There is an epidemic of cardiovascular disease (CVD) among American Indians. The Strong Heart Study (SHS) has been examining CVD and its risk factors by conducting a longitudinal cohort study and a family genetic study among 13 communities in 3 geographic areas (Arizona, the Dakotas, and Oklahoma). This application proposes to extend the SHS to pursue the following aims: 1) Expand the genetic studies that will emphasize the genome scan approach, but also include investigation of carefully selected candidate genes. The completed genome scan of 3776 members from 94 extended families will be used to identify quantitative trait loci and narrow the regions of interest by fine mapping. We also will examine a selected number of candidate genes that are difficult to exclude on the basis of linkage studies, but are of potential importance to vascular disease. 2) Continue the mortality and morbidity surveillance of the original cohort (approximately 2859 male and female survivors, ages 60 - 89 years) and to initiate annual mortality surveillance and limited morbidity follow-up of the non-cohort family members. 3) Re-examine the family members so that changes in risk factors can be analyzed and genetic effects on changes estimated. Advantages of the SHS include: 1) It provides health data on an underserved ethnic group. 2) It is the largest, longest longitudinal study in the US of CVD and its risk factors in individuals with diabetes. 3) Data from cardiac, carotid, and popliteal ultrasound measures will substantially improve understanding of mechanisms of vascular disease in diabetes and the genetics of CVD. 4) This population includes a group, in which the epidemic of obesity and diabetes has impacted people at very young ages, permitting analysis of genetic and environmental effects on these conditions with limited confounding by age effects. SHS will lead to valuable therapeutic and prevention strategies for this and other populations in the US and the world, where the epidemics of obesity, diabetes, and CVD are progressing rapidly. The relevance of this research to public health: The SHS studies diseases of the heart and blood vessels in American Indian Communities, in order to try to explain the rapid increases that have been recently observed. The study is attempting to learn about predictors of disease, and to see to what extent it runs in families. SHS is valuable because it provides information on how diabetes leads to diseases of the heart and blood vessels that will be useful in many populations who now have high rates of diabetes.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project--Cooperative Agreements (U01)
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Special Emphasis Panel (ZHL1-CSR-L (F1))
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Fabsitz, Richard
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University of Oklahoma Health Sciences Center
Schools of Public Health
Oklahoma City
United States
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Ferrara, L A; Capaldo, B; Mancusi, C et al. (2014) Cardiometabolic risk in overweight subjects with or without relative fat-free mass deficiency: the Strong Heart Study. Nutr Metab Cardiovasc Dis 24:271-6
Chen, Shufeng; Yeh, Fawn; Lin, Jue et al. (2014) Short leukocyte telomere length is associated with obesity in American Indians: the Strong Heart Family study. Aging (Albany NY) 6:380-9
Zhao, Jinying; Roman, Mary J; Devereux, Richard B et al. (2014) Leukotriene haplotype × diet interaction on carotid artery hypertrophy and atherosclerosis in American Indians: the Strong Heart Family Study. Atherosclerosis 233:165-71
Chen, Shufeng; Lin, Jue; Matsuguchi, Tet et al. (2014) Short leukocyte telomere length predicts incidence and progression of carotid atherosclerosis in American Indians: the Strong Heart Family Study. Aging (Albany NY) 6:414-27
Yeh, Fawn; Dixon, Anne E; Best, Lyle G et al. (2014) Lung function and heart disease in American Indian adults with high frequency of metabolic abnormalities (from the Strong Heart Study). Am J Cardiol 114:312-9
Zhu, Yun; Yang, Jingyun; Yeh, Fawn et al. (2014) Joint association of nicotinic acetylcholine receptor variants with abdominal obesity in American Indians: the Strong Heart Family Study. PLoS One 9:e102220
Gribble, Matthew O; Tang, Wan-Yee; Shang, Yan et al. (2014) Differential methylation of the arsenic (III) methyltransferase promoter according to arsenic exposure. Arch Toxicol 88:275-82
Franceschini, Nora; Haack, Karin; Almasy, Laura et al. (2014) Generalization of associations of kidney-related genetic loci to American Indians. Clin J Am Soc Nephrol 9:150-8
Fretts, Amanda M; Howard, Barbara V; McKnight, Barbara et al. (2014) Life's Simple 7 and incidence of diabetes among American Indians: the Strong Heart Family Study. Diabetes Care 37:2240-5
García-Esquinas, Esther; Pollan, Marina; Tellez-Plaza, Maria et al. (2014) Cadmium exposure and cancer mortality in a prospective cohort: the strong heart study. Environ Health Perspect 122:363-70

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