Chronic kidney disease (CKD) has become an important public health challenge in the United States. CKD is a major risk factor for end-stage renal disease (ESRD), cardiovascular disease (CVD), and premature death. Understanding novel risk factors for the progression of CKD and associated CVD may help to develop effective approaches for early intervention in order to reduce the adverse disease burden. The Chronic Renal Insufficiency Cohort (CRIC) Study is a NIDDK-sponsored multi-center prospective cohort study. The overall objective of the CRIC study is to investigate novel risk factors for the progression of CKD and development of CVD among patients with chronic renal insufficiency. The CRIC study has recruited 3,612 adult patients with CKD from 7 clinical centers in the US. The study participants are followed for renal and cardiovascular outcomes up to 5 years in the initial phase (CRIC phase-1). The CRIC Tulane Clinical Center recruited 405 study participants and achieved a respective follow-up rate despite devastation caused by hurricane Katrina in the New Orleans area. The proposed CRIC phase-2 which extends follow-up through 2013, offers a unique opportunity to leverage the existing effort and success of CRIC to establish a cohort of CKD participants who have long-term prospective follow-up on progression of kidney disease and a variety of different outcomes. This unparalleled resource will also expand the science related to CKD natural history as well as the impact on CVD and other adverse events.
Specific aims to be addressed by the Tulane Clinical Center are: (1). to re-enroll a high percentage of CRIC phase-1 participants into phase-2;(2). to collect exposure and outcome data per the CRIC phase 1 and 2 protocols;(3). to maintain high levels of retention in the study;(4). to investigate self-reported clinical events and obtain supporting medical records and documentation;(5). to enter data and process/ship biological specimens;(6). to implement local quality assurance and quality control procedures as a means to obtain standardized, high quality measurements;(7). to monitor data collection, data entry, and follow-up rates;(8). to participate in governance and oversight of the CRIC study through study-wide subcommittees and activities;(9). to publish and present findings from the CRIC Study;and (10). to promote and support the conduct of ancillary studies in CRIC, including collaboration with the broader nephrology research community. The proposed study may provide insights into the underlying etiology of progression of CKD and related CVD and information for developing further intervention studies aimed at reducing morbidity and mortality of ESRD and CVD among patients with CKD.
|Bansal, Nisha; McCulloch, Charles E; Lin, Feng et al. (2016) Different components of blood pressure are associated with increased risk of atherosclerotic cardiovascular disease versus heart failure in advanced chronic kidney disease. Kidney Int 90:1348-1356|
|Porter, Anna C; Lash, James P; Xie, Dawei et al. (2016) Predictors and Outcomes of Health-Related Quality of Life in Adults with CKD. Clin J Am Soc Nephrol 11:1154-62|
|Liu, Xun; Foster, Meredith C; Tighiouart, Hocine et al. (2016) Non-GFR Determinants of Low-Molecular-Weight Serum ProteinÂ Filtration Markers in CKD. Am J Kidney Dis 68:892-900|
|Dobre, Mirela; Roy, Jason; Tao, Kaixiang et al. (2016) Serum Bicarbonate and Structural and Functional Cardiac Abnormalities in Chronic Kidney Disease - A Report from the Chronic Renal Insufficiency Cohort Study. Am J Nephrol 43:411-20|
|Gupta, Jayanta; Mitra, Nandita; Townsend, Raymond R et al. (2016) Variants in genes belonging to the fibroblast growth factor family are associated with lower extremity amputation in non-Hispanic whites: Findings from the chronic renal insufficiency cohort study. Wound Repair Regen 24:705-11|
|Inker, Lesley A; Tighiouart, Hocine; Coresh, Josef et al. (2016) GFR Estimation Using Î²-Trace Protein and Î²2-Microglobulin inÂ CKD. Am J Kidney Dis 67:40-8|
|Ricardo, Ana C; Roy, Jason A; Tao, Kaixiang et al. (2016) Influence of Nephrologist Care on Management and Outcomes in Adults with Chronic Kidney Disease. J Gen Intern Med 31:22-9|
|Kurella Tamura, Manjula; Vittinghoff, Eric; Yang, Jingrong et al. (2016) Anemia and risk for cognitive decline in chronic kidney disease. BMC Nephrol 17:13|
|Deo, Rajat; Shou, Haochang; Soliman, Elsayed Z et al. (2016) Electrocardiographic Measures and Prediction of Cardiovascular and Noncardiovascular Death in CKD. J Am Soc Nephrol 27:559-69|
|Drawz, Paul E; Alper, Arnold B; Anderson, Amanda H et al. (2016) Masked Hypertension and Elevated Nighttime Blood Pressure in CKD: Prevalence and Association with Target Organ Damage. Clin J Am Soc Nephrol 11:642-52|
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