Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01GM094612-03
Application #
8377396
Study Section
Special Emphasis Panel (ZGM1-CBB-0)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
3
Fiscal Year
2012
Total Cost
$120,923
Indirect Cost
$39,624
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Gustavsson, Martin; Zheng, Yi; Handel, Tracy M (2016) Production of Chemokine/Chemokine Receptor Complexes for Structural Biophysical Studies. Methods Enzymol 570:233-60
Leach, Katie; Gregory, Karen J; Kufareva, Irina et al. (2016) Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor. Cell Res 26:574-92
Zheng, Yi; Qin, Ling; Zacarías, Natalia V Ortiz et al. (2016) Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. Nature 540:458-461
Ngo, Tony; Kufareva, Irina; Coleman, James Lj et al. (2016) Identifying ligands at orphan GPCRs: current status using structure-based approaches. Br J Pharmacol 173:2934-51
Kufareva, Irina; Salanga, Catherina L; Handel, Tracy M (2015) Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies. Immunol Cell Biol 93:372-83
Husby, Jarmila; Bottegoni, Giovanni; Kufareva, Irina et al. (2015) Structure-based predictions of activity cliffs. J Chem Inf Model 55:1062-76
Kufareva, Irina; Handel, Tracy M; Abagyan, Ruben (2015) Experiment-Guided Molecular Modeling of Protein-Protein Complexes Involving GPCRs. Methods Mol Biol 1335:295-311
Geidl, Stanislav; Svobodová Va?eková, Radka; Bendová, Veronika et al. (2015) How Does the Methodology of 3D Structure Preparation Influence the Quality of pKa Prediction? J Chem Inf Model 55:1088-97
Lenoir, Marc; Kufareva, Irina; Abagyan, Ruben et al. (2015) Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily. Membranes (Basel) 5:646-63
Qin, Ling; Kufareva, Irina; Holden, Lauren G et al. (2015) Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science 347:1117-22

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