This proposal builds upon a five year research project, SEARCH for Diabetes in Youth, and its standardized data collection effort, experienced investigator team, established case ascertainment infrastructure, and ethnically diverse population base. This is a common, integrated application from the six SEARCH clinical sites, which proposes to continue and expand the work performed by SEARCH in order to address the following specific research aims:
AIM 1 : Prospectively ascertain newly diagnosed (2006-2008) incident cases age less than 20 years in order to estimate temporal trends in incidence of diabetes mellitus (DM) in youth;
AIM 2 : Conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2002-2005 in order to document the evolution of newly diagnosed DM according to clinical and biochemical factors;
AIM 3 : Complete analyses initiated in the first five years of SEARCH and expand the scope of quality of care assessment to encompass more broadly defined concepts and measures of quality;
AIM 4 : Develop and validate simple and low-cost case definitions and classifications of DM types in youth that can be used for public health surveillance. The novelty of this proposal includes its comprehensive nature that brings together major and timely facets of childhood DM research: an epidemiologic study, unique in the United States, of temporal trends in the incidence of DM in youth; a pathophysiologic component addressing the natural history of DM in youth; a study of processes of care and quality of life; and a public health perspective on case classification of DM in youth. This research is critically important to public health as it will provide information about whether and how much DM is increasing among youth of different racial/ethnic groups in the US, how DM impacts physical health, including complications, as well as valuable data regarding the quality of care and quality of life of these youth. The SEARCH Study in Hawaii is population-based, with the three health insurance plans participating in the study including in their membership nearly 80% of the population of the State. Approximately 80% of the youth enrolled in SEARCH in Hawaii belong to an ethnic minority group, primarily Asian/Pacific Islanders (API). The Hawaii Center had the highest response rate to in person visits in the study and accounts for approximately half of the API cases included in the study nationwide. SEARCH data indicates that the prevalence of Type 2 diabetes among API was 3 times higher compared to non-Hispanic whites. As a study center, Hawaii offers many advantages including a low rate of uninsured residents and low migration, and due to geographic isolation, diabetes care is received almost exclusively within the State.

National Institute of Health (NIH)
National Center for Chronic Disease Prev and Health Promo (NCCDPHP)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZDP1-FXR (DT))
Program Officer
Sims, Joyner
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Pacific Health Research Institute
United States
Zip Code
Kanakatti Shankar, Roopa; Dolan, Lawrence M; Isom, Scott et al. (2017) Serum cystatin C in youth with diabetes: The SEARCH for diabetes in youth study. Diabetes Res Clin Pract 130:258-265
Corathers, Sarah D; Kichler, Jessica C; Fino, Nora F et al. (2017) High health satisfaction among emerging adults with diabetes: Factors predicting resilience. Health Psychol 36:206-214
Yi-Frazier, Joyce P; Hilliard, Marisa E; Fino, Nora F et al. (2016) Whose quality of life is it anyway? Discrepancies between youth and parent health-related quality of life ratings in type 1 and type 2 diabetes. Qual Life Res 25:1113-21
Tomer, Yaron; Dolan, Lawrence M; Kahaly, George et al. (2015) Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes. J Autoimmun 60:32-9
Li, Chao; Beech, Bettina; Crume, Tessa et al. (2015) Longitudinal association between television watching and computer use and risk markers in diabetes in the SEARCH for Diabetes in Youth Study. Pediatr Diabetes 16:382-91
Saydah, Sharon H; Imperatore, Giuseppina; Henkin, Leora et al. (2015) Trends and characteristics of self-reported case presentation of diabetes diagnosis among youth from 2002 to 2010: findings from the SEARCH for diabetes in youth study. Diabetes Care 38:e84-5
Liese, Angela D; Crandell, Jamie L; Tooze, Janet A et al. (2015) Sugar-sweetened beverage intake and cardiovascular risk factor profile in youth with type 1 diabetes: application of measurement error methodology in the SEARCH Nutrition Ancillary Study. Br J Nutr 114:430-8
Liese, Angela D; Crandell, Jamie L; Tooze, Janet A et al. (2015) Relative validity and reliability of an FFQ in youth with type 1 diabetes. Public Health Nutr 18:428-37
Crume, T L; Crandell, J; Norris, J M et al. (2014) Timing of complementary food introduction and age at diagnosis of type 1 diabetes: the SEARCH nutrition ancillary study (SNAS). Eur J Clin Nutr 68:1258-60
Naughton, Michelle J; Yi-Frazier, Joyce P; Morgan, Timothy M et al. (2014) Longitudinal associations between sex, diabetes self-care, and health-related quality of life among youth with type 1 or type 2 diabetes mellitus. J Pediatr 164:1376-83.e1

Showing the most recent 10 out of 66 publications