Between 2002-2006, the prospective Chronic Renal Insufficiency Cohort (CRIC) Study enrolled >3400 adults with chronic kidney disease to address overarching goals of identifying predictors of rapid progression of kidney disease and clarifying the relationship between kidney dysfunction and the risks of sub-clinical and clinical cardiovascular events, death, and resource utilization through an initial 5-year follow-up. The proposed CRIC-2 extended follow-up through to June 30, 2012 offers a unique opportunity to leverage the existing effort and success of CRIC-1 to establish a cohort of participants with chronic kidney disease who have long-term prospective follow-up on progression of kidney disease and a variety of different outcomes. This unparalleled resource will also expand the science related to chronic kidney disease natural history as well as the impact on cardiovascular disease and other adverse events.
Specific Aims to be addressed by the Kaiser Permanente of Northern California/UCSF Clinical Center are:
Aim 1. To re-enroll a high percentage of participants into CRIC-2 extended follow-up and maintain high retention rates throughout the study.
Aim 2. To collect exposure and outcome data per the CRIC Phase 1 and 2 protocols.
Aim 3. To obtain, process and transfer biospecimens to the CRIC laboratory and NIDDK biorepository.
Aim 4. To investigate self-reported clinical events and obtain supporting medical records and documentation for adjudication of study outcomes.
Aim 5. To implement local quality assurance and quality control procedures in order to obtain standardized, high quality data.
Aim 6. To monitor routinely data collection, data management and follow-up rates.
Aim 7. To participate proactively in governance and oversight of the CRIC Study through study-wide committees and related functions.
Aim 8. To contribute to and participate in publishing and presenting findings from the CRIC Study.
Aim 9. To promote and support the established CRIC Study Ancillary Studies Program, including collaboration with the broader nephrology research community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK060902-12
Application #
8323103
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (M2))
Program Officer
Kusek, John W
Project Start
2001-09-30
Project End
2013-08-18
Budget Start
2012-05-01
Budget End
2013-08-18
Support Year
12
Fiscal Year
2012
Total Cost
$935,784
Indirect Cost
$411,659
Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
150829349
City
Oakland
State
CA
Country
United States
Zip Code
94612
Park, Meyeon; Hsu, Chi-Yuan; Go, Alan S et al. (2017) Urine Kidney Injury Biomarkers and Risks of Cardiovascular Disease Events and All-Cause Death: The CRIC Study. Clin J Am Soc Nephrol 12:761-771
Hsu, Jesse Yenchih; Roy, Jason A; Xie, Dawei et al. (2017) Statistical Methods for Cohort Studies of CKD: Survival Analysis in the Setting of Competing Risks. Clin J Am Soc Nephrol 12:1181-1189
Munoz Mendoza, Jair; Isakova, Tamara; Cai, Xuan et al. (2017) Inflammation and elevated levels of fibroblast growth factor 23 are independent risk factors for death in chronic kidney disease. Kidney Int 91:711-719
Kurella Tamura, Manjula; Vittinghoff, Eric; Hsu, Chi-Yuan et al. (2017) Loss of executive function after dialysis initiation in adults with chronic kidney disease. Kidney Int 91:948-953
Dubin, Ruth F; Deo, Rajat; Bansal, Nisha et al. (2017) Associations of Conventional Echocardiographic Measures with Incident Heart Failure and Mortality: The Chronic Renal Insufficiency Cohort. Clin J Am Soc Nephrol 12:60-68
Yang, Wei; Jepson, Christopher; Xie, Dawei et al. (2017) Statistical Methods for Recurrent Event Analysis in Cohort Studies of CKD. Clin J Am Soc Nephrol 12:2066-2073
Hsu, Chi-Yuan; Xie, Dawei; Waikar, Sushrut S et al. (2017) Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression. Kidney Int 91:196-203
Scialla, Julia J; Asplin, John; Dobre, Mirela et al. (2017) Higher net acid excretion is associated with a lower risk of kidney disease progression in patients with diabetes. Kidney Int 91:204-215
Grams, Morgan E; Yang, Wei; Rebholz, Casey M et al. (2017) Risks of Adverse Events in Advanced CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 70:337-346
Mehta, Rupal; Cai, Xuan; Hodakowski, Alexander et al. (2017) Fibroblast Growth Factor 23 and Anemia in the Chronic Renal Insufficiency Cohort Study. Clin J Am Soc Nephrol 12:1795-1803

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