This application is the response of the University of Washington and Emergency Medical Services (EMS) of Seattle and King County, WA to the RFA HL-04-001 entitled """"""""Clinical Research Consortium to Improve Resuscitation Outcomes."""""""" The EMS of Seattle and King County have a programmatic focus on cardiac arrest and life-threatening trauma and continue to make important contributions to each link in the American Heart Association's """"""""chain of survival,"""""""" as well as important advances in trauma management. An experienced group of internationally renown investigators, along with the infrastructure and resources provided by the University with broad community support, are committed to advancing resuscitation science through the training of young investigators in the field of prehospital emergency care and the conduct of clinical trials. This application sets forth 2 research proposals pertaining to management of out-of-hospital cardiac arrest, and life-threatening trauma that exemplify the insights and expertise of the assembled team of researchers and the quality of the local prehospital care system. The cardiac arrest proposal is a prospective, randomized, double-blind comparison of amiodarone, lidocaine and placebo in out-of-hospital ventricular fibrillation that will assess the impact of such treatment on neurologically functional survival. The trauma protocol is a similarly designed comparison of 7.5% hypertonic saline in dextran, 3% saline, and conventional fluid resuscitation on mortality and neurologic function after blunt traumatic injury associated with hypovolemic shock. Each proposal will enroll between 400-500 patients over a two year period, and will have enhanced statistical power to establish their important endpoints through participation of a Consortium of clinical research centers. Finally, a Clinical Research Skills Development Core is proposed, founded on the rich research and teaching environment of the University and prehospital care system to foster and direct the training of young investigators from a variety of disciplines in resuscitation research.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL077867-05
Application #
7468351
Study Section
Special Emphasis Panel (ZHL1-CSR-G (M1))
Program Officer
Sopko, George
Project Start
2004-09-01
Project End
2010-02-28
Budget Start
2008-07-01
Budget End
2010-02-28
Support Year
5
Fiscal Year
2008
Total Cost
$387,111
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Pollack, Ross A; Brown, Siobhan P; Rea, Thomas et al. (2018) Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests. Circulation 137:2104-2113
Blewer, Audrey L; McGovern, Shaun K; Schmicker, Robert H et al. (2018) Gender Disparities Among Adult Recipients of Bystander Cardiopulmonary Resuscitation in the Public. Circ Cardiovasc Qual Outcomes 11:e004710
Hansen, Matthew; Schmicker, Robert H; Newgard, Craig D et al. (2018) Time to Epinephrine Administration and Survival From Nonshockable Out-of-Hospital Cardiac Arrest Among Children and Adults. Circulation 137:2032-2040
Brooks, Steven C; Schmicker, Robert H; Cheskes, Sheldon et al. (2017) Variability in the initiation of resuscitation attempts by emergency medical services personnel during out-of-hospital cardiac arrest. Resuscitation 117:102-108
Salcido, David D; Schmicker, Robert H; Buick, Jason E et al. (2017) Compression-to-ventilation ratio and incidence of rearrest-A secondary analysis of the ROC CCC trial. Resuscitation 115:68-74
Drennan, Ian R; Case, Erin; Verbeek, P Richard et al. (2017) A comparison of the universal TOR Guideline to the absence of prehospital ROSC and duration of resuscitation in predicting futility from out-of-hospital cardiac arrest. Resuscitation 111:96-102
Kudenchuk, Peter J; Leroux, Brian G; Daya, Mohamud et al. (2017) Antiarrhythmic Drugs for Nonshockable-Turned-Shockable Out-of-Hospital Cardiac Arrest: The ALPS Study (Amiodarone, Lidocaine, or Placebo). Circulation 136:2119-2131
Wang, Henry E; Prince, David K; Drennan, Ian R et al. (2017) Post-resuscitation arterial oxygen and carbon dioxide and outcomes after out-of-hospital cardiac arrest. Resuscitation 120:113-118
Morrison, Laurie J; Schmicker, Robert H; Weisfeldt, Myron L et al. (2016) Effect of gender on outcome of out of hospital cardiac arrest in the Resuscitation Outcomes Consortium. Resuscitation 100:76-81
Rizoli, Sandro; Petersen, Ashley; Bulger, Eileen et al. (2016) Early prediction of outcome after severe traumatic brain injury: a simple and practical model. BMC Emerg Med 16:32

Showing the most recent 10 out of 94 publications