Between 2002-2006, the prospective Chronic Renal Insufficiency Cohort (CRIC) Study enrolled >3400 adults with chronic kidney disease to address overarching goals of identifying predictors of rapid progression of kidney disease and clarifying the relationship between kidney dysfunction and the risks of sub-clinical and clinical cardiovascular events, death, and resource utilization through an initial 5-year follow-up. The proposed CRIC-2 extended follow-up through to June 30, 2012 offers a unique opportunity to leverage the existing effort and success of CRIC-1 to establish a cohort of participants with chronic kidney disease who have long-term prospective follow-up on progression of kidney disease and a variety of different outcomes. This unparalleled resource will also expand the science related to chronic kidney disease natural history as well as the impact on cardiovascular disease and other adverse events.
Specific Aims to be addressed by the Kaiser Permanente of Northern California/UCSF Clinical Center are:
Aim 1. To re-enroll a high percentage of participants into CRIC-2 extended follow-up and maintain high retention rates throughout the study.
Aim 2. To collect exposure and outcome data per the CRIC Phase 1 and 2 protocols.
Aim 3. To obtain, process and transfer biospecimens to the CRIC laboratory and NIDDK biorepository.
Aim 4. To investigate self-reported clinical events and obtain supporting medical records and documentation for adjudication of study outcomes.
Aim 5. To implement local quality assurance and quality control procedures in order to obtain standardized, high quality data.
Aim 6. To monitor routinely data collection, data management and follow-up rates.
Aim 7. To participate proactively in governance and oversight of the CRIC Study through study-wide committees and related functions.
Aim 8. To contribute to and participate in publishing and presenting findings from the CRIC Study.
Aim 9. To promote and support the established CRIC Study Ancillary Studies Program, including collaboration with the broader nephrology research community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK060902-12
Application #
8323103
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (M2))
Program Officer
Kusek, John W
Project Start
2001-09-30
Project End
2013-08-18
Budget Start
2012-05-01
Budget End
2013-08-18
Support Year
12
Fiscal Year
2012
Total Cost
$935,784
Indirect Cost
$411,659
Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
150829349
City
Oakland
State
CA
Country
United States
Zip Code
94612
Denburg, Michelle R; Hoofnagle, Andrew N; Sayed, Samir et al. (2016) Comparison of Two ELISA Methods and Mass Spectrometry for Measurement of Vitamin D-Binding Protein: Implications for the Assessment of Bioavailable Vitamin D Concentrations Across Genotypes. J Bone Miner Res 31:1128-36
Tangri, Navdeep; Grams, Morgan E; Levey, Andrew S et al. (2016) Multinational Assessment of Accuracy of Equations for Predicting Risk of Kidney Failure: A Meta-analysis. JAMA 315:164-74
Navaneethan, Sankar D; Roy, Jason; Tao, Kelvin et al. (2016) Prevalence, Predictors, and Outcomes of Pulmonary Hypertension in CKD. J Am Soc Nephrol 27:877-86
Amdur, Richard L; Feldman, Harold I; Gupta, Jayanta et al. (2016) Inflammation and Progression of CKD: The CRIC Study. Clin J Am Soc Nephrol 11:1546-56
Gutiérrez, Orlando M; Parsa, Afshin; Isakova, Tamara et al. (2016) Genetic African Ancestry and Markers of Mineral Metabolism in CKD. Clin J Am Soc Nephrol 11:653-62
Mills, Katherine T; Chen, Jing; Yang, Wei et al. (2016) Sodium Excretion and the Risk of Cardiovascular Disease in Patients With Chronic Kidney Disease. JAMA 315:2200-10
Mehta, Rupal; Cai, Xuan; Lee, Jungwha et al. (2016) Association of Fibroblast Growth Factor 23 With Atrial Fibrillation in Chronic Kidney Disease, From the Chronic Renal Insufficiency Cohort Study. JAMA Cardiol 1:548-56
Fischer, Michael J; Hsu, Jesse Y; Lora, Claudia M et al. (2016) CKD Progression and Mortality among Hispanics and Non-Hispanics. J Am Soc Nephrol 27:3488-3497
Wang, Grace J; Shaw, Pamela A; Townsend, Raymond R et al. (2016) Sex Differences in the Incidence of Peripheral Artery Disease in the Chronic Renal Insufficiency Cohort. Circ Cardiovasc Qual Outcomes 9:S86-93
He, Jiang; Mills, Katherine T; Appel, Lawrence J et al. (2016) Urinary Sodium and Potassium Excretion and CKD Progression. J Am Soc Nephrol 27:1202-12

Showing the most recent 10 out of 111 publications