Between 2002-2012, the NIDDK-sponsored prospective Chronic Renal Insufficiency Cohort (CRIC) Study enrolled 3939 adults with chronic kidney disease (CKD) at 7 Clinical Centers to address overarching goals of identifying risk factors for CKD progression and clarifying the relationship between kidney dysfunction and the risks of subclinical and clinical cardiovascular events, death, and resource utilization through an initial 10-year follow-up of CRIC-Phase 1. Phase 2 of CRIC, extended follow-up through April 30, 2013. This application is submitted in response to RFA-DK-12-508, "Limited Competition: Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01)," on behalf of the University of Pennsylvania (Penn) Clinical Center. In Phases 1 and 2 of CRIC, the Penn was a model site that exceeded its recruitment goal, achieved high follow-up rates and outstanding data quality, and that contributed actively to study-wide governance and implementation. In Phase 3, the Penn clinical center has the following specific aims: 1. To re-enroll a high percentage of CRIC Phase 1 participants into Phase 3 of CRIC 2. To enroll an additional 214 participants into Phase 3 of CRIC 3. To collect exposure and outcome data per the CRIC Phase 3 protocol 4. To maintain high levels of retention in the study 5. To investigate self reported clinical events and obtain supporting medical records and documentation. 6. To enter data and process/ship biological specimens. 7. To implement local quality assurance and quality control procedures as a means to obtain standardized, high quality measurements 8. To monitor data collection, data entry, and follow-up rates 9. To participate in governance and oversight of CRIC through study wide subcommittees and activities 10. To publish and present findings from the CRIC Study 11. To promote and support the conduct of ancillary studies in CRIC, including collaboration with the broader nephrology research community. We look forward to the opportunity to continue participation in this unique and important study.

Public Health Relevance

The CRIC study is a federally funded longitudinal observation study focused on chronic kidney disease. In the first two phases of CRIC 3939 patients with CKD, half with diabetes, were recruited and followed up to the current time. In phase 3 of CRIC we anticipate recruiting new participants to both replace those lost to death or withdrawn, and also to address important gaps in CKD including the elderly and those with minimally impaired kidney function.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Project--Cooperative Agreements (U01)
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Special Emphasis Panel (ZDK1-GRB-N (M1))
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Kusek, John W
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University of Pennsylvania
Internal Medicine/Medicine
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United States
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Rahman, Mahboob; Yang, Wei; Akkina, Sanjeev et al. (2014) Relation of serum lipids and lipoproteins with progression of CKD: The CRIC study. Clin J Am Soc Nephrol 9:1190-8
Scialla, Julia J; Xie, Huiliang; Rahman, Mahboob et al. (2014) Fibroblast growth factor-23 and cardiovascular events in CKD. J Am Soc Nephrol 25:349-60
Ricardo, Ana C; Yang, Wei; Lora, Claudia M et al. (2014) Limited health literacy is associated with low glomerular filtration in the Chronic Renal Insufficiency Cohort (CRIC) study. Clin Nephrol 81:30-7
Chirinos, Julio A; Khan, Abigail; Bansal, Nisha et al. (2014) Arterial stiffness, central pressures, and incident hospitalized heart failure in the chronic renal insufficiency cohort study. Circ Heart Fail 7:709-16
Mariani, Laura H; White, Matthew T; Shults, Justine et al. (2014) Increasing use of vitamin D supplementation in the chronic renal insufficiency cohort study. J Ren Nutr 24:186-93
Wing, Maria R; Devaney, Joseph M; Joffe, Marshall M et al. (2014) DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study. Nephrol Dial Transplant 29:864-72
Yang, Wei; Xie, Dawei; Anderson, Amanda H et al. (2014) Association of kidney disease outcomes with risk factors for CKD: findings from the Chronic Renal Insufficiency Cohort (CRIC) study. Am J Kidney Dis 63:236-43
Wing, Maria R; Yang, Wei; Teal, Valerie et al. (2014) Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: findings from the chronic renal insufficiency cohort study. Obesity (Silver Spring) 22:1359-66
Grunwald, Juan E; Pistilli, Maxwell; Ying, Gui-Shuang et al. (2014) Retinopathy and progression of CKD: The CRIC study. Clin J Am Soc Nephrol 9:1217-24
Deo, Rajat; Yang, Wei; Khan, Abigail M et al. (2014) Serum aldosterone and death, end-stage renal disease, and cardiovascular events in blacks and whites: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study. Hypertension 64:103-10

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