Improvingthe efficiencyof surveillancefor healthcare-associatedinfections,antimicrobialresistance,and otheradverse eventsbyoptimizingavailableelectronichealthinformationsystemsprovidesthecapacityfor facilitiestofocus lesson datacollectionandmore on improvingprocessesand outcomes.This may be _articuladytrue in smallcommunityhospitalswhere staffingandotherresourcesare limited. Enhanced .=lectronicsurveillancealone,however,is notsufficientto accomplishthesepreventiongoals. Acquisition andapplicationof performanceimprovementskillsandtoolsvia multidisciplinareyducationalmodesare alsorequired. Leveragingthe increasedcapacityof combiningelectronicsurveillancewith collaborativeneh,:orkingto implementenhancementsis thefocusof the OhioState HealthNetworkInfectionControlCollaborative(OSHNICC). The OSHNICC is builtonthe foundationof the OhioState UniversityHealthSystem (OSUHS) ('the supportfacilities'),withits highlyintegratedelectronichealthinformationsystem,combinedwith the existingOhioState HealthNetwork(OHSN). OHSN hasfor >10 yearselectronicallyandoperationallylinkedOSUHS with severaloutlyingreferral communitiesof varyingsizes(=theoutreachfacilities').The existingOSU InformationWarehouse(IW), a richrepositoryof healthinformation,willbeoptimizedfor surveillancebysystematicretrospectiveidentificationof reliablesurrogatemarkersfor targetedevents,retrospedivecomparisonof electronicwithtraditionalsurveillancefor accuracy,and proposectivevalidationof surveillancemethodolgyfor accuracyand costefficiency. The existingelectronicinterfacebehveenOSUHS andoutreachfacilitieswillbe usedto expandelectronicsurveillancecapabilitytothesefacilities. Concurrently,organized multifacetedcollaborationto improveinfectioncontrolprocessinOSHNICC faciltieswill be conductedwithstandardizedlongitudinaml onitoringof processand outcomemeasuresas the metric for success. Enhancedelectronicsurveillancefor targeted pathogenswithantimicrobial resistancewill be institutedacrossthe entirenetworkwithrapidepidemiologicand molecularcharacterizationof transmission.Collaborativeinterventionsto improvebothprocessandoutcomeswillbetested_,;Athinthisne_h'_' orkusinga grouprandomizationstudydesign.The economicimpactof all phasesofthe init_tiath/ewill be estimated.P.-_OPJ2.A.NCE SFFE(S) (o_an_-.atJonc.ity, state)The Ohio State Unk,ersity, Columbus,OHBamesville Hospital,Bamesville,OHBamesville Health Care Center, Barnesville,OHMonroe CountyCare Center, Bamesville,OHMadison County Hospital,London,OHArbors at London,London,OHWoodsfieldNursingand RehabilitationCenter,Woodsfield,OHWyandotMemorial Hospital,Upper Sandusky,OH FairhavenCommunity,UpperSandusky,OHWyandot Manor, Upper Sandusky, OHMary Rutan Hospital, Bellefontaine, OHLoganAcres, Bellefontaine, OHBucyrusCommunityHospital,Bucyrus,OHAltercare of Bucyrus,Bucyrus,OHHeartlandof Bucyrus,Bucyrus,OHPHS 3_S(R_#. C'_.'34) Page 2_ Form Page 2 P,_.,.._.a!I,,'_est_jat:dProgramDirector(Last, First, Middle): Stevenson, Kurt BrownKEY PERSO._._-EL See..i:_='m_,c,-ts.Use conb'nuaEonpages as needed to provide the requiredinformation in the format shown below.S_a_v,'_hPL. '-P_..alI,,'w?s'_atcr.Us'.a,q _er key personnelin alphabeticalorder,lastname firsLt_a.,'_e eRA Commons User Name Organization Roleon ProjectStevenson, Kurt Brown INF_55CNTRL Ohio State University Principal InvestigatorCaswe11R, obert J. Ohio State University Co-InvestigatorJarjoura, David Ohio State University Co-lnvestigatorKamal, Jyoti Ohio State University Co-InvestigatorLemeshow, Stanley Ohio State University Co-InvestigatorMangino, Julie Ohio State University Co-InvestigatorMurray, David Ohio State University Co-InvestigatorPancholi, Preeti Ohio State University Co-InvestigatorWang, Shu-Hua Ohio State University Co-InvestigatorOTHER SIG,_'_FICANTCONTRIBUTORSt'&me Organization Role on ProjectBrady, Michael Columbus Children's Hospital Technical advisor-ResistanceSaltz, Joel H. Ohio State University Technical advisor- InforrnaticsHuman Embryonic Stem Ceils [] No [] YestfL%eproposedprojectInvolveshumanembryonicstem cells, list below the registrationumberof thespecificcell line(s)from the followinglist:h.'tD:llstemce!Is.n_h.aovlreaistry_nde .asD. Use conEnuationpages as needed.Ifa s:>e'_..,I:LneC=L'z'l,:cetre.'_-enc_dat_ _Emei.ncludea statementhatonefromtheRegistrywill beused.C,e_lUneDisclosure Pen'nission Statement. App_cabTeto SBIR/STTR Only. See SBIPJSTTRinstructions. [] Yes [] NoPHS 3_3 (Re-,,.09..'34) Page3-- Form Page 2-continuedNumbetrhefoflowingpagesconsecuth'etfhyroughouttheapplicaSonD.onotusesufSxesuchas4a,4b. P_-.,._,a_I:w-est_gator/ProgramDirector(Last. First, Middle): Stevenson, Kurt BrownThe r.a..me f t,hepr_'_cipailnvest}gatorlprogramdirector must be provided at the top of each pdnted page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page NumbersFace Page.................................................................................................................................................. 1Description,

Agency
National Institute of Health (NIH)
Institute
National Center for Infectious Diseases (CID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CI000328-05
Application #
7792394
Study Section
Special Emphasis Panel (ZCI1-TYM (10))
Program Officer
Llata, Eloisa
Project Start
2006-02-01
Project End
2012-01-31
Budget Start
2010-03-15
Budget End
2012-01-31
Support Year
5
Fiscal Year
2010
Total Cost
$463,586
Indirect Cost
Name
Ohio State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Lin, Michael Y; Woeltje, Keith F; Khan, Yosef M et al. (2014) Multicenter evaluation of computer automated versus traditional surveillance of hospital-acquired bloodstream infections. Infect Control Hosp Epidemiol 35:1483-90
Wang, Shu-Hua; Khan, Yosef; Hines, Lisa et al. (2012) Methicillin-resistant Staphylococcus aureus sequence type 239-III, Ohio, USA, 2007-2009. Emerg Infect Dis 18:1557-65
Dubberke, Erik R; Nyazee, Humaa A; Yokoe, Deborah S et al. (2012) Implementing automated surveillance for tracking Clostridium difficile infection at multiple healthcare facilities. Infect Control Hosp Epidemiol 33:305-8
Kasper, Amelia M; Nyazee, Humaa A; Yokoe, Deborah S et al. (2012) A multicenter study of Clostridium difficile infection-related colectomy, 2000-2006. Infect Control Hosp Epidemiol 33:470-6
Yokoe, Deborah S; Khan, Yosef; Olsen, Margaret A et al. (2012) Enhanced surgical site infection surveillance following hysterectomy, vascular, and colorectal surgery. Infect Control Hosp Epidemiol 33:768-73
Schwartz, David N; Evans, R Scott; Camins, Bernard C et al. (2011) Deriving measures of intensive care unit antimicrobial use from computerized pharmacy data: methods, validation, and overcoming barriers. Infect Control Hosp Epidemiol 32:472-80
Dubberke, Erik R; Butler, Anne M; Nyazee, Humaa A et al. (2011) The impact of ICD-9-CM code rank order on the estimated prevalence of Clostridium difficile infections. Clin Infect Dis 53:20-5
Hota, Bala; Lin, Michael; Doherty, Joshua A et al. (2010) Formulation of a model for automating infection surveillance: algorithmic detection of central-line associated bloodstream infection. J Am Med Inform Assoc 17:42-8
Dubberke, Erik R; Butler, Anne M; Yokoe, Deborah S et al. (2010) Multicenter study of surveillance for hospital-onset Clostridium difficile infection by the use of ICD-9-CM diagnosis codes. Infect Control Hosp Epidemiol 31:262-8
Dubberke, Erik R; Butler, Anne M; Yokoe, Deborah S et al. (2010) Multicenter study of Clostridium difficile infection rates from 2000 to 2006. Infect Control Hosp Epidemiol 31:1030-7

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