The University of Pittsburgh Multicenter AIDS Cohort Study (Pitt MACS) Clinical Research Site (CRS) was established in 1983 by Dr. C. Rinaldo, PI, as one of 4 MACS CRS as a prospective cohort study of the natural history of HIV infection and the impact of effective combination antiretroviral therapies (cART) in men who have sex with men (MSM). We will continue to combine genetic, virologic, immunologic and psychosocial approaches and utilize the specimen cryorepository for long-term characterization of Pitt MACS participants. Along with our new satellite clinic site at The Ohio State University (OSU) led by Dr. S. Koletar, we will continue follow-up of the cohort with a dynamic enrollment to enable further elucidation of the biology and response to HIV infection, and distinguishing the effects of age, HIV, evolving cART regimens, genetics, co- infections and behavior use on clinical outcomes and causally-associated biomarkers. This is a transition to a rolling cohort design to replace existing cohort members who die or otherwise are permanently lost to follow-up. The Pitt MACS scientific agenda focuses on clinical epidemiology, pathogenesis, psychosocial factors, and development of novel methods for the study of HIV disease. The Pitt MACS is ideally positioned to address these issues because of long-term standardized follow-up, an extensive repository and an appropriate control group of HIV-uninfected MSM with similar lifestyles, behaviors, and demographics. The Pitt MACS contributes strength and innovation in three areas: (a) studies of viral genomics and host immunopathogenesis including HHV-8/KSHV and HCV coinfections and regulation by host microRNAs, (b) in depth analysis of effects of HIV infection in the brain and lungs including microbiome analysis, and (c) studies of syndemics and resiliencies in aging MSM including effects on depression, substance use and sexual behavior. The Pitt MACS CRS will continue to contribute via the MACS Executive Committee and Working Groups with expertise in all aspects of HIV infection to successfully address our 7 scientific aims that are identical to those in Part A. The Pitt MACS will continue to characterize the long-term, natural and treated history of HIV infection in MSM, provide insight into the clinical epidemiology of HIV, and further our understanding of predictors of disease among HIV positive MSM.

Public Health Relevance

The scientific leadership and methods implemented by the Pitt MACS will enable the MACS to answer important questions relevant to treated HIV-infected MSM, the group with the highest HIV incidence in the US, and questions about the interaction of HIV and aging, important as the HIV-infected population shifts into older ages. The proposed research will provide information for development and administration of new interventions for HIV, as well as for the prevention of AIDS-defining and non-AIDS defining outcomes.

Agency
National Institute of Health (NIH)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01AI035041-22
Application #
8699457
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Roe, Joanad'Arc C
Project Start
Project End
Budget Start
Budget End
Support Year
22
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Public Health
DUNS #
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Zaccard, Colleen R; Watkins, Simon C; Kalinski, Pawel et al. (2015) CD40L induces functional tunneling nanotube networks exclusively in dendritic cells programmed by mediators of type 1 immunity. J Immunol 194:1047-56
Hart, Trevor A; Mustanski, Brian; Ryan, Daniel T et al. (2015) Depression and sexual dysfunction among HIV-positive and HIV-negative men who have sex with men: mediation by use of antidepressants and recreational stimulants. Arch Sex Behav 44:399-409
Becker, James T; Martinson, Jeremy J; Penugonda, Sudhir et al. (2015) No association between Apo?4 alleles, HIV infection, age, neuropsychological outcome, or death. J Neurovirol 21:24-31
Viswanathan, Shilpa; Detels, Roger; Mehta, Shruti H et al. (2015) Level of adherence and HIV RNA suppression in the current era of highly active antiretroviral therapy (HAART). AIDS Behav 19:601-11
Becker, James T; Kingsley, Lawrence A; Molsberry, Samantha et al. (2015) Cohort Profile: Recruitment cohorts in the neuropsychological substudy of the Multicenter AIDS Cohort Study. Int J Epidemiol 44:1506-16
Patil, Susheel P; Brown, Todd T; Jacobson, Lisa P et al. (2014) Sleep disordered breathing, fatigue, and sleepiness in HIV-infected and -uninfected men. PLoS One 9:e99258
Hensler, Heather R; Tomaszewski, Monica J; Rappocciolo, Giovanna et al. (2014) Human herpesvirus 8 glycoprotein B binds the entry receptor DC-SIGN. Virus Res 190:97-103
Zaccard, Colleen R; Watkins, Simon C; Ayyavoo, Velpandi et al. (2014) HIV's ticket to ride: Cytotoxic T-lymphocyte-activated dendritic cells exploited for virus intercellular transfer. AIDS Res Hum Retroviruses 30:1023-4
Price, Jennifer C; Seaberg, Eric C; Latanich, Rachel et al. (2014) Risk factors for fatty liver in the Multicenter AIDS Cohort Study. Am J Gastroenterol 109:695-704
Brener, Michael; Ketlogetswe, Kerunne; Budoff, Matthew et al. (2014) Epicardial fat is associated with duration of antiretroviral therapy and coronary atherosclerosis. AIDS 28:1635-44

Showing the most recent 10 out of 345 publications