The long-term goals of the proposal are to establish a clinical center for the study and treatment of chronic pelvic pain in both genders and to co-operate with and contribute with other investigators in establishing and conducting multi-center clinical trials. In specific, this proposal is concerned with becoming a clinical site for the ICCRN. Our particular aims are to: (1) assist the ICCRN to establish study designs for clinical trials, develop forms and clinical definitions, recruit subjects for ICCRN trials, and to analyze and publish data in a co-operative and interactive manner; (2) support and take part in the Urological Chronic Pelvic Pain Syndromes Collaborative Group (UCPPSCG) in a co-operative and interactive manner; (3) develop and conduct ancillary studies, which will provide further understanding of Interstitial Cystitis (IC); and (4) assist in developing clinically relevant definitions of the urologic chronic pelvic pain syndromes, based on the clinical findings from these and other related clinical studies. Subjects will be recruited from the practice of Dr. Richard Berger, Dr. Jane Miller, and Dr. Elizabeth Miller at the University of Washington Medical Center (UWMC); the outpatient clinics at Group Health Cooperative of Puget Sound (GHC), a large health maintenance organization; and University of Washington Primary Care Network (UWPN), which comprises twelve community-based clinics. The investigators see approximately 500 new patients with frequency and urgency per year at UWMC. GHC sees approximately 300 patients per year with newly diagnosed frequency and urgency. UWPN sees 20,000 new patients per year cataloged by diagnosis by the end of 2002. By combining the patient population of both Seattle medical centers and the UWPN clinics, we will be able to recruit a mix of previously treated and newly diagnosed patients into ICCRN clinical protocols. The PI has a multidisciplinary team currently performing clinical and laboratory studies in CPPS in men. Over the past four years, the PI has enrolled 590 subjects into IRB-approved studies CPPS. The team members are ideally suited to contribute to designing and carrying out future protocols concerning IC performed by the ICCRN. Our multidisciplinary focus and experience will allow us the flexibility to design and carry out ancillary studies that will fit with the overall plan of the ICCRN.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK065202-03
Application #
7052914
Study Section
Special Emphasis Panel (ZDK1-GRB-1 (M2))
Program Officer
Kusek, John W
Project Start
2004-09-01
Project End
2008-02-28
Budget Start
2006-03-01
Budget End
2007-02-28
Support Year
3
Fiscal Year
2006
Total Cost
$244,125
Indirect Cost
Name
University of Washington
Department
Urology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
FitzGerald, M P; Payne, C K; Lukacz, E S et al. (2012) Randomized multicenter clinical trial of myofascial physical therapy in women with interstitial cystitis/painful bladder syndrome and pelvic floor tenderness. J Urol 187:2113-8
Yang, Claire C; Burks, David A; Propert, Kathleen J et al. (2011) Early termination of a trial of mycophenolate mofetil for treatment of interstitial cystitis/painful bladder syndrome: lessons learned. J Urol 185:901-6
Zhang, Dianzhong; Hudson, Amber E; Delostrinos, Catherine F et al. (2011) Dual sources of vitronectin in the human lower urinary tract: synthesis by urothelium vs. extravasation from the bloodstream. Am J Physiol Renal Physiol 300:F475-87
Hicks, Bryson G; Lopez, Erasmo A; Eastman Jr, Rocky et al. (2011) Differential affinity of vitronectin versus collagen for synthetic biodegradable scaffolds for urethroplastic applications. Biomaterials 32:797-807
Foster Jr, Harris E; Hanno, Philip M; Nickel, J Curtis et al. (2010) Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome. J Urol 183:1853-8
Eastman Jr, Rocky; Leaf, Elizabeth M; Zhang, Dianzhong et al. (2010) Fibroblast growth factor-10 signals development of von Brunn's nests in the exstrophic bladder. Am J Physiol Renal Physiol 299:F1094-110
Hudson, Amber E; Carmean, Nicole; Bassuk, James A (2007) Extracellular matrix protein coatings for facilitation of urothelial cell attachment. Tissue Eng 13:2219-25
Carmean, N; Kosman, J W; Leaf, E M et al. (2007) Immortalization of human urothelial cells by human papillomavirus type 16 E6 and E7 genes in a defined serum-free system. Cell Prolif 40:166-84