The overall goal of the Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium is to identify effective behavioral and lifestyle interventions that will improve weight, glycemic control and other-pregnancy-related outcomes in obese and overweight pregnant women, and determine whether these interventions reduce obesity and metabolic abnormalities in their children. The Consortium will consist of clinical centers and a Research Coordinating Unit. Each clinical center within the Consortium will design and conduct an interventional study. -The Research Coordinating Unit will enhance the value of this research program by promoting collaboration, coordination and exchange of scientific information among the research investigators and NIH. These goals will be achieved by providing logistical and administrative support for meetings and calls, designing and maintaining an internal website for information exchange, preparing reports, linking datasets, disseminating results, and preparing limited access datasets for public use. The Research Coordinating Unit will assist with the design and implementation of the interventional studies, and will facilitate the design of the combined analyses across the studies by implementing common measures and methods. Additionally, the RCU will assist with data management, quality control and statistical analysis as required by the goals of the Consortium.

Public Health Relevance

The number of overweight or obese pregnant women is increasing and these women are at increased risk of poor pregnancy outcome and long term serious health problems such as diabetes and heart disease. In turn, the babies of overweight or obese women are at risk of obesity and overweight as they grow up, putting them also at risk for the same serious health problems. The purpose of this research is to find lifestyle and behavioral treatments for overweight and obese pregnant women that will improve outcomes for them and their children.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01DK094466-04S1
Application #
8919072
Study Section
Special Emphasis Panel (ZDK1-GRB-N (O2))
Program Officer
Evans, Mary
Project Start
2011-09-19
Project End
2016-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
4
Fiscal Year
2014
Total Cost
$206,494
Indirect Cost
$32,573
Name
George Washington University
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
043990498
City
Washington
State
DC
Country
United States
Zip Code
20052
Abraham, Manjusha; Collins, Christina A; Flewelling, Scott et al. (2018) Mitochondrial inefficiency in infants born to overweight African-American mothers. Int J Obes (Lond) 42:1306-1316
Gallagher, Dympna; Rosenn, Barak; Toro-Ramos, Tatiana et al. (2018) Greater Neonatal Fat-Free Mass and Similar Fat Mass Following a Randomized Trial to Control Excess Gestational Weight Gain. Obesity (Silver Spring) 26:578-587
Lewkowitz, Adam K; López, Julia D; Stein, Richard I et al. (2018) Effect of a Home-Based Lifestyle Intervention on Breastfeeding Initiation Among Socioeconomically Disadvantaged African American Women with Overweight or Obesity. Breastfeed Med 13:418-425
Sutton, Elizabeth F; Morrison, Christopher D; Stephens, Jacqueline M et al. (2018) Fibroblast growth factor 21, adiposity, and macronutrient balance in a healthy, pregnant population with overweight and obesity. Endocr Res 43:275-283
Peaceman, Alan M; Clifton, Rebecca G; Phelan, Suzanne et al. (2018) Lifestyle Interventions Limit Gestational Weight Gain in Women with Overweight or Obesity: LIFE-Moms Prospective Meta-Analysis. Obesity (Silver Spring) 26:1396-1404
Sutton, Elizabeth F; Cain, Loren E; Vallo, Porsha M et al. (2017) Strategies for Successful Recruitment of Pregnant Patients Into Clinical Trials. Obstet Gynecol 129:554-559
Redman, Leanne M; Gilmore, L Anne; Breaux, Jeffrey et al. (2017) Effectiveness of SmartMoms, a Novel eHealth Intervention for Management of Gestational Weight Gain: Randomized Controlled Pilot Trial. JMIR Mhealth Uhealth 5:e133
Clifton, Rebecca G; Evans, Mary; Cahill, Alison G et al. (2016) Design of lifestyle intervention trials to prevent excessive gestational weight gain in women with overweight or obesity. Obesity (Silver Spring) 24:305-13
Belle, Steven H; Stevens, June; Cella, David et al. (2016) Overview of the obesity intervention taxonomy and pooled analysis working group. Transl Behav Med 6:244-59
Torres, Roxana; Soltero, Sandra; Trak, Maria Angelica et al. (2016) Lifestyle modification intervention for overweight and obese Hispanic pregnant women: development, implementation, lessons learned and future applications. Contemp Clin Trials Commun 3:111-116