Prostatitis is a chronic, disabling condition affecting untold numbers of men of all ages and ethnic origins. We will participate in the Chronic Prostatitis Collaborative Research Network (CPCRN). Long-term goals are to prevent and effectively treat this condition.
Specific aims are to cooperate and interact with the other clinical centers, the Data Coordinating Center (DCC) and NIDDK staff to: 1) establish a collaborative group of clinical trial centers with expertise in chronic pelvic pain, clinical pain management, and chronic prostatitis 2) design randomized controlled clinical trials to treat the symptoms associated with chronic prostatitis 3) develop and conduct ancillary studies, which will provide further understanding of chronic prostatitis 4) determine if there is a different response to therapy between sub-groups of patients, including newly diagnosed and chronic, long-term patients 5) recruit a sufficient numbers of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), including an adequate number of newly diagnosed cases 6) jointly work with other CPCRN investigators, including the DCC, to analyze and interpret trial results 7) participate in the Urological Chronic Pelvic Pain Syndromes Collaborative Group (UCPPSCG) and 8) develop a clinically relevant definition of the urologic chronic pelvic pain syndromes, based on the clinical findings from these and other related clinical studies. Previous success in CP/CPPS studies allows us to meet the special requirements for this research including: the ability to recruit (and retain a high proportion of) at least 4-6 participants each month during years 2-4, the ability to recruit newly diagnosed cases, willingness to participate in a collaborative and interactive manner to develop the study protocols (both clinical trial and ancillary studies) and carry out the CPCRN trials, and willingness to participate in the UCPPSCG. We propose the following trial concept for consideration. Prior studies focused on refractory cases from tertiary referral centers. We propose to test the hypothesis that treatment outcomes in newly diagnosed cases are substantially better than in tertiary referral cases. We will screen the general population in Penang, Malaysia for new cases to compare with chronic cases from UW and other tertiary centers. Following clinical evaluation, CP/CPPS patients will be enrolled in a randomized clinical trial with a factorial design comparing alpha-blocker therapy, nonsteroidal anti-inflammatory therapy (or other therapies selected by the CPCRN), the combination, or placebo. Potential outcomes include: symptom indexes (e.g., the NIH-CPSI), urodynamics and inflammation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK065266-05
Application #
7235718
Study Section
Special Emphasis Panel (ZDK1-GRB-1 (M3))
Program Officer
Kusek, John W
Project Start
2003-09-05
Project End
2009-02-28
Budget Start
2007-03-01
Budget End
2009-02-28
Support Year
5
Fiscal Year
2007
Total Cost
$237,045
Indirect Cost
Name
University of Washington
Department
Urology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Lee, Shaun Wen Huey; Liong, Men Long; Yuen, Kah Hay et al. (2014) Acupuncture and immune function in chronic prostatitis/chronic pelvic pain syndrome: a randomized, controlled study. Complement Ther Med 22:965-9
Lee, Shaun Wen Huey; Liong, Men Long; Yuen, Kah Hay et al. (2011) Validation of a sham acupuncture procedure in a randomised, controlled clinical trial of chronic pelvic pain treatment. Acupunct Med 29:40-6
Pontari, Michel A; Krieger, John N; Litwin, Mark S et al. (2010) Pregabalin for the treatment of men with chronic prostatitis/chronic pelvic pain syndrome: a randomized controlled trial. Arch Intern Med 170:1586-93
Nickel, J Curtis; Alexander, Richard B; Anderson, Rodney et al. (2008) Category III chronic prostatitis/chronic pelvic pain syndrome: insights from the National Institutes of Health Chronic Prostatitis Collaborative Research Network studies. Curr Urol Rep 9:320-7
Nickel, J Curtis; Krieger, John N; McNaughton-Collins, Mary et al. (2008) Alfuzosin and symptoms of chronic prostatitis-chronic pelvic pain syndrome. N Engl J Med 359:2663-73
Lee, Shaun Wen Huey; Liong, Men Long; Yuen, Kah Hay et al. (2008) Adverse impact of sexual dysfunction in chronic prostatitis/chronic pelvic pain syndrome. Urology 71:79-84
Lee, Shaun Wen Huey; Liong, Men Long; Yuen, Kah Hay et al. (2008) Acupuncture versus sham acupuncture for chronic prostatitis/chronic pelvic pain. Am J Med 121:79.e1-7
Krieger, John N; Lee, Shaun Wen Huey; Jeon, Jeonseong et al. (2008) Epidemiology of prostatitis. Int J Antimicrob Agents 31 Suppl 1:S85-90
Lee, Shaun Wen Huey; Cheah, Phaik Yeong; Liong, Men Long et al. (2007) Demographic and clinical characteristics of chronic prostatitis: prospective comparison of the University of Sciences Malaysia Cohort with the United States National Institutes of Health Cohort. J Urol 177:153-7;discussion 158