Eye diseases leading to visual impairment and blindness are an important source of morbidity, decrease the quality of life for people of all ages, and place a substantial burden on health care resources. Eye care professionals, who diagnose vision disorders and practice sight-saving treatments, rely on findings from comparative effectiveness research to make well-informed health care decisions. Despite the critical need for better information, there are few established infrastructures for performing eyes and vision systematic reviews in the US only one, the Cochrane Collaboration's Eyes and Vision Group. US Satellite (CEVG(gUS) is subject specific, sustainable, provides education and facilitates collaboration by allowing anyone to contribute, as long as the research is high quality. CEVG@US. which has been producing reviews since 1997. ensures important eyes and vision systematic review topics are prioritized, performed, disseminated, and kept up-to-date; it educates and builds a workforce that performs high quality systematic reviews; and provides a forum for US researchers to play an instrumental role in developing methods for comparative effectiveness research. Building on CEVG's previous experiences and achievements, the over-arching objective of this proposal is to serve as a coordinating center for comparative effectiveness research, and specifically Cochrane systematic reviews, in eyes and vision in the US. This role is comparable to that of a coordinating center for a clinical trial or clinical research network. Specifically, the aims are to 1) educate and build a sustainable vision science workforce in comparative effectiveness research; 2) identify targeted areas where evidence is needed; 3) prepare and keep up-to-date systematic reviews addressing targeted questions; 4) conduct research on methods to identify evidence gaps; 5) build a study-based, publicly available vision trials register; 6) conduct methodological research in systematic reviews; 7) disseminate the results of our research. The proposed research is served by the long standing infrastructure of the Cochrane Collaboration, and is led by a highly trained research team.
By conducting and supporting comparative effectiveness research, training eyes and vision practitioners and researchers, disseminating health information, the outcome of the proposed work will have substantial impact on preventing or treating eye diseases and/or visual impairment, and improving the quality of life for people of all ages.
| Le, Jimmy T; Rouse, Benjamin; Gazzard, Gus (2018) Iridotomy to slow progression of visual field loss in angle-closure glaucoma. Cochrane Database Syst Rev 6:CD012270 |
| Michelessi, Manuele; Bicket, Amanda K; Lindsley, Kristina (2018) Cyclodestructive procedures for non-refractory glaucoma. Cochrane Database Syst Rev 4:CD009313 |
| Do, Diana V; Gichuhi, Stephen; Vedula, Satyanarayana S et al. (2018) Surgery for postvitrectomy cataract. Cochrane Database Syst Rev 1:CD006366 |
| Gupta, Amisha; Lam, Jessica; Custis, Peter et al. (2018) Implantable miniature telescope (IMT) for vision loss due to end-stage age-related macular degeneration. Cochrane Database Syst Rev 5:CD011140 |
| Saldanha, Ian J; Petris, Rebecca; Han, Genie et al. (2018) Research Questions and Outcomes Prioritized by Patients With Dry Eye. JAMA Ophthalmol 136:1170-1179 |
| Jin, Chongfei; Chen, Xinyi; Law, Andrew et al. (2017) Different-sized incisions for phacoemulsification in age-related cataract. Cochrane Database Syst Rev 9:CD010510 |
| Law, Andrew; Lindsley, Kristina; Rouse, Benjamin et al. (2017) Missed opportunity from randomised controlled trials of medical interventions for open-angle glaucoma. Br J Ophthalmol 101:1315-1317 |
| Jasper, Smitha; Vedula, Satyanarayana S; John, Sheeja S et al. (2017) Corticosteroids as adjuvant therapy for ocular toxoplasmosis. Cochrane Database Syst Rev 1:CD007417 |
| Saldanha, Ian J; Lindsley, Kristina; Do, Diana V et al. (2017) Comparison of Clinical Trial and Systematic Review Outcomes for the 4 Most Prevalent Eye Diseases. JAMA Ophthalmol 135:933-940 |
| Mayo-Wilson, Evan; Ng, Sueko Matsumura; Chuck, Roy S et al. (2017) The quality of systematic reviews about interventions for refractive error can be improved: a review of systematic reviews. BMC Ophthalmol 17:164 |
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