 35:56-62|
|Massad, L Stewart; Pierce, Christopher B; Minkoff, Howard et al. (2014) Long-term cumulative incidence of cervical intraepithelial neoplasia grade 3 or worse after abnormal cytology: impact of HIV infection. Int J Cancer 134:1854-61|
|Stewart Massad, L; D'Souza, Gypsyamber; Darragh, Teresa M et al. (2014) Accuracy of colposcopy in HIV seropositive and seronegative women with abnormal Pap tests. Gynecol Oncol 135:481-6|
|Zhang, Lulu; She, Xiaodong; Merenstein, Daniel et al. (2014) Fluconazole Resistance Patterns in Candida Species that Colonize Women with HIV Infection. Curr Ther Res Clin Exp 76:84-9|
|Sirotin, Nicole; Hoover, Donald R; Shi, Qiuhu et al. (2014) Food insecurity with hunger is associated with obesity among HIV-infected and at risk women in Bronx, NY. PLoS One 9:e105957|
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