? The overall goal of the proposed research project is to establish the Data Coordinating Center (DCC) for the Pacific Northwest Dental Practice Based Research Network (PNW/DPBRN). Both the DCC and the PNW/DPBRN will be based at the University of Washington School of Dentistry. The DCC will build on the strengths of an existing Biostatistics group that has a successful long-term track record in biostatistical methodologic research and collaboration in clinical dental research, as well as the expertise and extensive experience of Axio Research, a Contract Research Organization nearby in downtown Seattle. In response to RFA-DE-05-006 issued by the NIDCR, the DCC will provide the scientific leadership in design and implementation of clinical research and the infrastructure needed for the conduct of multiple clinical trials and prospective observational studies to address important oral health care questions.
Five specific aims will be achieved: 1) Establish the infrastructure and develop Standard Operating Procedures for the DCC; 2) Create a reliable and customizable Web portal for commincations throughout the Network; 3) Participate with the Network Chair in training programs; 4) Assist Network members and Network Chair investigators in the design and initiation of at least 20 research studies, and ensure that IRB approvals are obtained before any patients are enrolled; and 5) Provide all biostatistical support for the implementation of approximately 20 approved research studies, including the coordination of the Data and Safety Monitoring Board.
These specific aims will be achieved by a team of investigators with complementary sets of expertise and experience. The Director of the DCC will be Dr. Brian Leroux, who currently leads a large active Biostatistics group at the University of Washington School of Dentistry. Key roles will be played by Dr. Lloyd Mancl, in Biostatistics, Dr. Philippe Hujoel, in Epidemiology and Study Design, and Jeffrey Sherman, in Behavioral Science, all at the University of Washington. The Data Management and IT Support Unit will be led by Ms. Ruth McBride, who has extensive experience managing coordinating centers for major NIHsponsored clinical trials in cardiovascular and pulmonary diseases, as well as industry-sponsored trials in a variety of clinical disease areas. Together, these investigators have the necessary expertise and experience in all areas that are critical for the success of the Data Coordinating Center for support of clinical dental research in the Pacific Northwest Dental Practice Based Research Network ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DE016752-02
Application #
7046840
Study Section
Special Emphasis Panel (ZDE1-RR (02))
Program Officer
Denucci, D J
Project Start
2005-04-01
Project End
2012-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
2
Fiscal Year
2006
Total Cost
$942,221
Indirect Cost
Name
University of Washington
Department
Dentistry
Type
Schools of Dentistry
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Horst, Orapin V; Cunha-Cruz, Joana; Zhou, Lingmei et al. (2015) Prevalence of pain in the orofacial regions in patients visiting general dentists in the Northwest Practice-based REsearch Collaborative in Evidence-based DENTistry research network. J Am Dent Assoc 146:721-8.e3
Ramsay, Douglas S; Rothen, Marilynn; Scott, JoAnna M et al. (2015) Tooth wear and the role of salivary measures in general practice patients. Clin Oral Investig 19:85-95
Rothen, Marilynn; Cunha-Cruz, Joana; Zhou, Lingmei et al. (2014) Oral hygiene behaviors and caries experience in Northwest PRECEDENT patients. Community Dent Oral Epidemiol 42:526-35
Cunha-Cruz, Joana; Rothen, Marilynn; Spiekerman, Charles et al. (2014) Recommendations for third molar removal: a practice-based cohort study. Am J Public Health 104:735-43
Huang, Greg J; Cunha-Cruz, Joana; Rothen, Marilynn et al. (2014) A prospective study of clinical outcomes related to third molar removal or retention. Am J Public Health 104:728-34
McBride, Ruth; Leroux, Brian; Lindblad, Anne et al. (2013) Measuring the impact of practice-based research networks on member dentists in the Collaboration on Networked Dental and Oral Health Research, CONDOR. J Dent 41:393-403
Cunha-Cruz, Joana; Scott, JoAnna; Rothen, Marilynn et al. (2013) Salivary characteristics and dental caries: evidence from general dental practices. J Am Dent Assoc 144:e31-40
Heaton, L J; Leroux, B G; Ruff, P A et al. (2013) Computerized dental injection fear treatment: a randomized clinical trial. J Dent Res 92:37S-42S
Botello-Harbaum, Maria T; Demko, Catherine A; Curro, Frederick A et al. (2013) Information-seeking behaviors of dental practitioners in three practice-based research networks. J Dent Educ 77:152-60
Cunha-Cruz, Joana; Wataha, John C; Heaton, Lisa J et al. (2013) The prevalence of dentin hypersensitivity in general dental practices in the northwest United States. J Am Dent Assoc 144:288-96

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