The UCLA site has a 25-year history of outstanding performance as a clinical site of the MACS, maintaining current status information on over 88.5% of the 1637 participants. The empathetic, committed staff, most of whom have been with the study for more than 15 years (and some for 25 years), has been cited by participants as a key to their continued commitment to the UCLA MACS. State-of-the-art laboratory procedures have been implemented, and quality assurance procedures put in place. The Center has recruited an outstanding group of UCLA investigators to participate in the MACS, and to assume leadership roles in various scientific areas, taking leadership for 52 research publications since 2003 and contributing to 60 other MACS scientific papers. The objectives of the UCLA MACS Clinical Center are to: 1) Maintain the cohorts of men recruited in 1984-5 and the men more recently recruited in 2002-3 (primarily Hispanic-Americans and African-Americans); 2) Collect specific behavioral, clinical and psychosocial data, and laboratory specimens from the men; 3) Process laboratory specimens for the local and national specimen repositories of serum, plasma, and cells and to perform flow cytometry and serologic measurements on these samples from Los Angeles participants; 4) Maintain the local repository for use by local investigators; 5) Contribute to ongoing and future studies of cardiovascular complications, renal function, liver diseases, neurocognitive impairment, malignancies, aging, and genomic characteristics of MACS participants; 6) Contribute scientific leadership to the MACS through leadership of several MACS working groups (Core Laboratory, Malignancies/Pathology, Neuropsychology), organization of quality control procedures, leadership in key MACS papers and participation in others, and active participation in the bi-monthly conference calls and meetings of the MACS; 7) Recruit both experienced and new investigators who bring new scientific insights and skills that will enhance the quality and breadth of science in the MACS.

Public Health Relevance

The MACS incorporates a large database of information and biologic specimens collected every six months from 6,972 men followed since 1985-5 (primarily European-American) and 2002-3 (primarily Latino and African-American), and allows continuing observation of the 3243 survivors. Thus, the MACS provides an irreplaceable resource for continued study of the natural history of treated and untreated HIV infection and AIDS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI035040-21
Application #
8449568
Study Section
Special Emphasis Panel (ZAI1-EB-A (J1))
Program Officer
Roe, Joanad'Arc C
Project Start
1993-04-01
Project End
2014-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
21
Fiscal Year
2013
Total Cost
$4,237,269
Indirect Cost
$1,008,514
Name
University of California Los Angeles
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Kelly, Sean G; Plankey, Michael; Post, Wendy S et al. (2016) Associations between Tobacco, Alcohol, and Drug Use with Coronary Artery Plaque among HIV-Infected and Uninfected Men in the Multicenter AIDS Cohort Study. PLoS One 11:e0147822
Peckham-Gregory, Erin C; Thapa, Dharma R; Martinson, Jeremy et al. (2016) MicroRNA-related polymorphisms and non-Hodgkin lymphoma susceptibility in the Multicenter AIDS Cohort Study. Cancer Epidemiol 45:47-57
Okafor, Chukwuemeka N; Cook, Robert L; Chen, Xinguang et al. (2016) Trajectories of Marijuana Use among HIV-seropositive and HIV-seronegative MSM in the Multicenter AIDS Cohort Study (MACS), 1984-2013. AIDS Behav :
Zhang, Long; Tin, Adrienne; Brown, Todd T et al. (2016) Vitamin D Deficiency and Metabolism in HIV-Infected and HIV-Uninfected Men in the Multicenter AIDS Cohort Study. AIDS Res Hum Retroviruses :
Althoff, Keri N; Rebeiro, Peter F; Hanna, David B et al. (2016) A picture is worth a thousand words: maps of HIV indicators to inform research, programs, and policy from NA-ACCORD and CCASAnet clinical cohorts. J Int AIDS Soc 19:20707
Erlandson, Kristine M; Li, Xiuhong; Abraham, Alison G et al. (2016) Long-term impact of HIV wasting on physical function. AIDS 30:445-54
Lake, Jordan E; Popov, Mikhail; Post, Wendy S et al. (2016) Visceral fat is associated with brain structure independent of human immunodeficiency virus infection status. J Neurovirol :
McKay, Heather S; Bream, Jay H; Margolick, Joseph B et al. (2016) Host factors associated with serologic inflammatory markers assessed using multiplex assays. Cytokine 85:71-9
Klein, Marina B; Althoff, Keri N; Jing, Yuezhou et al. (2016) Risk of End-Stage Liver Disease in HIV-Viral Hepatitis Coinfected Persons in North America From the Early to Modern Antiretroviral Therapy Eras. Clin Infect Dis 63:1160-1167
Palella Jr, Frank J; McKibben, Rebeccah; Post, Wendy S et al. (2016) Anatomic Fat Depots and Coronary Plaque Among Human Immunodeficiency Virus-Infected and Uninfected Men in the Multicenter AIDS Cohort Study. Open Forum Infect Dis 3:ofw098

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