The Community Child Health Network (CCHN) Phase II research proposes to: (1) advance understanding of the combined biomedical, social, behavioral, and environmental influences on the course of prenatal development, pregnancy outcome, and early child development, particularly in physical growth, respiratory function, and language development. CCHN proposes a 5-site, longitudinal study of 2 integrated cohorts: a Birth Cohort Study of 5250 families (1050 per site)) followed by a Subsequent Birth Study (38 percent of mothers expected to have a subsequent livebirth). These studies focus on the role of stress and allostatic load, as moderated by resilience and supports, on pregnancy outcome, fetal programming, and child development outcomes of prematurity/intrauterine growth restriction, overweight, asthma, and language and cognitive development;and (2) to develop and document active community participation in all phases of the study through the community based participatory research (CBPR) in the community-academic partnerships (CAPs). The findings are intended to advance theory about the etiology and impact of health disparities related to pregnancy and early childhood outcomes, as well as inform the design of future preventive interventions. Innovative features include: 1) focus on the inter- and pre-conception period;2) combining biomedical and psychosocial indicators and outcomes within an integrated conceptual framework;3) multidisciplinary measures of resilience and supports as well as risks;4) including fathers as integral to both pregnancy and child health outcomes;and 5) a participatory research partnership of the community and university at local sites and the national network. CCHN-LA is comprised of academic partners from UCLA and its affiliates (Cedars-Sinai, Good Samaritan, Harbor-UCLA, &King-Drew Medical Centers) and community partners in South and Central Los Angeles organized by Healthy African American Families (HAAF). The strengths of CCHN-LA include expertise and extensive experience in CBPR, stress and allostatic load, resilience and support, preterm birth, racial-ethnic disparities in perinatal outcomes, and research methodologies including study design, measurements and data analyses. CCHN-LA will enroll and follow 1050 families (15 percent African American, 65 percent Latino, 20 percent non-Hispanic White;also 80 percent poor and near- poor) residing in the Harbor Freeway Corridor and adjacent areas of Los Angeles County.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HD044245-08
Application #
8144257
Study Section
Special Emphasis Panel (ZHD1-DSR-M (08))
Program Officer
Willinger, Marian
Project Start
2003-09-19
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
8
Fiscal Year
2011
Total Cost
$515,128
Indirect Cost
Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048
O'Campo, Patricia; Schetter, Christine Dunkel; Guardino, Christine M et al. (2016) Explaining racial and ethnic inequalities in postpartum allostatic load: Results from a multisite study of low to middle income woment. SSM Popul Health 2:850-858
Guardino, Christine M; Schetter, Christine Dunkel; Saxbe, Darby E et al. (2016) Diurnal salivary cortisol patterns prior to pregnancy predict infant birth weight. Health Psychol 35:625-33
Tanner Stapleton, Lynlee R; Dunkel Schetter, Christine; Dooley, Larissa N et al. (2016) The Community Child Health Network Life Stress Interview: a brief chronic stress measure for community health research. Anxiety Stress Coping 29:352-66
Schetter, Christine Dunkel; Saxbe, Darby; Cheadle, Alyssa et al. (2016) Postpartum Depressive Symptoms Following Consecutive Pregnancies: Stability, Change, and Mechanisms. Clin Psychol Sci 4:909-918
McKinney, Chelsea O; Hahn-Holbrook, Jennifer; Chase-Lansdale, P Lindsay et al. (2016) Racial and Ethnic Differences in Breastfeeding. Pediatrics 138:
Simon, Clarissa D; Adam, Emma K; McKinney, Chelsea O et al. (2016) Breastfeeding, Bed-Sharing, and Maternal Cortisol. Clin Pediatr (Phila) 55:470-8
Straub, Heather; Simon, Clarissa; Plunkett, Beth A et al. (2016) Evidence for a Complex Relationship Among Weight Retention, Cortisol and Breastfeeding in Postpartum Women. Matern Child Health J 20:1375-83
Ramey, Sharon Landesman; Schafer, Peter; DeClerque, Julia L et al. (2015) The Preconception Stress and Resiliency Pathways Model: a multi-level framework on maternal, paternal, and child health disparities derived by community-based participatory research. Matern Child Health J 19:707-19
Saxbe, Darby E; Adam, Emma K; Schetter, Christine Dunkel et al. (2015) Cortisol covariation within parents of young children: Moderation by relationship aggression. Psychoneuroendocrinology 62:121-8
Endres, Loraine K; Straub, Heather; McKinney, Chelsea et al. (2015) Postpartum weight retention risk factors and relationship to obesity at 1 year. Obstet Gynecol 125:144-52

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