Public Health Relevance

This is a critical area of Human Health. Cell adhesion complexes are important in all aspects of normal cell and tissue function, and are commonly defective in genetic diseases and cancers. Results will provide new understanding of how defects disrupt normal function and contribute to disease, and potentially identify new therapeutic targets.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01GM094663-03
Application #
8382499
Study Section
Special Emphasis Panel (ZGM1-CBB-0)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
3
Fiscal Year
2012
Total Cost
$611,545
Indirect Cost
$107,030
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Shao, Xiangqiang; Kang, Hyunook; Loveless, Timothy et al. (2017) Cell-cell adhesion in metazoans relies on evolutionarily conserved features of the ?-cateninĀ·?-catenin-binding interface. J Biol Chem 292:16477-16490
Kang, Hyunook; Bang, Injin; Jin, Kyeong Sik et al. (2017) Structural and functional characterization of Caenorhabditis elegans ?-catenin reveals constitutive binding to ?-catenin and F-actin. J Biol Chem 292:7077-7086
Clarke, Donald Nathaniel; Miller, Phillip W; Lowe, Christopher J et al. (2016) Characterization of the Cadherin-Catenin Complex of the Sea Anemone Nematostella vectensis and Implications for the Evolution of Metazoan Cell-Cell Adhesion. Mol Biol Evol 33:2016-29
Dassama, Laura M K; Kenney, Grace E; Ro, Soo Y et al. (2016) Methanobactin transport machinery. Proc Natl Acad Sci U S A 113:13027-13032
Choi, Hee-Jung; Weis, William I (2016) Purification and Structural Analysis of Desmoplakin. Methods Enzymol 569:197-213
Nelson, W James; Weis, William I (2016) 25 Years of Tension over Actin Binding to the Cadherin Cell Adhesion Complex: The Devil is in the Details. Trends Cell Biol 26:471-473
Bianchini, Julie M; Kitt, Khameeka N; Gloerich, Martijn et al. (2015) Reevaluating ?E-catenin monomer and homodimer functions by characterizing E-cadherin/?E-catenin chimeras. J Cell Biol 210:1065-74
Choi, Hee-Jung; Loveless, Timothy; Lynch, Allison M et al. (2015) A conserved phosphorylation switch controls the interaction between cadherin and ?-catenin in vitro and in vivo. Dev Cell 33:82-93
Karginov, Andrei V; Tsygankov, Denis; Berginski, Matthew et al. (2014) Dissecting motility signaling through activation of specific Src-effector complexes. Nat Chem Biol 10:286-90
Slattery, Scott D; Hahn, Klaus M (2014) A High-Content Assay for Biosensor Validation and for Examining Stimuli that Affect Biosensor Activity. Curr Protoc Cell Biol 65:14.15.1-31

Showing the most recent 10 out of 26 publications