The Pharmacogenefics Research Network (PGRN) has matured to the point that there are now numerous network activities, such that an administrative support structure for the network is needed. Many of the PGRN Logistics Resource functions described herein have been historically handled by the PGRN Program Director (Dr. Rochelle Long), commercial meeting planners, or the PharmGKB. With the increased activities of the PGRN, it is unrealistic and an inefficient use of the Dr. Long's scientific expertise to have her and her office serve the network in so many administrative capacifies. Additionally, the PharmGKB has historically been funded under the PGRN, and one of its functions has been to provide the PGRN with a website. However, the PharmGKB will now be funded under a separate RFA and will no longer be part of the PGRN. As such, a PGRN website is needed. Finally, the PGRN holds twice annual scientific meetings, along with face to face Steering Committee meetings, and organization of these meetings could be more efficiently handled through a central PGRN administrafive site than through the current process of government bidding and contracting of meefing planners. Thus, the network is in crifical need of a network resource that would provide logistics infrastructure to the network and its activities.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-GGG-M)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Florida
United States
Zip Code
El Rouby, Nihal; McDonough, Caitrin W; Gong, Yan et al. (2018) Genome-wide association analysis of common genetic variants of resistant hypertension. Pharmacogenomics J :
Wenger, Nanette K; Arnold, Anita; Bairey Merz, C Noel et al. (2018) Hypertension Across a Woman's Life Cycle. J Am Coll Cardiol 71:1797-1813
McDonough, Caitrin W; Magvanjav, Oyunbileg; Sá, Ana C C et al. (2018) Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses). Circ Genom Precis Med 11:e001854
Empey, Philip E; Stevenson, James M; Tuteja, Sony et al. (2018) Multisite Investigation of Strategies for the Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy. Clin Pharmacol Ther 104:664-674
Chang, S-W; McDonough, C W; Gong, Y et al. (2018) Genome-wide association study identifies pharmacogenomic loci linked with specific antihypertensive drug treatment and new-onset diabetes. Pharmacogenomics J 18:106-112
Wang, Danxin; Hartmann, Katherine; Seweryn, Michal et al. (2018) Interactions Between Regulatory Variants in CYP7A1 (Cholesterol 7?-Hydroxylase) Promoter and Enhancer Regions Regulate CYP7A1 Expression. Circ Genom Precis Med 11:e002082
Sá, Ana Caroline C; Webb, Amy; Gong, Yan et al. (2018) Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies. BMC Med Genomics 11:55
Weitzel, Kristin W; Smith, D Max; Elsey, Amanda R et al. (2018) Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned. Clin Transl Sci 11:175-181
Cavallari, Larisa H; Lee, Craig R; Beitelshees, Amber L et al. (2018) Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention. JACC Cardiovasc Interv 11:181-191
Smith, D Max; Weitzel, Kristin W; Cavallari, Larisa H et al. (2018) Clinical application of pharmacogenetics in pain management. Per Med 15:117-126

Showing the most recent 10 out of 178 publications