This limited competition renewal application is for the Turku/Finland Clinical Center of The Environmental Determinants of Diabates in the Young (TEDDY) study. The primary objective of this multi-center, multi- national epidemiological study is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of islet autoimmunity and type 1 diabates mellitus (T1D). Factors affecting specific phenotypic manifestations such as early age of onset or rate of progression, or which provide protection from the development of T1D will also be identified. TEDDY is an observational cohort study in which newborns who are less than 4.5 months of age and have high risk HLA genotypes and come from the general population, or carry HLA risk alleles and are first-degree relatives of patients affected with T1D will be enrolled. Six Clinical Centers in the United States and Europe will screen 361,588 newborns of which it is anticipated that 17,804 will be eligible for enrollment, with just over 7,800 followed. Recruitment started in September 2004 and will continue until December 31, 2009. Participants will be followed to the age of 15 years. Identification of such etiologically important factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay or reverse T1D.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Project--Cooperative Agreements (U01)
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Study Section
Special Emphasis Panel (ZDK1-GRB-G (J1))
Program Officer
Spain, Lisa M
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Hospital District of Southwest Finland
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Roth, Roswith; Baxter, Judith; Vehik, Kendra et al. (2017) The feasibility of salivary sample collection in an international pediatric cohort: The the TEDDY study. Dev Psychobiol 59:658-667
Krischer, Jeffrey P; Liu, Xiang; Lernmark, Åke et al. (2017) The Influence of Type 1 Diabetes Genetic Susceptibility Regions, Age, Sex, and Family History on the Progression From Multiple Autoantibodies to Type 1 Diabetes: A TEDDY Study Report. Diabetes 66:3122-3129
Yang, J; Tamura, R N; Uusitalo, U M et al. (2017) Vitamin D and probiotics supplement use in young children with genetic risk for type 1 diabetes. Eur J Clin Nutr 71:1449-1454
Köhler, Meike; Beyerlein, Andreas; Vehik, Kendra et al. (2017) Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes: results from the TEDDY study. Acta Diabetol 54:1009-1017
Lönnrot, Maria; Lynch, Kristian F; Elding Larsson, Helena et al. (2017) Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study. Diabetologia 60:1931-1940
Johnson, Suzanne Bennett; Lynch, Kristian F; Roth, Roswith et al. (2017) My Child Is Islet Autoantibody Positive: Impact on Parental Anxiety. Diabetes Care 40:1167-1172
Kemppainen, Kaisa M; Vehik, Kendra; Lynch, Kristian F et al. (2017) Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity. JAMA Pediatr 171:1217-1225
Koletzko, Sibylle; Lee, Hye-Seung; Beyerlein, Andreas et al. (2017) Caesarean Section on The Risk of Celiac Disease in the Offspring: The Teddy Study. J Pediatr Gastroenterol Nutr :
Steck, Andrea K; Larsson, Helena Elding; Liu, Xiang et al. (2017) Residual beta-cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controls. Pediatr Diabetes 18:794-802
Yang, Jimin; Tamura, Roy N; Aronsson, Carin A et al. (2017) Maternal use of dietary supplements during pregnancy is not associated with coeliac disease in the offspring: The Environmental Determinants of Diabetes in the Young (TEDDY) study. Br J Nutr 117:466-472

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