The Women's Interagency HIV Study (WINS) is a large, comprehensive cohort study designed to investigate a spectrum of questions relating to the pathogenesis and natural history of HIV infection among women in the era of highly active antiretroviral therapy. The purpose of this application is to extend support of the WIHS Data Management and Analysis Center (WDMAC) that will continue to provide leadership in contributing epidemiological and statistical expertise to the WIHS research agenda, provide a stable and efficient data management system, and provide coordination of study protocols and WIHS investigator initiatives to enhance the quality and validity of the data and the scientific research in the WIHS.
The specific aims of WDMAC are: (1) To provide leadership in the design, analysis, and presentation of WIHS study data and to develop novel statistical and epidemiologic methodology applicable to the scientific research initiatives of the WIHS;(2) To establish and implement methods to coordinate research initiatives and scientific presentations, to facilitate communication among WIHS and external investigators, to orchestrate revisions of study protocols and forms, and to produce study-wide profiles of cohort characteristics (WIHS Dossier), the study database and ongoing research initiatives (WDMAC Report), and scientific publications (WIHS Archives);(3) To establish, implement, and maintain a web-based data management system encompassing data entry, transmission, documentation, editing, storage, summarization, and dissemination. Components of this aim include establishing a system for tracking the storage and transfer of biological specimens at national repositories, producing annual public data sets, and conducting training in methods that facilitates the appropriate use of study data for local research;(4) To implement a quality assurance program in partnership with the clinical sites that integrates expertise in data management, study coordination, statistical methodology, and scientific disciplines. This program will monitor study-wide quality and promote adherence and training for standardized data collection and management programs. As both a scientific partner and center for operations, this project serves to increase the breadth of initiatives that can be pursued, and the depth to which research questions are pursued, within WIHS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01AI042590-12S1
Application #
7922851
Study Section
Special Emphasis Panel (ZAI1-LW-A (S1))
Program Officer
Roe, Joanad'Arc C
Project Start
2009-09-22
Project End
2012-08-31
Budget Start
2009-09-22
Budget End
2012-08-31
Support Year
12
Fiscal Year
2009
Total Cost
$316,208
Indirect Cost
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Lesko, Catherine R; Todd, Jonathan V; Cole, Stephen R et al. (2017) Mortality under plausible interventions on antiretroviral treatment and depression in HIV-infected women: an application of the parametric g-formula. Ann Epidemiol 27:783-789.e2
Reid, Michael; Ma, Yifei; Scherzer, Rebecca et al. (2017) Higher CD163 levels are associated with insulin resistance in hepatitis C virus-infected and HIV-infected adults. AIDS 31:385-393
McFarlane, Samy I; Mielke, Michelle M; Uglialoro, Anthony et al. (2017) Ghrelin, Amylin, Gastric Inhibitory Peptide and Cognition in Middle-Aged HIV-Infected and Uninfected Women: The Women's Interagency HIV Study. J Neurol Neurophysiol 8:
Haddad, Lisa B; Wall, Kristin M; Mehta, C Christina et al. (2017) Trends of and factors associated with live-birth and abortion rates among HIV-positive and HIV-negative women. Am J Obstet Gynecol 216:71.e1-71.e16
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Nabi, Rafiq; Moldoveanu, Zina; Wei, Qing et al. (2017) Differences in serum IgA responses to HIV-1 gp41 in elite controllers compared to viral suppressors on highly active antiretroviral therapy. PLoS One 12:e0180245
Kuniholm, Mark H; Liang, Hua; Anastos, Kathryn et al. (2017) Association of a 3' untranslated region polymorphism in proprotein convertase subtilisin/kexin type 9 with HIV viral load and CD4+ levels in HIV/hepatitis C virus coinfected women. AIDS 31:2483-2492
French, Audrey L; Martin, Jonathan W; Evans, Charlesnika T et al. (2017) Macrophage Activation and the Tumor Necrosis Factor Cascade in Hepatitis C Disease Progression Among HIV-Infected Women Participating in the Women's Interagency HIV Study. J Acquir Immune Defic Syndr 76:438-444

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