Birth defects affect 1 in every 33 babies at birth, and up to 1 in every 20 children by the time they are five years of age. The long term goal is to prevent birth defects and reduce their adverse consequences. Because most birth defects still have no identifiable cause, the Centers for Disease Control and Prevention established the National Birth Defects Prevention Study (NBDPS) in 1997. This population-based case control study represents a nationwide effort to identify causes of birth defects as a basis for primary prevention. The Utah Center for Birth Defects Research and Prevention joined this study in 2002. The Utah center uses the Utah Birth Defect Network, a population-based surveillance program, as the basis for identifying babies with birth defects. Building on the established infrastructure developed in Utah since joining the NBDPS, the overall objectives of this proposal are to expand the resource of epidemiological information and genetic data on birth defects, and to extend the Utah center's investigations on how environmental and genetic factors, alone or in combination, influence the risk for birth defects.
The specific aims are to: (1) Ascertain and recruit a minimum of 300 eligible infants with birth defects ("cases") and 100 infants without birth defects ("controls") each year. Cases will be ascertained from the statewide population-based surveillance program. All cases will undergo expert review by a clinical geneticist. Healthy live born controls will be selected as a random sample of Utah's newborns from statewide birth certificates. (2) Interview study participants (i.e., mothers) and collect biological samples (DNA) from each family "trio" (mother, father, and baby). Mothers willing to participate will be interviewed using a computer-assisted telephone interview. If consent is given, DNA from family trios will be obtained from buccal (cheek cell) swabs, and additional DNA from newborn blood spots. (3) Analyze and disseminate surveillance data, identify environmental risk factors for birth defects, and create and initiate projects to find genetic risk factors for birth defects. In addition to analyzing and disseminating data on birth defect surveillance on an ongoing basis, the Utah center will develop and complete epidemiological and genetic studies on risk factors for birth defects using the collective NBDPS resource. The findings from the proposed project will provide the basis for developing strategies aimed at modifying risk factors for birth defects in the population. In doing so, the project will contribute to reducing the burden of birth defects and improving the chance that babies are born healthy, without birth defects.

Public Health Relevance

Births defects are common and serious conditions that affect 1 out of every 33 babies and are the leading cause of death in the first year of life. This proposal seeks to find and characterize what genes and factors in the environment, now mostly unknown, cause these birth defects. These findings will help develop ways to modify these risk factors so that we can increase the chance that babies will be born healthy, without birth defects.

Agency
National Institute of Health (NIH)
Institute
Centers for Disease Control and Prevention (NCBDD)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DD000490-05
Application #
8398907
Study Section
Special Emphasis Panel (ZCD1-SGI (06))
Program Officer
Brown, Michael
Project Start
2008-12-01
Project End
2014-11-30
Budget Start
2012-12-01
Budget End
2014-11-30
Support Year
5
Fiscal Year
2013
Total Cost
$583,787
Indirect Cost
$18,270
Name
Utah State Department of Health
Department
Type
DUNS #
959347972
City
Salt Lake City
State
UT
Country
United States
Zip Code
84114
Feldkamp, Marcia L; Carmichael, Suzan L; Shaw, Gary M et al. (2011) Maternal nutrition and gastroschisis: findings from the National Birth Defects Prevention Study. Am J Obstet Gynecol 204:404.e1-404.e10
Feldkamp, Marcia L; Carey, John C; Pimentel, Richard et al. (2011) Is gastroschisis truly a sporadic defect?: familial cases of gastroschisis in Utah, 1997 to 2008. Birth Defects Res A Clin Mol Teratol 91:873-8