Between 2002-2012, the NIDDK-sponsored prospective Chronic Renal Insufficiency Cohort (CRIC) Study enrolled 3939 adults with chronic kidney disease (CKD) at 7 Clinical Centers to address overarching goals of identifying risk factors for CKD progression and clarifying the relationship between kidney dysfunction and the risks of subclinical and clinical cardiovascular events, death, and resource utilization through an initial 10-year follow-up of CRIC-Phase 1. Phase 2 of CRIC, extended follow-up through April 30, 2013. This application is submitted in response to RFA-DK-12-508, """"""""Limited Competition: Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01),"""""""" on behalf of the University of Pennsylvania (Penn) Clinical Center. In Phases 1 and 2 of CRIC, the Penn was a model site that exceeded its recruitment goal, achieved high follow-up rates and outstanding data quality, and that contributed actively to study-wide governance and implementation. In Phase 3, the Penn clinical center has the following specific aims: 1. To re-enroll a high percentage of CRIC Phase 1 participants into Phase 3 of CRIC 2. To enroll an additional 214 participants into Phase 3 of CRIC 3. To collect exposure and outcome data per the CRIC Phase 3 protocol 4. To maintain high levels of retention in the study 5. To investigate self reported clinical events and obtain supporting medical records and documentation. 6. To enter data and process/ship biological specimens. 7. To implement local quality assurance and quality control procedures as a means to obtain standardized, high quality measurements 8. To monitor data collection, data entry, and follow-up rates 9. To participate in governance and oversight of CRIC through study wide subcommittees and activities 10. To publish and present findings from the CRIC Study 11. To promote and support the conduct of ancillary studies in CRIC, including collaboration with the broader nephrology research community. We look forward to the opportunity to continue participation in this unique and important study.

Public Health Relevance

The CRIC study is a federally funded longitudinal observation study focused on chronic kidney disease. In the first two phases of CRIC 3939 patients with CKD, half with diabetes, were recruited and followed up to the current time. In phase 3 of CRIC we anticipate recruiting new participants to both replace those lost to death or withdrawn, and also to address important gaps in CKD including the elderly and those with minimally impaired kidney function.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK060984-14
Application #
8722534
Study Section
Special Emphasis Panel (ZDK1-GRB-N (M1))
Program Officer
Kusek, John W
Project Start
2001-09-28
Project End
2018-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
14
Fiscal Year
2014
Total Cost
$820,000
Indirect Cost
$289,034
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Bansal, Nisha; McCulloch, Charles E; Lin, Feng et al. (2016) Different components of blood pressure are associated with increased risk of atherosclerotic cardiovascular disease versus heart failure in advanced chronic kidney disease. Kidney Int 90:1348-1356
Porter, Anna C; Lash, James P; Xie, Dawei et al. (2016) Predictors and Outcomes of Health-Related Quality of Life in Adults with CKD. Clin J Am Soc Nephrol 11:1154-62
Liu, Xun; Foster, Meredith C; Tighiouart, Hocine et al. (2016) Non-GFR Determinants of Low-Molecular-Weight Serum Protein Filtration Markers in CKD. Am J Kidney Dis 68:892-900
Dobre, Mirela; Roy, Jason; Tao, Kaixiang et al. (2016) Serum Bicarbonate and Structural and Functional Cardiac Abnormalities in Chronic Kidney Disease - A Report from the Chronic Renal Insufficiency Cohort Study. Am J Nephrol 43:411-20
Gupta, Jayanta; Mitra, Nandita; Townsend, Raymond R et al. (2016) Variants in genes belonging to the fibroblast growth factor family are associated with lower extremity amputation in non-Hispanic whites: Findings from the chronic renal insufficiency cohort study. Wound Repair Regen 24:705-11
Inker, Lesley A; Tighiouart, Hocine; Coresh, Josef et al. (2016) GFR Estimation Using β-Trace Protein and β2-Microglobulin in CKD. Am J Kidney Dis 67:40-8
Ricardo, Ana C; Roy, Jason A; Tao, Kaixiang et al. (2016) Influence of Nephrologist Care on Management and Outcomes in Adults with Chronic Kidney Disease. J Gen Intern Med 31:22-9
Kurella Tamura, Manjula; Vittinghoff, Eric; Yang, Jingrong et al. (2016) Anemia and risk for cognitive decline in chronic kidney disease. BMC Nephrol 17:13
Deo, Rajat; Shou, Haochang; Soliman, Elsayed Z et al. (2016) Electrocardiographic Measures and Prediction of Cardiovascular and Noncardiovascular Death in CKD. J Am Soc Nephrol 27:559-69
Drawz, Paul E; Alper, Arnold B; Anderson, Amanda H et al. (2016) Masked Hypertension and Elevated Nighttime Blood Pressure in CKD: Prevalence and Association with Target Organ Damage. Clin J Am Soc Nephrol 11:642-52

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