Prenatal alcohol exposure has long been linked to deficits in neurodevelopmental, growth, and systemic functions in infants under the rubric of fetal alcohol spectrum disorders (FASD), with fetal alcohol syndrome at the most severe end of the spectrum. Yet, increasing epidemiologic, physiologic, and pathologic data suggest potential relationships between prenatal alcohol exposure and mortality, including the sudden infant death syndrome (SIDS) and stillbirth. These mortality data in conjunction with the morbidity data underscore the enormous personal and societal burden of maternal drinking during pregnancy, and the urgent need for more effective intervention strategies. The mission of the PASS Network is to perform community-linked studies to determine the role of prenatal alcohol exposure in the risk for SIDS and adverse pregnancy outcomes, especially stillbirth and FASD. This application proposes the completion of enrollment and follow- up of study participants and the performance of data analysis in Phase II of the PASS Network by the Northern Plains Comprehensive Clinical Site (NPCCS). To carry out the mission of the PASS Network, a highly skilled interdisciplinary team has been assembled at the NPCCS that has been working successfully together throughout Phase II. A community-based infrastructure serves as the foundation for the NPCCS that incorporates hospitals, prenatal clinics, pediatric clinics, medical examiner systems, pathology departments, social service agencies, tribal colleges and community review boards. In addition, the NPCCS is responsible for the design and analysis of the FASD case determinations through analysis of facial dysmorphology. The NPCCS conducts all of these activities within a management structure designed to optimize active recruitment and collection of high quality data with care and compassion for the participants and communities it serves.

Public Health Relevance

The potential impact of the Northern Plains CCS is to develop strategies to improve the care of mothers and their children in populations in which prenatal alcohol exposure is a significant public health problem, as delineated in the common section above.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01HD045935-09
Application #
8203820
Study Section
Special Emphasis Panel (ZAA1-GG (02))
Program Officer
Willinger, Marian
Project Start
2003-09-26
Project End
2016-07-31
Budget Start
2011-09-26
Budget End
2012-07-31
Support Year
9
Fiscal Year
2011
Total Cost
$1,806,947
Indirect Cost
Name
Sanford Research/Usd
Department
Type
DUNS #
050113252
City
Sioux Falls
State
SD
Country
United States
Zip Code
57104
Dukes, Kimberly; Tripp, Tara; Petersen, Julie et al. (2017) A modified Timeline Followback assessment to capture alcohol exposure in pregnant women: Application in the Safe Passage Study. Alcohol 62:17-27
Odendaal, Hein; Groenewald, Coen; Hankins, Gary D V et al. (2017) Transabdominal recordings of fetal heart rate in extremely small fetuses. J Matern Fetal Neonatal Med :1-4
Geldenhuys, Elaine; Coldrey, Jean; Wright, Colleen et al. (2017) Fetal foot length at delivery as a tool for determining gestation length in non-macerated stillbirths. Int J Gynaecol Obstet 138:107-112
Dukes, Kimberly; Tripp, Tara; Willinger, Marian et al. (2017) Drinking and smoking patterns during pregnancy: Development of group-based trajectories in the Safe Passage Study. Alcohol 62:49-60
Hartman, Terryl J; Elliott, Amy J; Angal, Jyoti et al. (2017) Relative validation of a short questionnaire to assess the dietary habits of pregnant American Indian women. Food Sci Nutr 5:625-632
Myers, Michael M; Elliott, Amy J; Odendaal, Hein J et al. (2017) Cardiorespiratory physiology in the safe passage study: protocol, methods and normative values in unexposed infants. Acta Paediatr 106:1260-1272
Haynes, Robin L; Folkerth, Rebecca D; Paterson, David S et al. (2016) Serotonin Receptors in the Medulla Oblongata of the Human Fetus and Infant: The Analytic Approach of the International Safe Passage Study. J Neuropathol Exp Neurol :
Angal, Jyoti; Petersen, Julie M; Tobacco, Deborah et al. (2016) Ethics Review for a Multi-Site Project Involving Tribal Nations in the Northern Plains. J Empir Res Hum Res Ethics 11:91-6
Dempers, Johan J; Coldrey, Jean; Burger, Elsie H et al. (2016) The Institution of a Standardized Investigation Protocol for Sudden Infant Death in the Eastern Metropole, Cape Town, South Africa,. J Forensic Sci 61:1508-1514
Brito, Natalie H; Fifer, William P; Myers, Michael M et al. (2016) Associations among family socioeconomic status, EEG power at birth, and cognitive skills during infancy. Dev Cogn Neurosci 19:144-51

Showing the most recent 10 out of 27 publications