1. An Overview of Subject Selection and Characteristics The original COGA Guidelines for selection of probands, Identiflcation of appropriate relatives, and selection of controls and their families are outiined above. The proposed work will recruit no new families and will only draw upon members of the existing pedigrees. Appropriate members of COGA probands and comparison families will be invited to continue to participate In the prospective panel study, along with children who """"""""age up"""""""" to the 12-year minimum age required for participation. Alcoholic probands had been originally ascertained from consecutive admissions to public and private inpatient and outpatient treatment facilities at each ofthe COGA participating sites. This Included individuals who fulfilled the COGA criteria for alcohol dependence, and who had multiple alcohol-dependent relatives living within 50 to 150 miles ofthe COGA Centers. Comparison families were selected using different methods across the subject collection sites, with approaches including random mailings to individuals affiliated with the respective university, people who are attending dental and medical clinic patients, and a random assessment through public records. Potential probands were excluded from the study if they had a mortal illness, were current IV drug users, reported an extensive history of IV drug use (31+ times), or were known to be infected with the HIV virus. These exclusion criteria are not applied to family members. In general, for all subjects medical or psychiatric conditions were the only general grounds for exclusion if it seemed probable that they might compromise a subject's ability to provide informed consent (e.g., advanced Alzheimer's disease) or hinder one's participation in the blood sampling or electrophysiological portions ofthe study (e.g., liver disease, neurological disease, head injuries, etc.). For the current ongoing study of adolescents and young adults, individuals younger than the age of majority (18 years) are assessed (including direct interviews, neurophysiological and electrophysiological testing, and blood samples) only following written consent is obtained from the parents and assent of the subject. The study of adolescents and young adults is essential to facilitate genetic analyses of characteristics related to the onset of alcohol and substance use and associated problems. These findings will facilitate our understanding of the potential importance of specific genetic markers and enhance our understanding of eariy drinking parameters.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10AA008401-24
Application #
8381784
Study Section
Special Emphasis Panel (ZAA1-CC)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
24
Fiscal Year
2012
Total Cost
$507,924
Indirect Cost
Name
Suny Downstate Medical Center
Department
Type
DUNS #
040796328
City
Brooklyn
State
NY
Country
United States
Zip Code
11203
Hartz, Sarah M; Horton, Amy C; Oehlert, Mary et al. (2017) Association Between Substance Use Disorder and Polygenic Liability to Schizophrenia. Biol Psychiatry 82:709-715
Chorlian, David B; Rangaswamy, Madhavi; Manz, Niklas et al. (2017) Genetic correlates of the development of theta event related oscillations in adolescents and young adults. Int J Psychophysiol 115:24-39
Polimanti, Renato; Zhang, Huiping; Smith, Andrew H et al. (2017) Genome-wide association study of body mass index in subjects with alcohol dependence. Addict Biol 22:535-549
Jensen, K P; Smith, A H; Herman, A I et al. (2017) A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke. Mol Psychiatry 22:242-249
Grant, Julia D; Agrawal, Arpana; Werner, Kimberly B et al. (2017) Phenotypic and familial associations between childhood maltreatment and cannabis initiation and problems in young adult European-American and African-American women. Drug Alcohol Depend 179:146-152
Chartier, Karen G; Hesselbrock, Michie N; Hesselbrock, Victor M (2017) Introduction: Special issue on genetic research of alcohol use disorder in diverse racial/ethnic populations. Am J Addict 26:422-423
Mathies, Laura D; Aliev, Fazil; COGA Investigators et al. (2017) Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations. Alcohol Clin Exp Res 41:2033-2040
Bucholz, Kathleen K; McCutcheon, Vivia V; Agrawal, Arpana et al. (2017) Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study. Alcohol Clin Exp Res 41:359-368
Wang, Jian; Talluri, Rajesh; Shete, Sanjay (2017) Selection of X-chromosome Inactivation Model. Cancer Inform 16:1176935117747272
Agrawal, Arpana; Tillman, Rebecca; Grucza, Richard A et al. (2017) Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism. J Affect Disord 213:96-104

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