The overall goals of this International Cooperative Biodiversity group are to achieve the threefold mission of biodiversity conservation, economic development, and drug discovery in Madagascar. The proposed research integrates the work of seven different associate programs into a coherent whole to achieve these goals. The drug discovery mission will have a threefold approach to collecting biomaterials in Madagascar. Plants will be collected by botanists from Missouri Botanical Garden (MBG) Conservation International (CI) and the Centre National d'Application et des Recherches Pharmaceutiques (CNARP). Marine organisms will be collected by teams from Centre National de Recherches sur l'Environnement (CNRE) and Centre National de Recherches Oceanographiques (CNRO). Microbial strain isolation from soil samples will be carried out by scientists from CNARP after receiving training at DowAgroSciences (DAS). The plants will be extracted by workers at the CNARP, and the marine organisms will be extracted by workers at CNRE and CNRO. Subsequent bioassays, fractionation studies, and chemistry will be carried out by CNARP, Eisai Research Institute (ERI), DAS and Virginia Polytechnic Institute and State University (VPISU) in the interest areas of cancer, immunology, malaria, neurological disease, tuberculosis, and agrochemistry, and royalties will be paid to Madagascar on sales of any pharmaceuticals or agrochemicals that are developed from this work. Pure microbial strains will be cultured by one or both of the industrial partners and active compounds of interest will then be isolated from these culture broths. In addition to the drug discovery work outlined above, the Group will also carry out economic development and biodiversity conservation initiatives in Madagascar. In Madagascar the work will include the completion of biodiversity surveys of well-defined forest preserves, as well as training in botanical methods at MBG, training in microbial techniques at DAS, and training in natural product isolation at VPISU. The work will also involve local stakeholders in decisions about the use of upfront funds contributed by DAS and ERI.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01TW000313-20S1
Application #
8702469
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (52))
Program Officer
Katz, Flora N
Project Start
1998-09-30
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2014-05-31
Support Year
20
Fiscal Year
2013
Total Cost
$186,500
Indirect Cost
$39,283
Name
Virginia Polytechnic Institute and State University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
003137015
City
Blacksburg
State
VA
Country
United States
Zip Code
24061
Su, Qingxi; Brodie, Peggy J; Liu, Yixi et al. (2016) Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest. Nat Prod Bioprospect 6:31-9
Rasamison, Vincent E; Brodie, Peggy J; Merino, Emilio F et al. (2016) Furoquinoline Alkaloids and Methoxyflavones from the Stem Bark of Melicope madagascariensis (Baker) T.G. Hartley. Nat Prod Bioprospect 6:261-265
Bao, Xingfeng; Zheng, Wanjun; Hata Sugi, Naoko et al. (2015) Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking. Cancer Biol Ther 16:589-601
Liu, Yixi; Wiedle Jr, C Houston; Brodie, Peggy J et al. (2015) Antiproliferative Diterpenes from a Malleastrum sp. from the Madagascar dry forest. Nat Prod Commun 10:1509-12
Presley, Christopher C; Rakotondraibe, L Harinantenaina; Brodie, Peggy J et al. (2015) A Synthetic Butenolide Diterpene is now a Natural Product Isolated from Metaporana sericosepala, a Plant from the Madagascar Dry Forest. Nat Prod Commun 10:1505-7
Su, Qingxi; Krai, Priscilla; Goetz, Michael et al. (2015) Antiplasmodial Isoflavanes and Pterocarpans from Apoplanesia paniculata. Planta Med 81:1128-32
Liu, Yixi; Rakotondraibe, L Harinantenaina; Brodie, Peggy J et al. (2015) Antimalarial 5,6-Dihydro-α-pyrones from Cryptocarya rigidifolia: Related Bicyclic Tetrahydro-α-Pyrones Are Artifacts1. J Nat Prod 78:1330-8
Liu, Yixi; Young, Kelly; Rakotondraibe, L Harinantenaina et al. (2015) Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest. J Nat Prod 78:1543-7
Liu, Yixi; Cheng, Emily; Rakotondraibe, L Harinantenaina et al. (2015) Antiproliferative Compounds from Ocotea macrocarpa from the Madagascar Dry Forest(1). Tetrahedron Lett 56:3630-3632
Harinantenaina Rakotondraibe, L; Rasolomampianina, Rado; Park, Hyun-Young et al. (2015) Antiproliferative and antiplasmodial compounds from selected Streptomyces species. Bioorg Med Chem Lett 25:5646-9

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