The Hepatitis B Research Network (HBRN) was established in 2008 as a consortium of clinical and translational investigators studying novel aspects of hepatitis B disease. The focus of the HBRN has been to further elucidate the natural history of chronic hepatitis B in the United States and to conduct clinical trials comparing monotherapy versus combination therapy in immuneactive (IA) and immunetolerant (IT) populations. Numerous epidemiological studies utilizing the baseline data from the Adult Cohort Study have been implemented and several have been published or submitted for publication. Similarly, ancillary studies that will further our understanding of HBV pathogenesis, utilizing the robust clinical data linked with biospecimens, have been initiated. This renewal application will focus on continuing the extraordinary efforts of the HBRN, detail the integral role of The North Carolina Hepatitis B Research Consortium in this endeavor, and propose novel translational studies that will contribute to understanding HBV pathogenesis.

Public Health Relevance

Chronic hepatitis B is a major global health problem contributing to high rates of cirrhosis, liver failure, and hepatocellular carcinoma. The HepatitisB Research Network is an academic consortium of clinical and translational investigators performing studies to better understand the pathogenesis and treatment of chronic hepatitis B in North America. The North Carolina Hepatitis B Research Consortium will play a key role in this endeavor.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK082867-10
Application #
9315137
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Doo, Edward
Project Start
2008-09-30
Project End
2020-05-31
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
10
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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Evon, Donna M; Wahed, Abdus S; Johnson, Geoffrey et al. (2016) Fatigue in Patients with Chronic Hepatitis B Living in North America: Results from the Hepatitis B Research Network (HBRN). Dig Dis Sci 61:1186-96
Park, Jang-June; Wong, David K; Wahed, Abdus S et al. (2016) Hepatitis B Virus--Specific and Global T-Cell Dysfunction in Chronic Hepatitis B. Gastroenterology 150:684-695.e5
Khalili, Mandana; Lombardero, Manuel; Chung, Raymond T et al. (2015) Diabetes and prediabetes in patients with hepatitis B residing in North America. Hepatology 62:1364-74
Schwarz, Kathleen B; Cloonan, Yona Keich; Ling, Simon C et al. (2015) Children with Chronic Hepatitis B in the United States and Canada. J Pediatr 167:1287-1294.e2

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